RESUMO
Sudden cardiac death (SCD) is a combined conception integrating various nosological forms of cardiac pathology. 80% of SCD cause is coronary heart disease, 20% are various cardiomyopathies, myocarditis, cardiovascular malformations and other rare diseases. One of cardiomyopathies is arrhythmogenic right ventricle cardiomyopathy or arrhythmogenic dysplasia of right ventricle.
Assuntos
Displasia Arritmogênica Ventricular Direita , Eletrocardiografia , Marcadores Genéticos/genética , Displasia Arritmogênica Ventricular Direita/diagnóstico , Displasia Arritmogênica Ventricular Direita/genética , Displasia Arritmogênica Ventricular Direita/fisiopatologia , Diagnóstico Diferencial , Predisposição Genética para Doença , Humanos , Prognóstico , Função Ventricular Direita/fisiologiaRESUMO
Sudden death (SD) rate acquires threatening dimensions in industrialized countries. Upon the average SD rate is about 1 case of 1000 citizens. According to the SD patients autopsy results 85% had coronary heart disease, 10% had other cardiac pathology and 5% did not have any organic heart pathology. One of the SD causes in patients without organic cardiac pathology can be "channelpathy" - clinico-electrocardiographic syndromes, caused by disturbances of ion channel functions.
Assuntos
Morte Súbita/etiologia , Eletrocardiografia , Cardiopatias/fisiopatologia , Morte Súbita/epidemiologia , Saúde Global , Cardiopatias/complicações , Cardiopatias/metabolismo , Humanos , Incidência , Canais Iônicos/metabolismo , Miocárdio/metabolismo , Fatores de RiscoRESUMO
Intracardiac asynchronism presents systolic and/or diastolic dyscoordination in different myocardial areas within one and/or between different cardiac chambers. QRS complex widening is the marker of electric asynchronism. In 1/3 of patients with chronic cardiac insufficiency (CCI), the width of QRS complex is more than 120 msec. sixty-five CCI patients (56 men aged 63.7 +/- 7.3 years and 9 women aged 66.8 +/- 8.2 years) were divided into two groups: the group with a wide QRS (more than 120 msec) and the group with a narrow QRS (less than 120 msec), 30 and 35 patients, respectively. In the group with a wide QRS, 96.6% of patients suffered from clinically significant CCI (functional class III to IV); in the other group it was observed in 65.7% of patients. The patients were observed during three years. CCI dynamics was evaluated, quality of life was assessed using the Russian version of SF questionnaire, and three-year survival rate was assessed by Kaplan-Meyer method. The presence of electric asynchronism in a form of a wide QRS complex promotes CCI progression, accompanied by CCI functional class deterioration as well as clinical worsening and decreased physical exercise tolerance according to 6-min walking test. The frequency of seeking medical aid was significantly higher among patients with a wide QRS complex.