Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer's Disease.

Wesseling, Hendrik; Mair, Waltraud; Kumar, Mukesh; Schlaffner, Christoph N; Tang, Shaojun; Beerepoot, Pieter; Fatou, Benoit; Guise, Amanda J; Cheng, Long; Takeda, Shuko; Muntel, Jan; Rotunno, Melissa S; Dujardin, Simon; Davies, Peter; Kosik, Kenneth S; Miller, Bruce L; Berretta, Sabina; Hedreen, John C; Grinberg, Lea T; Seeley, William W; Hyman, Bradley T; Steen, Hanno; Steen, Judith A.

Cell ; 183(6): 1699-1713.e13, 2020 12 10.

Artigo em Inglês | MEDLINE | ID: mdl-33188775

2.

Somatic genomic changes in single Alzheimer's disease neurons.

Miller, Michael B; Huang, August Yue; Kim, Junho; Zhou, Zinan; Kirkham, Samantha L; Maury, Eduardo A; Ziegenfuss, Jennifer S; Reed, Hannah C; Neil, Jennifer E; Rento, Lariza; Ryu, Steven C; Ma, Chanthia C; Luquette, Lovelace J; Ames, Heather M; Oakley, Derek H; Frosch, Matthew P; Hyman, Bradley T; Lodato, Michael A; Lee, Eunjung Alice; Walsh, Christopher A.

Nature ; 604(7907): 714-722, 2022 04.

Artigo em Inglês | MEDLINE | ID: mdl-35444284

3.

LRP1 is a master regulator of tau uptake and spread.

Rauch, Jennifer N; Luna, Gabriel; Guzman, Elmer; Audouard, Morgane; Challis, Collin; Sibih, Youssef E; Leshuk, Carolina; Hernandez, Israel; Wegmann, Susanne; Hyman, Bradley T; Gradinaru, Viviana; Kampmann, Martin; Kosik, Kenneth S.

Nature ; 580(7803): 381-385, 2020 04.

Artigo em Inglês | MEDLINE | ID: mdl-32296178

4.

SORL1 is a receptor for tau that promotes tau seeding.

Cooper, Joanna M; Lathuiliere, Aurelien; Su, Enming J; Song, Yuyu; Torrente, Daniel; Jo, Youhwa; Weinrich, Nicholas; Sales, Jennifer Diaz; Migliorini, Mary; Sisson, Thomas H; Lawrence, Daniel A; Hyman, Bradley T; Strickland, Dudley K.

J Biol Chem ; 300(6): 107313, 2024 Apr 23.

Artigo em Inglês | MEDLINE | ID: mdl-38657864

5.

All the Tau We Cannot See.

Hyman, Bradley.

Annu Rev Med ; 74: 503-514, 2023 01 27.

Artigo em Inglês | MEDLINE | ID: mdl-36378913

6.

Report of the APOE4 National Institute on Aging/Alzheimer Disease Sequencing Project Consortium Working Group: Reducing APOE4 in Carriers is a Therapeutic Goal for Alzheimer's Disease.

Vance, Jeffery M; Farrer, Lindsay A; Huang, Yadong; Cruchaga, Carlos; Hyman, Bradley T; Pericak-Vance, Margaret A; Goate, Alison M; Greicius, Michael D; Griswold, Anthony J; Haines, Jonathan L; Tcw, Julia; Schellenberg, Gerard D; Tsai, Li-Huei; Herz, Joachim; Holtzman, David M.

Ann Neurol ; 95(4): 625-634, 2024 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-38180638

7.

Alzheimer proteopathic tau seeds are biochemically a forme fruste of mature paired helical filaments.

Kumar, Mukesh; Quittot, Noé; Dujardin, Simon; Schlaffner, Christoph N; Viode, Arthur; Wiedmer, Anne; Beerepoot, Pieter; Chun, Joshua E; Glynn, Calina; Fernandes, Analiese R; Donahue, Cameron; Steen, Judith A; Hyman, Bradley T.

Brain ; 147(2): 637-648, 2024 02 01.

Artigo em Inglês | MEDLINE | ID: mdl-38236720

8.

Utility of cortical tissue analysis in normal pressure hydrocephalus.

