Relationships Between Clinico-Epidemiological Patterns of Invasive Meningococcal Infections and Complement Deficiencies in French South Pacific Islands (New Caledonia).

PURPOSE: Invasive Meningococcal Disease (IMD) is three fold more common in New Caledonia (NC) than in metropolitan France and many IMD cases (35.7%) are due to Y and W135 serogroups. The purpose of our study was to identify IMD risk factors in NC. METHODS: A retrospective study of all IMD cases that occurred in NC between 2005 and 2011 was conducted. Socio-environmental, clinical and biological data were collected. A search for immune deficiency was proposed to all cases. IMD presentation and outcome were compared according to meningoccal serogroups and the complement deficiency status (C-deficiency). RESULTS: Sixty-six sporadic IMD cases (29 B serogroup, 20 Y or W135, 6 C, 1 A, 10 unknown) occurred in 64 patients often <24 years-old and of Melanesian origin. Five patients died (7.8%). No socio-environmental risk factors were identified. No asplenia, HIV infection or immunoglobulin deficiencies were found. Two patients had diabetes and 28 of 53 (52.8%) patients had C-deficiency including 20 (71.4%) cases of late complement component deficiency. Patients with C-deficiency were mainly Melanesian (92.8%) originating from the Loyalty Islands (62.1%). They were mostly infected with Y/W135 (42.9%) or B serogroups (32.1%). They often developed later and more severe disease than patients without C-deficiency (need for intensive cares in 60% versus 28.0% of cases, p = 0.01). CONCLUSIONS: A high prevalence of C-deficiency in the Melanesian population may explain epidemiological and clinical features of IMD in NC. Our results imply an adaptation of meningococcal vaccine strategies in NC.

Environmental Life Cycle Assessment of a Novel Hemp-Based Building Material.

The global construction sector contributes a significant share of total greenhouse gas (GHG) emissions. In Australia, infrastructure activity alone generates 18% of the GHG emissions. The use of low-embodied carbon building materials is crucial to decarbonise the construction sector and fulfil national and international climate goals. Industrial hemp (Cannabis sativa L.) is a promising feedstock for low-carbon construction materials because of its carbon sequestration capacity, fast-growing cycles, and technical functionality comparable to traditional materials. This study utilised the life cycle assessment (LCA) guideline ISO 14040:2006 to estimate the carbon footprint (CF) of hemp-based building materials in Western Australia capturing region-specific variations in terms of inputs, soil, productivity, and energy mix. The functional unit was 1 m2 of a hemp-based board, and the system boundary was cradle-to-gate, i.e., pre-farm, on-farm, and post-farm activities. The CF of 1 m2 of hemp-based board was estimated to be -2.302 kg CO2 eq. Electricity from the public grid for bio-based binder production during the post-farm stage was the main contributor to total CO2 eq emissions (26%), followed by urea production (14%) during the pre-farm stage. Overall, the use of electricity from the public grid during the post-farm stage accounted for 45% of total emissions. Sensitivity analysis showed that the CF of hemp-based boards was highly sensitive to the source of energy; i.e., total replacement of the public grid by solar power decreased the CF by 164% (-2.30 to -6.07 kg CO2 eq). The results suggested that hemp-based boards exhibit lower embodied GHG emissions compared to traditional materials, such as gypsum plasterboards.

Environmental impact evaluation of landfill mining of legacy waste with on-site sorting using life cycle assessment.

The present research is aimed at assessing the environmental impacts of landfill mining of soil-like material with on-site sorting for land application using life cycle assessment. The scenario is compared with no-landfill mining (base scenario) and future scenario (including material recycling and incineration). Soil-like material is processed using windrow composting. The impact assessment was performed using the EASETECH™ software tool. ReCipE 2016 midpoint world impact method with eight impact categories was used for assessing the environmental profiles. The functional unit of the assessment was 1 t of recovered waste in India. Overall, the results showed that excavation of landfilled waste with on-site recovery of soil and land application of soil resulted in higher environmental benefits compared to no mining condition in global warming potential (GWP), freshwater eutrophication (FEW), human toxicity (HT), and fossil depletion (FD), while higher impacts were observed in terrestrial acidification (TA), terrestrial ecotoxicity (TE), marine eutrophication (ME), and photochemical oxidation (PCO). After composting, land application of recovered soil contributed to environmental offsets in GWP, HT, and FEW while contributing to TE emissions. Emissions associated with excavation and on-site sorting contributed 55.1% to freshwater toxicity, 25.5% to human toxicity, 16.2% to climate change, and 10.8% to terrestrial acidification. The choice of energy, transportation, and fuel for waste activities affected the performance of alternative scenarios in GWP. Application of recovered metals in the manufacturing process, incineration of plastic, and textile components improved the environmental performance. The outcomes of this research will equip regulatory bodies in the development of guidelines and frameworks on material and energy recovery from the waste components mined from legacy waste.

WS2 monolayer-based light-emitting devices in a vertical p-n architecture.

2D semiconductors represent an exciting new material class with great potential for optoelectronic devices. In particular, WS2 monolayers are promising candidates for light-emitting devices (LEDs) due to their direct band gap with efficient recombination in the red spectral range. Here, we present a novel LED architecture by embedding exfoliated WS2 monolayer flakes into a vertical p-n layout using organic p- and inorganic n-supporting layers. Laser lithography was applied to define the current path perpendicular to the WS2 flake. The devices exhibit rectifying behavior and emit room temperature electroluminescence with luminance up to 50 cd m-2 in the red spectral range.