Detalhe da pesquisa
1.
Modulating the affinity and signaling bias of cannabinoid receptor 1 antagonists.
Bioorg Chem
; 130: 106236, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36371817
2.
Median nerve stimulation induces analgesia via orexin-initiated endocannabinoid disinhibition in the periaqueductal gray.
Proc Natl Acad Sci U S A
; 115(45): E10720-E10729, 2018 11 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30348772
3.
DUSP6 mediates T cell receptor-engaged glycolysis and restrains TFH cell differentiation.
Proc Natl Acad Sci U S A
; 115(34): E8027-E8036, 2018 08 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-30087184
4.
Fluorine-18 isotope labeling for positron emission tomography imaging. Direct evidence for DBPR211 as a peripherally restricted CB1 inverse agonist.
Bioorg Med Chem
; 27(1): 216-223, 2019 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30528163
5.
4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy.
Bioorg Chem
; 77: 600-607, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29494816
6.
Mesenchymal stem cells tune the development of monocyte-derived dendritic cells toward a myeloid-derived suppressive phenotype through growth-regulated oncogene chemokines.
J Immunol
; 190(10): 5065-77, 2013 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23589610
7.
Discovery and structure-activity relationships of phenyl benzenesulfonylhydrazides as novel indoleamine 2,3-dioxygenase inhibitors.
Bioorg Med Chem Lett
; 24(15): 3403-6, 2014 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24939758
8.
Decrypting orphan GPCR drug discovery via multitask learning.
J Cheminform
; 16(1): 10, 2024 Jan 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38263092
9.
Natural fucoidans inhibit coronaviruses by targeting viral spike protein and host cell furin.
Biochem Pharmacol
; 215: 115688, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37481137
10.
Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design.
Eur J Med Chem
; 229: 114043, 2022 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34929581
11.
Biphasic suppression of appetite by cannabinoid CB1 receptor antagonists with distinct functional activities.
Pharmacol Res
; 62(4): 337-43, 2010 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-20554040
12.
Unique Sulfur-Aromatic Interactions Contribute to the Binding of Potent Imidazothiazole Indoleamine 2,3-Dioxygenase Inhibitors.
J Med Chem
; 63(4): 1642-1659, 2020 02 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31961685
13.
1,2,3-Triazole derivatives as new cannabinoid CB1 receptor antagonists.
Bioorg Med Chem Lett
; 19(3): 1022-5, 2009 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19095444
14.
A structure-function approach identifies L-PGDS as a mediator responsible for glucocorticoid-induced leptin expression in adipocytes.
Biochem Pharmacol
; 166: 203-211, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31129049
15.
Bioisosteric replacement of the pyrazole 3-carboxamide moiety of rimonabant. A novel series of oxadiazoles as CB1 cannabinoid receptor antagonists.
Org Biomol Chem
; 6(18): 3399-407, 2008 Sep 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-18802648
16.
Caveolin-1 Secreted from Adipose Tissues and Adipocytes Functions as an Adipogenesis Enhancer.
Obesity (Silver Spring)
; 25(11): 1932-1940, 2017 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28944626
17.
Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons.
Nat Commun
; 7: 12199, 2016 07 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-27448020
18.
Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1.
J Med Chem
; 59(1): 282-93, 2016 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26642377
19.
Phenyl Benzenesulfonylhydrazides Exhibit Selective Indoleamine 2,3-Dioxygenase Inhibition with Potent in Vivo Pharmacodynamic Activity and Antitumor Efficacy.
J Med Chem
; 59(1): 419-30, 2016 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26653033
20.
Correction to Unique Sulfur-Aromatic Interactions Contribute to the Binding of Potent Imidazothiazole Indoleamine 2,3-Dioxygenase Inhibitors.
J Med Chem
; 63(13): 7445, 2020 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32573230