Greenberg, Ana B W; Mekbib, Kedous Y; Mehta, Neel H; Kiziltug, Emre; Duy, Phan Q; Smith, Hannah R; Junkkari, Antti; Leinonen, Ville; Hyman, Bradley T; Chan, Diane; Curry, William T; Arnold, Steven E; Barker Ii, Frederick G; Frosch, Matthew P; Kahle, Kristopher T.

Cereb Cortex ; 34(2)2024 01 31.

Artigo em Inglês | MEDLINE | ID: mdl-38275188

9.

APOE2 gene therapy reduces amyloid deposition and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease.

Jackson, Rosemary J; Keiser, Megan S; Meltzer, Jonah C; Fykstra, Dustin P; Dierksmeier, Steven E; Hajizadeh, Soroush; Kreuzer, Johannes; Morris, Robert; Melloni, Alexandra; Nakajima, Tsuneo; Tecedor, Luis; Ranum, Paul T; Carrell, Ellie; Chen, YongHong; Nishtar, Maryam A; Holtzman, David M; Haas, Wilhelm; Davidson, Beverly L; Hyman, Bradley T.

Mol Ther ; 32(5): 1373-1386, 2024 May 01.

Artigo em Inglês | MEDLINE | ID: mdl-38504517

10.

Endothelial Cells Are Heterogeneous in Different Brain Regions and Are Dramatically Altered in Alzheimer's Disease.

Bryant, Annie; Li, Zhaozhi; Jayakumar, Rojashree; Serrano-Pozo, Alberto; Woost, Benjamin; Hu, Miwei; Woodbury, Maya E; Wachter, Astrid; Lin, Gen; Kwon, Taekyung; Talanian, Robert V; Biber, Knut; Karran, Eric H; Hyman, Bradley T; Das, Sudeshna; Bennett, Rachel E.

J Neurosci ; 43(24): 4541-4557, 2023 06 14.

Artigo em Inglês | MEDLINE | ID: mdl-37208174

11.

Reconstitution of the Alzheimer's Disease Tau Core Structure from Recombinant Tau^297-391 Yields Variable Quaternary Structures as Seen by Negative Stain and Cryo-EM.

Glynn, Calina; Chun, Joshua E; Donahue, Cameron C; Nadler, Monica J S; Fan, Zhanyun; Hyman, Bradley T.

Biochemistry ; 63(2): 194-201, 2024 Jan 16.

Artigo em Inglês | MEDLINE | ID: mdl-38154792

12.

Characterization of monoamine oxidase-B (MAO-B) as a biomarker of reactive astrogliosis in Alzheimer's disease and related dementias.

Jaisa-Aad, Methasit; Muñoz-Castro, Clara; Healey, Molly A; Hyman, Bradley T; Serrano-Pozo, Alberto.

Acta Neuropathol ; 147(1): 66, 2024 Apr 03.

Artigo em Inglês | MEDLINE | ID: mdl-38568475

13.

Brain vasculature accumulates tau and is spatially related to tau tangle pathology in Alzheimer's disease.

Hoglund, Zachary; Ruiz-Uribe, Nancy; Del Sastre, Eric; Woost, Benjamin; Bader, Elizabeth; Bailey, Joshua; Hyman, Bradley T; Zwang, Theodore; Bennett, Rachel E.

Acta Neuropathol ; 147(1): 101, 2024 Jun 17.

Artigo em Inglês | MEDLINE | ID: mdl-38884806

14.

Neuronal STING activation in amyotrophic lateral sclerosis and frontotemporal dementia.

Marques, Christine; Held, Aaron; Dorfman, Katherine; Sung, Joon; Song, Catherine; Kavuturu, Amey S; Aguilar, Corey; Russo, Tommaso; Oakley, Derek H; Albers, Mark W; Hyman, Bradley T; Petrucelli, Leonard; Lagier-Tourenne, Clotilde; Wainger, Brian J.

Acta Neuropathol ; 147(1): 56, 2024 Mar 13.

Artigo em Inglês | MEDLINE | ID: mdl-38478117

15.

Landscape of brain myeloid cell transcriptome along the spatiotemporal progression of Alzheimer's disease reveals distinct sequential responses to Aß and tau.

