Detalhe da pesquisa
1.
Discovery of N-benzylbenzamide-based allosteric inhibitors of Aurora kinase A.
Bioorg Med Chem
; 102: 117658, 2024 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38460487
2.
Discovery of 3-((3-amino-1H-indazol-4-yl)ethynyl)-N-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide (AKE-72), a potent Pan-BCR-ABL inhibitor including the T315I gatekeeper resistant mutant.
J Enzyme Inhib Med Chem
; 38(1): 2228515, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37470410
3.
Design, synthesis, and biological evaluation of novel aminopyrimidinylisoindolines as AXL kinase inhibitors.
Bioorg Med Chem Lett
; 28(23-24): 3761-3765, 2018 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30340900
4.
Systematic identification of genomic markers of drug sensitivity in cancer cells.
Nature
; 483(7391): 570-5, 2012 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-22460902
5.
Identification of TG100-115 as a new and potent TRPM7 kinase inhibitor, which suppresses breast cancer cell migration and invasion.
Biochim Biophys Acta Gen Subj
; 1861(4): 947-957, 2017 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-28161478
6.
A benzo[b]thiophene-based selective type 4 S1P receptor agonist.
Bioorg Med Chem Lett
; 27(1): 1-5, 2017 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27894870
7.
Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors.
Proc Natl Acad Sci U S A
; 111(45): E4869-77, 2014 Nov 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-25349422
8.
Identification of a novel potent CDK inhibitor degrading cyclinK with a superb activity to reverse trastuzumab-resistance in HER2-positive breast cancer in vivo.
Eur J Med Chem
; 264: 116014, 2024 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38061230
9.
Daunorubicin induces GLI1dependent apoptosis in colorectal cancer cell lines.
Int J Oncol
; 64(6)2024 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38757343
10.
Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics.
J Biol Chem
; 287(13): 9742-9752, 2012 Mar 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-22223645
11.
Identification of novel class inhibitors of NSD3 methyltransferase showing a unique, bivalent binding mode in the SET domain.
Chem Biol Drug Des
; 102(3): 500-513, 2023 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37072259
12.
Protective effects of esomeprazole against cisplatin-induced ototoxicity: an in vitro and in vivo study.
Aquat Toxicol
; 260: 106573, 2023 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-37210931
13.
Novel 2,6,9-Trisubstituted Purines as Potent CDK Inhibitors Alleviating Trastuzumab-Resistance of HER2-Positive Breast Cancers.
Pharmaceuticals (Basel)
; 15(9)2022 Aug 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36145262
14.
Discovery and optimization of potent and selective benzonaphthyridinone analogs as small molecule mTOR inhibitors with improved mouse microsome stability.
Bioorg Med Chem Lett
; 21(13): 4036-40, 2011 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21621413
15.
Clinical stage EGFR inhibitors irreversibly alkylate Bmx kinase.
Bioorg Med Chem Lett
; 18(22): 5916-9, 2008 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18667312
16.
Amphiphilic small peptides for delivery of plasmid DNAs and siRNAs.
Chem Biol Drug Des
; 91(2): 575-587, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29052961
17.
First SAR Study for Overriding NRAS Mutant Driven Acute Myeloid Leukemia.
J Med Chem
; 61(18): 8353-8373, 2018 09 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30153003
18.
Design, synthesis and biological evaluation of novel thiazolidinedione derivatives as irreversible allosteric IKK-ß modulators.
Eur J Med Chem
; 157: 691-704, 2018 Sep 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30130718
19.
Identification of the First Selective Activin Receptor-Like Kinase 1 Inhibitor, a Reversible Version of L-783277.
J Med Chem
; 60(4): 1495-1508, 2017 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28103025
20.
Structure-activity relationship investigation for benzonaphthyridinone derivatives as novel potent Bruton's tyrosine kinase (BTK) irreversible inhibitors.
Eur J Med Chem
; 137: 545-557, 2017 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28628824