Detalhe da pesquisa
1.
Decay of an active GPCR: Conformational dynamics govern agonist rebinding and persistence of an active, yet empty, receptor state.
Proc Natl Acad Sci U S A
; 113(42): 11961-11966, 2016 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-27702898
2.
PF-07059013: A non-covalent hemoglobin modulator favorably impacts disease state in a mouse model of sickle cell disease.
Am J Hematol
; 96(8): E272-E275, 2021 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33891711
3.
Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein.
Proc Natl Acad Sci U S A
; 110(52): E5088-97, 2013 Dec 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-24309376
4.
Development and characterization of pepducins as Gs-biased allosteric agonists.
J Biol Chem
; 289(52): 35668-84, 2014 Dec 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25395624
5.
Inter-domain communication of human cystathionine ß-synthase: structural basis of S-adenosyl-L-methionine activation.
J Biol Chem
; 289(52): 36018-30, 2014 Dec 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25336647
6.
Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells.
Proc Natl Acad Sci U S A
; 107(51): 22255-9, 2010 Dec 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-21139054
7.
Snapshots of actin and tubulin folding inside the TRiC chaperonin.
Nat Struct Mol Biol
; 29(5): 420-429, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35449234
8.
Direct interaction between an allosteric agonist pepducin and the chemokine receptor CXCR4.
J Am Chem Soc
; 133(40): 15878-81, 2011 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-21905700
9.
PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease.
J Med Chem
; 64(1): 326-342, 2021 01 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33356244
10.
Crystal structure of the SH3 domain of betaPIX in complex with a high affinity peptide from PAK2.
J Mol Biol
; 358(2): 509-22, 2006 Apr 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-16527308
11.
Assessing structural elements that influence Schiff base stability: mutants E113Q and D190N destabilize rhodopsin through different mechanisms.
Vision Res
; 43(28): 2991-3002, 2003 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-14611935
12.
G protein-coupled receptor modulation with pepducins: moving closer to the clinic.
Ann N Y Acad Sci
; 1226: 34-49, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21615752
13.
A novel interaction between atrophin-interacting protein 4 and beta-p21-activated kinase-interactive exchange factor is mediated by an SH3 domain.
J Biol Chem
; 282(39): 28893-28903, 2007 Sep 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-17652093
14.
Rhodopsin activation exposes a key hydrophobic binding site for the transducin alpha-subunit C terminus.
J Biol Chem
; 279(28): 29767-73, 2004 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-15070895
15.
Role of the retinal hydrogen bond network in rhodopsin Schiff base stability and hydrolysis.
J Biol Chem
; 279(53): 55886-94, 2004 Dec 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-15475355
16.
Stability of dark state rhodopsin is mediated by a conserved ion pair in intradiscal loop E-2.
J Biol Chem
; 278(19): 16982-91, 2003 May 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-12547830