Detalhe da pesquisa
1.
A phase 2, open-label, randomized, multiple-dose study evaluating Inarigivir in treatment-naïve patients with chronic hepatitis B.
Liver Int
; 43(1): 77-89, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36300646
2.
SB 9200, a novel agonist of innate immunity, shows potent antiviral activity against resistant HCV variants.
J Med Virol
; 89(9): 1620-1628, 2017 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28303593
3.
Metabolism, pharmacokinetics, tissue distribution, and stability studies of the prodrug analog of an anti-hepatitis B virus dinucleoside phosphorothioate.
Drug Metab Dispos
; 40(5): 970-81, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22328581
4.
Ensemble QSAR: a QSAR method based on conformational ensembles and metric descriptors.
J Comput Chem
; 32(10): 2204-18, 2011 Jul 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-21509786
5.
Diversity-oriented, one-pot, multi-component synthesis of substituted uracil derivatives.
Mol Divers
; 15(1): 263-7, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-20725781
6.
Orally bioavailable anti-HBV dinucleotide acyloxyalkyl prodrugs.
Bioorg Med Chem Lett
; 20(5): 1783-6, 2010 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20117930
7.
NOD2/RIG-I Activating Inarigivir Adjuvant Enhances the Efficacy of BCG Vaccine Against Tuberculosis in Mice.
Front Immunol
; 11: 592333, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33365029
8.
Nucleobase Protection of Deoxyribo- and Ribonucleosides.
Curr Protoc Nucleic Acid Chem
; 69: 2.1.1-2.1.40, 2017 06 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-28628209
9.
Antiviral Efficacy and Host Immune Response Induction during Sequential Treatment with SB 9200 Followed by Entecavir in Woodchucks.
PLoS One
; 12(1): e0169631, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28056062
10.
Nucleotide analogs as novel anti-hepatitis B virus agents.
Curr Opin Pharmacol
; 5(5): 520-8, 2005 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-16087397
11.
In silico optimization of pharmacokinetic properties and receptor binding affinity simultaneously: a 'parallel progression approach to drug design' applied to ß-blockers.
J Biomol Struct Dyn
; 34(2): 384-98, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-25854164
12.
Antiviral Efficacy and Host Innate Immunity Associated with SB 9200 Treatment in the Woodchuck Model of Chronic Hepatitis B.
PLoS One
; 11(8): e0161313, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27552102
13.
RAPID FUNCTIONALIZATION AND LOADING OF SOLID SUPPORTS.
Org Prep Proced Int
; 37(3): 205-212, 2005 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-16604159
14.
Microwave-assisted functionalization of solid supports for rapid loading of nucleosides.
Curr Protoc Nucleic Acid Chem
; Chapter 3: Unit3.13, 2006 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18428955
15.
Anti-HBV nucleotide prodrug analogs: synthesis, bioreversibility, and cytotoxicity studies.
Bioorg Med Chem Lett
; 16(6): 1491-4, 2006 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16387496
16.
Phosphorothioate di- and trinucleotides as a novel class of anti-hepatitis B virus agents.
Antimicrob Agents Chemother
; 48(6): 2199-205, 2004 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-15155222
17.
Anti-hepatitis B virus activity of ORI-9020, a novel phosphorothioate dinucleotide, in a transgenic mouse model.
Antimicrob Agents Chemother
; 48(6): 2318-20, 2004 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-15155244