Detalhe da pesquisa
1.
Endogenous Plasma Kynurenic Acid in Human: A Newly Discovered Biomarker for Drug-Drug Interactions Involving Organic Anion Transporter 1 and 3 Inhibition.
Drug Metab Dispos
; 49(12): 1063-1069, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34599018
2.
Prediction of Transporter-Mediated Rosuvastatin Hepatic Uptake Clearance and Drug Interaction in Humans Using Proteomics-Informed REF Approach.
Drug Metab Dispos
; 49(2): 159-168, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33051248
3.
Mercapturate pathway metabolites of sotorasib, a covalent inhibitor of KRASG12C, are associated with renal toxicity in the Sprague Dawley rat.
Toxicol Appl Pharmacol
; 423: 115578, 2021 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34004237
4.
Advances in the study of drug metabolism - symposium report of the 12th Meeting of the International Society for the Study of Xenobiotics (ISSX).
Drug Metab Rev
; 52(3): 395-407, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32456484
5.
Comprehensive Evaluation of the Utility of 20 Endogenous Molecules as Biomarkers of OATP1B Inhibition Compared with Rosuvastatin and Coproporphyrin I.
J Pharmacol Exp Ther
; 368(1): 125-135, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30314992
6.
Evidence for the Validity of Pyridoxic Acid (PDA) as a Plasma-Based Endogenous Probe for OAT1 and OAT3 Function in Healthy Subjects.
J Pharmacol Exp Ther
; 368(1): 136-145, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30361237
7.
A Comparison of Total and Plasma Membrane Abundance of Transporters in Suspended, Plated, Sandwich-Cultured Human Hepatocytes Versus Human Liver Tissue Using Quantitative Targeted Proteomics and Cell Surface Biotinylation.
Drug Metab Dispos
; 47(4): 350-357, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30622164
8.
Further Studies to Support the Use of Coproporphyrin I and III as Novel Clinical Biomarkers for Evaluating the Potential for Organic Anion Transporting Polypeptide 1B1 and OATP1B3 Inhibition.
Drug Metab Dispos
; 46(8): 1075-1082, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29777022
9.
Discovery and Validation of Pyridoxic Acid and Homovanillic Acid as Novel Endogenous Plasma Biomarkers of Organic Anion Transporter (OAT) 1 and OAT3 in Cynomolgus Monkeys.
Drug Metab Dispos
; 46(2): 178-188, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29162614
10.
Transporter Expression in Noncancerous and Cancerous Liver Tissue from Donors with Hepatocellular Carcinoma and Chronic Hepatitis C Infection Quantified by LC-MS/MS Proteomics.
Drug Metab Dispos
; 46(2): 189-196, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29138286
11.
A Decade in the MIST: Learnings from Investigations of Drug Metabolites in Drug Development under the "Metabolites in Safety Testing" Regulatory Guidance.
Drug Metab Dispos
; 46(6): 865-878, 2018 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-29487142
12.
Bile Salt Homeostasis in Normal and Bsep Gene Knockout Rats with Single and Repeated Doses of Troglitazone.
J Pharmacol Exp Ther
; 362(3): 385-394, 2017 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28645914
13.
Comparative Evaluation of Plasma Bile Acids, Dehydroepiandrosterone Sulfate, Hexadecanedioate, and Tetradecanedioate with Coproporphyrins I and III as Markers of OATP Inhibition in Healthy Subjects.
Drug Metab Dispos
; 45(8): 908-919, 2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28576766
14.
Coproporphyrins I and III as Functional Markers of OATP1B Activity: In Vitro and In Vivo Evaluation in Preclinical Species.
J Pharmacol Exp Ther
; 357(2): 382-93, 2016 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-26907622
15.
Application of Static Models to Predict Midazolam Clinical Interactions in the Presence of Single or Multiple Hepatitis C Virus Drugs.
Drug Metab Dispos
; 44(8): 1372-80, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27226352
16.
Biotransformation of Daclatasvir In Vitro and in Nonclinical Species: Formation of the Main Metabolite by Pyrrolidine δ-Oxidation and Rearrangement.
Drug Metab Dispos
; 44(6): 809-20, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27029743
17.
Label-Free Bottom-Up Proteomic Workflow for Simultaneously Assessing the Target Specificity of Covalent Drug Candidates and Their Off-Target Reactivity to Selected Proteins.
Chem Res Toxicol
; 29(1): 109-16, 2016 Jan 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-26675335
18.
Drug-Protein Adducts: Chemistry, Mechanisms of Toxicity, and Methods of Characterization.
Chem Res Toxicol
; 29(12): 2040-2057, 2016 12 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-27989144
19.
Disruption of BSEP Function in HepaRG Cells Alters Bile Acid Disposition and Is a Susceptive Factor to Drug-Induced Cholestatic Injury.
Mol Pharm
; 13(4): 1206-16, 2016 Apr 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-26910619
20.
Characterization of ADME properties of [(14)C]asunaprevir (BMS-650032) in humans.
Xenobiotica
; 46(1): 52-64, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26153443