Acute and chronic effect of sprint interval training combined with postexercise blood-flow restriction in trained individuals.

This investigation assessed the efficacy of sprint interval training (SIT) combined with postexercise blood-flow restriction as a novel approach to enhance maximal aerobic physiology and performance. In study 1, a between-groups design was used to determine whether 4 weeks (2 days per week) of SIT (repeated 30 s maximal sprint cycling) combined with postexercise blood-flow restriction (BFR) enhanced maximal oxygen uptake (V̇(O2max)) and 15 km cycling time-trial performance (15 km TT) compared with SIT alone (CON) in trained individuals. The V̇(O2max) increased after BFR by 4.5% (P = 0.01) but was unchanged after CON. There was no difference in 15 km TT performance after CON or BFR. In study 2, using a repeated-measures design, participants performed an acute bout of either BFR or CON. Muscle biopsies were taken before and after exercise to examine the activation of signalling pathways regulating angiogenesis and mitochondrial biogenesis. Phosphorylation of p38MAPK(Thr180/Tyr182) increased by a similar extent after CON and BFR. There was no difference in the magnitude of increase in PGC-1α, VEGF and VEGFR-2 mRNA expression between protocols; however, HIF-1α mRNA expression increased (P = 0.04) at 3 h only after BFR. We have demonstrated the potency of combining BFR with SIT in increasing V̇(O2max) in trained individuals, but this did not translate to an enhanced exercise performance. Sprint interval training alone did not induce any observable adaptation. Although the mechanisms are not fully understood, we present preliminary evidence that BFR leads to enhanced HIF-1α-mediated cell signalling.

Exercise duration-matched interval and continuous sprint cycling induce similar increases in AMPK phosphorylation, PGC-1α and VEGF mRNA expression in trained individuals.

PURPOSE: The effects of low-volume interval and continuous 'all-out' cycling, matched for total exercise duration, on mitochondrial and angiogenic cell signalling was investigated in trained individuals. METHODS: In a repeated measures design, 8 trained males ([Formula: see text], 57 ± 7 ml kg(-1) min(-1)) performed two cycling exercise protocols; interval (INT, 4 × 30 s maximal sprints interspersed by 4 min passive recovery) or continuous (CON, 2 min continuous maximal sprint). Muscle biopsies were obtained before, immediately after and 3 h post-exercise. RESULTS: Total work was 53 % greater (P = 0.01) in INT compared to CON (71.2 ± 7.3 vs. 46.3 ± 2.7 kJ, respectively). Phosphorylation of AMPK(Thr172) increased by a similar magnitude (P = 0.347) immediately post INT and CON (1.6 ± 0.2 and 1.3 ± 0.3 fold, respectively; P = 0.011), before returning to resting values at 3 h post-exercise. mRNA expression of PGC-1α (7.1 ± 2.1 vs. 5.5 ± 1.8 fold; P = 0.007), VEGF (3.5 ± 1.2 vs. 4.3 ± 1.8 fold; P = 0.02) and HIF-1α (2.0 ± 0.5 vs. 1.5 ± 0.3 fold; P = 0.04) increased at 3 h post-exercise in response to INT and CON, respectively; the magnitude of which were not different between protocols. CONCLUSIONS: Despite differences in total work done, low-volume INT and CON 'all-out' cycling, matched for exercise duration, provides a similar stimulus for the induction of mitochondrial and angiogenic cell signalling pathways in trained skeletal muscle.

Altitude training for elite endurance performance: a 2012 update.

Altitude training is commonly used by endurance athletes and coaches in pursuit of enhancement of performance on return to sea level. The purpose of the current review article was to update and evaluate recent literature relevant to the practical application of altitude training for endurance athletes. Consequently, the literature can be considered in either of two categories: performance-led investigations or mechanistic advancements/insights. Each section discusses the relevant literature and proposes future directions where appropriate.

Effect of a concentric warm-up exercise on eccentrically induced soreness and loss of function of the elbow flexor muscles.

