Loading cinnamon oil into pH-sensitive chitosan grafted mesoporous silica nanoparticles via supercritical carbon dioxide.

Stimulus-responsive mesoporous silica nanoparticles (MSNs) have displayed great potentiality for controlled-release and targeted drug delivery. In the current work, a supercritical fluid method was utilized to successfully prepare cinnamon oil loaded into chitosan grafted MSNs (CO@CS-MSNs). The influencing factors of drug loads, such as pressure, temperature, impregnation time and depressure time, were investigated. The structure of CO@CS-MSNs was demonstrated with Fourier-transform infrared (FT-IR) spectroscopy, transmission electron microscope (TEM), scanning electron microscopy (SEM), thermogravimetry (TG) as well as X-ray diffraction (XRD). The drug release assays in vitro at various pH conditions displayed that CO@CS-MSNs had an excellent pH-responsive release behavior, which confirmed that CO was loaded successfully into the CO@CS-MSNs. The findings indicated that the supercritical fluid approach is a non-destructive and efficient approach for stimulus-responsive MSNs, which is expected to further expand its application range.

Permanent Antimicrobial Poly(vinylidene fluoride) Prepared by Chemical Bonding with Poly(hexamethylene guanidine).

Biofouling is one of the major obstacles in the application of poly(vinylidene fluoride) (PVDF) membrane in water and wastewater treatment. Developing antimicrobial PVDF could kill the attached microbe in the initial stage, thus theoretically inhibiting the formation of biofilm and delaying the occurrence of biofouling. However, the leaching of the antimicrobial component and deterioration of antimicrobial properties remain a concern. In this work, an antimicrobial PVDF (PVDF-g-AGE-PHMG) was developed by chemical bonding PVDF with poly(hexamethylene guanidine hydrochloride) (PHMG). The obtained PVDF-g-AGE-PHMG was blended with pristine PVDF to prepare an antimicrobial PVDF membrane. The results of Fourier transform infrared spectroscopy (FT-IR) and X-ray photoelectron spectroscopy (XPS) confirmed that PHMG was successfully grafted into the PVDF membrane. The morphologies, membrane porosity, water contact angles, antimicrobial properties, mechanical properties, and thermostability of the as-prepared membranes were investigated. When the content of PVDF-g-AGE-PHMG reached 10.0 wt %, the inhibition rates of both antimicrobial PVDF membrane against Escherichia coli and Staphylococcus aureus were above 99.99%. Due to the increased hydrophilicity, excellent antimicrobial activity, nonleaching of antimicrobial component, good mechanical properties, and thermostability, the as-prepared PVDF membrane has promising applications in the field of water treatment.