Detalhe da pesquisa
1.
Effect of Miricorilant, a Selective Glucocorticoid Receptor Modulator, on Olanzapine-Associated Weight Gain in Healthy Subjects: A Proof-of-Concept Study.
J Clin Psychopharmacol
; 41(6): 632-637, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34369902
2.
Corticosteroid Action in the Brain: The Potential of Selective Receptor Modulation.
Neuroendocrinology
; 109(3): 266-276, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30884490
3.
1H-Pyrazolo[3,4-g]hexahydro-isoquinolines as potent GR antagonists with reduced hERG inhibition and an improved pharmacokinetic profile.
Bioorg Med Chem Lett
; 25(24): 5720-5, 2015 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26546213
4.
The glucocorticoid receptor modulator relacorilant reverses the immunosuppressive effects of cortisol.
Int Immunopharmacol
; 120: 110312, 2023 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-37230031
5.
Peripheral glucocorticoid receptor antagonism by relacorilant with modest HPA axis disinhibition.
J Endocrinol
; 256(2)2023 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36445262
6.
Discovery of a novel non-steroidal GR antagonist with in vivo efficacy in the olanzapine-induced weight gain model in the rat.
Bioorg Med Chem Lett
; 22(24): 7376-80, 2012 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23131342
7.
Glucocorticoid receptor antagonism promotes apoptosis in solid tumor cells.
Oncotarget
; 12(13): 1243-1255, 2021 Jun 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34194622
8.
An In Vitro and In Vivo Evaluation of the Effect of Relacorilant on the Activity of Cytochrome P450 Drug Metabolizing Enzymes.
J Clin Pharmacol
; 61(2): 244-253, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32869328
9.
Glucocorticoid receptor modulators decrease alcohol self-administration in male rats.
Neuropharmacology
; 188: 108510, 2021 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33647278
10.
Identification of the Clinical Candidate (R)-(1-(4-Fluorophenyl)-6-((1-methyl-1H-pyrazol-4-yl)sulfonyl)-4,4a,5,6,7,8-hexahydro-1H-pyrazolo[3,4-g]isoquinolin-4a-yl)(4-(trifluoromethyl)pyridin-2-yl)methanone (CORT125134): A Selective Glucocorticoid Receptor (GR) Antagonist.
J Med Chem
; 60(8): 3405-3421, 2017 04 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-28368581
11.
Selection and early clinical evaluation of the brain-penetrant 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitor UE2343 (Xanamem™).
Br J Pharmacol
; 174(5): 396-408, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28012176
12.
Glucocorticoid receptor antagonism decreases alcohol seeking in alcohol-dependent individuals.
J Clin Invest
; 125(8): 3193-7, 2015 Aug 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-26121746
13.
Azepines and piperidines with dual norepinephrine dopamine uptake inhibition and antidepressant activity.
ACS Med Chem Lett
; 4(1): 46-51, 2013 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900562