The aim of this study was to examine the effect of concentric warm-up exercise on eccentrically induced changes in muscle strength, range of motion, and soreness of the elbow flexors. Ten resistance-exercise naive participants performed intermittent incremental eccentric actions (42 in total) of the elbow flexor muscles of each arm to induce muscle damage. The arms of each participant were randomly assigned either to a pre-eccentric exercise warm-up involving intermittent concentric exercise (warm-up) or no prior exercise (control). Strength, range of motion, and ratings of soreness were recorded before and 1, 2, 3, 4, and 7 days after exercise. Strength, range of motion, and soreness during muscular movements changed over time (P at most 0.01; Cohen's d at least 0.51, medium). There was an interaction (P < 0.001) for strength, showing a smaller reduction after exercise for warm-up than control (P < 0.001, d = 2.44, large effect). The decreased range of motion was less for warm-up than control for the arm while extended (P < 0.001), flexed (P = 0.002), and relaxed (P = 0.004). Muscle soreness was reduced for the warm-up group, while the muscle was flexed, extended, and relaxed compared with control (P < 0.001). The results demonstrate that a concentric warm-up exercise attenuates the reduction in loss of strength, range of motion, and muscle soreness after eccentric-exercise-induced muscle damage and might allow higher intensities of training to be performed.

Physiological and performance effects of low- versus mixed-intensity rowing training.

PURPOSE: To examine the impact of low-intensity and a mixture of low- and high-intensity training on physiological and performance responses in rowing. METHODS: Eighteen experienced rowers undertook a 12-wk program of 100% < or = lactate threshold (LT) training (LOW) or 70% training at < or = LT and 30% at halfway (50%Delta) between the V O2 at LT and V O2peak (MIX). Responses were assessed before and after training by a progressive exercise test to exhaustion; multiple "square-wave" rest-to-exercise transitions of 6-min duration at 50%Delta; and a maximal 2000-m ergometer time trial. RESULTS: Improvements (P < 0.001) in 2000-m ergometer performance and V O2peak occurred independently of groups (P = 0.8 and 0.42, respectively). LOW improved the power at LT (23.5 +/- 12.2 vs 5.1 +/- 5.0 W, P = 0.013) and power at a [blood lactate] of 4 mM (32.3 +/- 6.9 vs 13.1 +/- 3.7 W, P = 0.03) compared with MIX. The time constant and gain of the primary component were unchanged with training, whereas the gain of the V O2 slow component was reduced with training, but independently of group. CONCLUSIONS: Both LOW and MIX training programs improved performance and V O2peak by the same magnitude, whereas LOW attenuated the blood lactate response to a given exercise intensity more so than MIX.

Determinants of 800-m and 1500-m running performance using allometric models.

PURPOSE: To identify the optimal aerobic determinants of elite, middle-distance running (MDR) performance, using proportional allometric models. METHODS: Sixty-two national and international male and female 800-m and 1500-m runners undertook an incremental exercise test to volitional exhaustion. Mean submaximal running economy (ECON), speed at lactate threshold (speedLT), maximum oxygen uptake (.VO(2max)), and speed associated with .VO(2max) (speed.VO(2max)) were paired with best performance times recorded within 30 d. The data were analyzed using a proportional power-function ANCOVA model. RESULTS: The analysis identified significant differences in running speeds with main effects for sex and distance, with .VO(2max) and ECON as the covariate predictors (P < 0.0001). The results suggest a proportional curvilinear association between running speed and the ratio (.VO(2max).ECON(-0.71))(0.35) explaining 95.9% of the variance in performance. The model was cross-validated with a further group of highly trained MDR, demonstrating strong agreement (95% limits, 0.05 +/- 0.29 m.s(-1)) between predicted and actual performance speeds (R(2) = 93.6%). The model indicates that for a male 1500-m runner with a .VO(2max) of 3.81 L.min(-1) and ECON of 15 L.km(-1) to improve from 250 to 240 s, it would require a change in .VO(2max) from 3.81 to 4.28 L.min(-1), an increase of Delta0.47 L.min(-1). However, improving by the same margin of 10 s from 225 to 215 s would require a much greater increase in .VO(2max), from 5.14 to 5.85 L.min(-1), an increase of Delta0.71 L.min(-1) (where ECON remains constant). CONCLUSION: A proportional curvilinear ratio of .VO(2max) divided by ECON explains 95.9% of the variance in MDR performance.

The efficacy of downhill running as a method to enhance running economy in trained distance runners.

