Detalhe da pesquisa
1.
Synthesis and optimization of N-heterocyclic pyridinones as catechol-O-methyltransferase (COMT) inhibitors.
Bioorg Med Chem Lett
; 26(12): 2952-2956, 2016 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27133481
2.
The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 attenuates a scopolamine-induced deficit in a novel rodent attention task.
J Neurogenet
; 25(4): 120-6, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-22070409
3.
3-Aryl-5-phenoxymethyl-1,3-oxazolidin-2-ones as positive allosteric modulators of mGluR2 for the treatment of schizophrenia: Hit-to-lead efforts.
Bioorg Med Chem Lett
; 20(10): 3129-33, 2010 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20409708
4.
The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors.
Bioorg Med Chem Lett
; 18(11): 3386-91, 2008 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18455394
5.
Synthesis and Evaluation of Heterocyclic Catechol Mimics as Inhibitors of Catechol-O-methyltransferase (COMT).
ACS Med Chem Lett
; 6(3): 318-23, 2015 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-25815153
6.
Selective orexin 2 receptor antagonism blocks cue-induced reinstatement, but not nicotine self-administration or nicotine-induced reinstatement.
Behav Brain Res
; 269: 61-5, 2014 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24746488
7.
A randomized, double-blind, crossover comparison of MK-0929 and placebo in the treatment of adults with ADHD.
J Atten Disord
; 16(8): 664-74, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-22090395
8.
T-type calcium channel antagonism produces antipsychotic-like effects and reduces stimulant-induced glutamate release in the nucleus accumbens of rats.
Neuropharmacology
; 62(3): 1413-21, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-21110986
9.
Differential effects of the mGluR5 positive allosteric modulator CDPPB in the cortex and striatum following repeated administration.
Neuropharmacology
; 62(3): 1453-60, 2012 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-21112344
10.
Characterization of non-nitrocatechol pan and isoform specific catechol-O-methyltransferase inhibitors and substrates.
ACS Chem Neurosci
; 3(2): 129-40, 2012 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22860182
11.
Inhibition of glycine transporter 1 attenuates nicotine- but not food-induced cue-potentiated reinstatement for a response previously paired with sucrose.
Behav Brain Res
; 207(1): 37-43, 2010 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-19799936
12.
T-type calcium channel antagonism decreases motivation for nicotine and blocks nicotine- and cue-induced reinstatement for a response previously reinforced with nicotine.
Biol Psychiatry
; 68(8): 712-8, 2010 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20579972
13.
Discovery of Oxazolobenzimidazoles as Positive Allosteric Modulators for the mGluR2 Receptor.
ACS Med Chem Lett
; 1(8): 406-10, 2010 Nov 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900224
14.
Dose-dependent effect of CDPPB, the mGluR5 positive allosteric modulator, on recognition memory is associated with GluR1 and CREB phosphorylation in the prefrontal cortex and hippocampus.
Neuropharmacology
; 57(5-6): 531-8, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19627999
15.
Combined administration of an mGlu2/3 receptor agonist and a 5-HT 2A receptor antagonist markedly attenuate the psychomotor-activating and neurochemical effects of psychostimulants.
Psychopharmacology (Berl)
; 206(4): 641-51, 2009 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-19707745
16.
Postnatal development and kinetics of [3H]gaboxadol binding in rat brain: in vitro homogenate binding and quantitative autoradiography.
Brain Res
; 1170: 39-47, 2007 Sep 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-17692833
17.
N-Methyl-D-aspartate receptor subtype-selectivity of homoquinolinate: an electrophysiological and radioligand binding study using both native and recombinant receptors.
J Neurochem
; 82(4): 794-800, 2002 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-12358784