RESUMO
OBJECTIVES: This study was designed to assess the prevalence of major cardiovascular risk factors in familial premature coronary artery disease (P-CAD), affecting two or more siblings within one sibship. BACKGROUND: Premature CAD has a genetic component. It remains to be established whether familial P-CAD is due to genes acting independently from major cardiovascular risk factors. METHODS: We recruited 213 P-CAD survivors from 103 sibships diagnosed before age Assuntos
Doenças Cardiovasculares
, Doença das Coronárias/genética
, Adulto
, Idade de Início
, Feminino
, Humanos
, Hipercolesterolemia/epidemiologia
, Hipertensão/epidemiologia
, Masculino
, Pessoa de Meia-Idade
, Infarto do Miocárdio/genética
, Obesidade/epidemiologia
, Linhagem
, Prevalência
, Fatores de Risco
, Fumar/epidemiologia