Running downhill, in comparison to running on the flat, appears to involve an exaggerated stretch-shortening cycle (SSC) due to greater impact loads and higher vertical velocity on landing, whilst also incurring a lower metabolic cost. Therefore, downhill running could facilitate higher volumes of training at higher speeds whilst performing an exaggerated SSC, potentially inducing favourable adaptations in running mechanics and running economy (RE). This investigation assessed the efficacy of a supplementary 8-week programme of downhill running as a means of enhancing RE in well-trained distance runners. Nineteen athletes completed supplementary downhill (-5% gradient; n = 10) or flat (n = 9) run training twice a week for 8 weeks within their habitual training. Participants trained at a standardised intensity based on the velocity of lactate turnpoint (vLTP), with training volume increased incrementally between weeks. Changes in energy cost of running (EC) and vLTP were assessed on both flat and downhill gradients, in addition to maximal oxygen uptake (⩒O2max). No changes in EC were observed during flat running following downhill (1.22 ± 0.09 vs 1.20 ± 0.07 Kcal kg-1 km-1, P = .41) or flat run training (1.21 ± 0.13 vs 1.19 ± 0.12 Kcal kg-1 km-1). Moreover, no changes in EC during downhill running were observed in either condition (P > .23). vLTP increased following both downhill (16.5 ± 0.7 vs 16.9 ± 0.6 km h-1, P = .05) and flat run training (16.9 ± 0.7 vs 17.2 ± 1.0 km h-1, P = .05), though no differences in responses were observed between groups (P = .53). Therefore, a short programme of supplementary downhill run training does not appear to enhance RE in already well-trained individuals.

Comparison of the oxygen uptake kinetics of club and olympic champion rowers.

PURPOSE: To test the hypothesis that elite rowers would possess a faster, more economic oxygen uptake response than club standard rowers. METHODS: Eight Olympic champion (ELITE) rowers were compared with a cohort of eight club standard (CLUB) rowers. Participants completed a progressive exercise test to exhaustion, repeated 6-min moderate and heavy square-wave transitions, and a maximal 2000-m ergometer time trial. RESULTS: The time constant (tau) of the primary component (PC) was faster for the ELITE group compared with CLUB for moderate-intensity (13.9 vs 19.4 s, P = 0.02) and heavy-intensity (18.7 vs 22.4 s, P = 0.005) exercise. ELITE rowers consumed less oxygen for moderate (14.2 vs 15.6 mL x min(-1) x W(-1); P = 0.009) and heavy (12.1 vs 13.7 mL x min(-1) x W(-1); P = 0.01) exercise. A greater absolute slow component was observed in the ELITE group (P = 0.009), but no differences were noted when the slow component was expressed relative to work rate performed (P = 0.14). Intergroup correlation with time trial performance speed was significant for tauPC during heavy-intensity exercise (r = -0.59, P = 0.02). CONCLUSIONS: Compared with CLUB rowers, the shorter time constant response and greater economy observed in ELITE rowers may suggest advantageous adjustment of oxidative processes from rest to work. Training status or performance level do not seem to be associated with a smaller slow component when comparing CLUB and ELITE oarsmen.

The correlation between running economy and maximal oxygen uptake: cross-sectional and longitudinal relationships in highly trained distance runners.

A positive relationship between running economy and maximal oxygen uptake (V̇O2max) has been postulated in trained athletes, but previous evidence is equivocal and could have been confounded by statistical artefacts. Whether this relationship is preserved in response to running training (changes in running economy and V̇O2max) has yet to be explored. This study examined the relationships of (i) running economy and V̇O2max between runners, and (ii) the changes in running economy and V̇O2max that occur within runners in response to habitual training. 168 trained distance runners (males, n = 98, V̇O2max 73.0 ± 6.3 mL∙kg-1∙min-1; females, n = 70, V̇O2max 65.2 ± 5.9 mL kg-1∙min-1) performed a discontinuous submaximal running test to determine running economy (kcal∙km-1). A continuous incremental treadmill running test to volitional exhaustion was used to determine V̇O2max 54 participants (males, n = 27; females, n = 27) also completed at least one follow up assessment. Partial correlation analysis revealed small positive relationships between running economy and V̇O2max (males r = 0.26, females r = 0.25; P<0.006), in addition to moderate positive relationships between the changes in running economy and V̇O2max in response to habitual training (r = 0.35; P<0.001). In conclusion, the current investigation demonstrates that only a small to moderate relationship exists between running economy and V̇O2max in highly trained distance runners. With >85% of the variance in these parameters unexplained by this relationship, these findings reaffirm that running economy and V̇O2max are primarily determined independently.