Wachter, Astrid; Woodbury, Maya E; Lombardo, Sylvia; Abdourahman, Aicha; Wuest, Carolin; McGlame, Emily; Pastika, Timothy; Tamm, Joseph; Romanul, Nandini; Yanamandra, Kiran; Bennett, Rachel; Lin, Gen; Kwon, Taekyung; Liao, Fan; Klein, Corinna; Grinberg, Yelena; Jaisa-Aad, Methasit; Li, Huan; Frosch, Matthew P; Kummer, Markus P; Das, Sudeshna; Dellovade, Tammy; Karran, Eric H; Langlois, Xavier; Ried, Janina S; Serrano-Pozo, Alberto; Talanian, Robert V; Biber, Knut; Hyman, Bradley T.

Acta Neuropathol ; 147(1): 65, 2024 Apr 01.

Artigo em Inglês | MEDLINE | ID: mdl-38557897

16.

Cryptic splicing of stathmin-2 and UNC13A mRNAs is a pathological hallmark of TDP-43-associated Alzheimer's disease.

Agra Almeida Quadros, Ana Rita; Li, Zhaozhi; Wang, Xue; Ndayambaje, I Sandra; Aryal, Sandeep; Ramesh, Nandini; Nolan, Matthew; Jayakumar, Rojashree; Han, Yi; Stillman, Hannah; Aguilar, Corey; Wheeler, Hayden J; Connors, Theresa; Lopez-Erauskin, Jone; Baughn, Michael W; Melamed, Ze'ev; Beccari, Melinda S; Olmedo Martínez, Laura; Canori, Michael; Lee, Chao-Zong; Moran, Laura; Draper, Isabelle; Kopin, Alan S; Oakley, Derek H; Dickson, Dennis W; Cleveland, Don W; Hyman, Bradley T; Das, Sudeshna; Ertekin-Taner, Nilüfer; Lagier-Tourenne, Clotilde.

Acta Neuropathol ; 147(1): 9, 2024 Jan 04.

Artigo em Inglês | MEDLINE | ID: mdl-38175301

17.

Beyond the neuron-cellular interactions early in Alzheimer disease pathogenesis.

Henstridge, Christopher M; Hyman, Bradley T; Spires-Jones, Tara L.

Nat Rev Neurosci ; 20(2): 94-108, 2019 02.

Artigo em Inglês | MEDLINE | ID: mdl-30643230

18.

Toxic effects of mutant huntingtin in axons are mediated by its proline-rich domain.

Brady, Scott T; Mesnard-Hoaglin, Nichole A; Priego, Mercedes; Dziechciowska, Joanna; Morris, Sarah; Kang, Minsu; Tsai, Ming Ying; Purks, Jennifer L; Klein, Alison; Gaona, Angelica; Melloni, Alexandra; Connors, Theresa; Hyman, Bradley; Song, Yuyu; Morfini, Gerardo A.

Brain ; 2023 Aug 26.

Artigo em Inglês | MEDLINE | ID: mdl-37633260

19.

Cases of familial idiopathic normal pressure hydrocephalus implicate genetic factors in disease pathogenesis.

Greenberg, Ana B W; Mehta, Neel H; Mekbib, Kedous Y; Kiziltug, Emre; Smith, Hannah R; Hyman, Bradley T; Chan, Diane; Curry, William T; Arnold, Steven E; Frosch, Matthew P; Duy, Phan Q; Kahle, Kristopher T.

Cereb Cortex ; 33(23): 11400-11407, 2023 11 27.

Artigo em Inglês | MEDLINE | ID: mdl-37814356

20.

Distinct transcriptomic responses to Aß plaques, neurofibrillary tangles, and APOE in Alzheimer's disease.

Das, Sudeshna; Li, Zhaozhi; Wachter, Astrid; Alla, Srinija; Noori, Ayush; Abdourahman, Aicha; Tamm, Joseph A; Woodbury, Maya E; Talanian, Robert V; Biber, Knut; Karran, Eric H; Hyman, Bradley T; Serrano-Pozo, Alberto.

Alzheimers Dement ; 20(1): 74-90, 2024 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-37461318

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