Tapering strategies in elite British endurance runners.

The aim of the study was to explore pre-competition training practices of elite endurance runners. Training details from elite British middle distance (MD; 800 m and 1500 m), long distance (LD; 3000 m steeplechase to 10,000 m) and marathon (MAR) runners were collected by survey for 7 days in a regular training (RT) phase and throughout a pre-competition taper. Taper duration was [median (interquartile range)] 6 (3) days in MD, 6 (1) days in LD and 14 (8) days in MAR runners. Continuous running volume was reduced to 70 (16)%, 71 (24)% and 53 (12)% of regular levels in MD, LD and MAR runners, respectively (P < 0.05). Interval running volume was reduced compared to regular training (MD; 53 (45)%, LD; 67 (23)%, MAR; 64 (34)%, P < 0.05). During tapering, the peak interval training intensity was above race speed in LD and MAR runners (112 (27)% and 114 (3)%, respectively, P < 0.05), but not different in MD (100 (2)%). Higher weekly continuous running volume and frequency in RT were associated with greater corresponding reductions during the taper (R = -0.70 and R = -0.63, respectively, both P < 0.05). Running intensity during RT was positively associated with taper running intensity (continuous intensity; R = 0.97 and interval intensity; R = 0.81, both P < 0.05). Algorithms were generated to predict and potentially prescribe taper content based on the RT of elite runners. In conclusion, training undertaken prior to the taper in elite endurance runners is predictive of the tapering strategy implemented before competition.

The valid measurement of running economy in runners.

UNLABELLED: Oxygen cost (OC) is commonly used to assess an athlete's running economy, although the validity of this measure is often overlooked. PURPOSE: This study evaluated the validity of OC as a measure of running economy by comparison with the underlying energy cost (EC). In addition, the most appropriate method of removing the influence of body mass was determined to elucidate a measure of running economy that enables valid interindividual comparisons. METHODS: One hundred and seventy-two highly trained endurance runners (males, n = 101; females, n = 71) performed a discontinuous submaximal running assessment, consisting of approximately seven 3-min stages (1 km·h increments), to determine the absolute OC (L·km) and EC (kcal·km) for the four speeds below lactate turn point. RESULTS: Comparisons between models revealed linear ratio scaling to be a more suitable method than power function scaling for removing the influence of body mass for both EC (males, R = 0.589 vs 0.588; females, R = 0.498 vs 0.482) and OC (males, R = 0.657 vs 0.652; females, R = 0.532 vs 0.531). There were stepwise increases in EC and RER with increments in running speed (both, P < 0.001). However, no differences were observed for OC across the four monitored speeds (P = 0.54). CONCLUSIONS: Although EC increased with running speed, OC was insensitive to changes in running speed and, therefore, does not appear to provide a valid index of the underlying EC of running, likely due to the inability of OC to account for variations in substrate use. Therefore, EC should be used as the primary measure of running economy, and for runners, an appropriate scaling with body mass is recommended.

Improvement of 800-m running performance with prior high-intensity exercise.

UNLABELLED: Prior high-intensity exercise increases the oxidative energy contribution to subsequent exercise and may enhance exercise tolerance. The potential impact of a high-intensity warm-up on competitive performance, however, has not been investigated. PURPOSE: To test the hypothesis that a high-intensity warm-up would speed VO2 kinetics and enhance 800-m running performance in well-trained athletes. METHODS: Eleven highly trained middle-distance runners completed two 800-m time trials on separate days on an indoor track, preceded by 2 different warm-up procedures. The 800-m time trials were preceded by a 10-min self-paced jog and standardized mobility drills, followed by either 6 × 50-m strides (control [CON]) or 2 × 50-m strides and a continuous high-intensity 200-m run (HWU) at race pace. Blood [La] was measured before the time trials, and VO2 was measured breath by breath throughout exercise. RESULTS: 800-m time-trial performance was significantly faster after HWU (124.5 ± 8.3 vs CON, 125.7 ± 8.7 s, P < .05). Blood [La] was greater after HWU (3.6 ± 1.9 vs CON, 1.7 ± 0.8 mM; P < .01). The mean response time for VO2 was not different between conditions (HWU, 27 ± 6 vs CON, 28 ± 7 s), but total O2 consumed (HWU, 119 ± 18 vs CON, 109 ± 28 ml/kg, P = .05) and peak VO2 attained (HWU, 4.21 ± 0.85 vs CON, 3.91 ± 0.63 L/min; P = .08) tended to be greater after HWU. CONCLUSIONS: These data indicate that a sustained high-intensity warm-up enhances 800-m time-trial performance in trained athletes.

Comparison of step-wise and ramp-wise incremental rowing exercise tests and 2000-m rowing ergometer performance.

PURPOSE: This study examined parameters derived from both an incremental step-wise and a ramp-wise graded rowing exercise test in relation to rowing performance. METHODS: Discontinuous step-wise incremental rowing to exhaustion established lactate threshold (LT), maximum oxygen consumption (VO(2maxSTEP)), and power associated with VO(2max) (W VO(2max)). A further continuous ramp-wise test was undertaken to derive ventilatory threshold (VT), maximum oxygen consumption (VO(2maxRAMP)), and maximum minute power (MMW). Results were compared with maximal 2000-m ergometer time-trial power. RESULTS: The strongest correlation with 2000-m power was observed for MMW (r = .98, P < .001), followed by W VO(2max) (r = .96; P < .001). The difference between MMW and W VO(2max) compared with the mean of MMW/W VO(2max) showed a widening bias with a greater difference coincident with greater power. However, this bias was reduced when expressed as a ratio term and when a baseline VO2 was accounted for. There were no differences (P = .85) between measures of VO(2maxSTEP) and VO(2maxRAMP); rather, the measures showed strong association (r = .97, P < .001, limits of agreement = -0.43 to 0.33 L/min). The power at LT and VT did not differ (P = .6), and a significant association was observed (r = .73, P = .001, limits of agreement = -54.3 to 20.2 W, SEE = 26.1). CONCLUSIONS: This study indicates that MMW demonstrates a strong association with ergometer rowing performance and thus may have potential as an influential monitoring tool for rowing athletes.

The reliability of running economy expressed as oxygen cost and energy cost in trained distance runners.

This study assessed the between-test reliability of oxygen cost (OC) and energy cost (EC) in distance runners, and contrasted it with the smallest worthwhile change (SWC) of these measures. OC and EC displayed similar levels of within-subject variation (typical error < 3.85%). However, the typical error (2.75% vs 2.74%) was greater than the SWC (1.38% vs 1.71%) for both OC and EC, respectively, indicating insufficient sensitivity to confidently detect small, but meaningful, changes in OC and EC.

Training distribution, physiological profile, and performance for a male international 1500-m runner.

This case study observed the training delivered by a 1500-m runner and the physiological and performance change during a 2-y period. A male international 1500-m runner (personal best 3:38.9 min:s, age 26 y, height 1.86 m, body mass 76 kg) completed 6 laboratory tests and 14 monitored training sessions, during 2 training years. Training distribution and volume was ascertained from training diary and spot-check monitoring of heart rate and accelerometry measurements. Testing and training information were discussed with coach and athlete from which training changes were made. In the first training year, low-intensity training was found to be performed above the prescribed level, which was adjusted with training and coach support in y 2 (training zone < 80% of vVO2max, y 1 = 20%; y 2 = 55%). "Tempo" training was also performed at an excessively high intensity (Δ [blood lactate] 5-25 min of tempo run, y 1 = Δ6.7 mM, y 2 = Δ2.5 mM). From y 1 to 2, there was a concomitant increase in the proportion of training in the high-intensity zone of 100 to 130% vVO2max from 7 to 10%. Values for VO2max increased from 72 to 79 mL · kg-1 · min, economy improved from 210 to 206 mL · kg-1 · min, and 1500-m performance time improved from 3:38.9 to 3:32.4 min:s from the beginning of y 1 to the end of y 2. This case shows a modification in training methodology that was coincident with a greater improvement in physiological capability and furtherance in performance improvement.