The effects of Zoo Lights on animal welfare: A case study of great Indian hornbills at Denver Zoo.

Popular evening events, such as Zoo Lights, increase the exposure of animals in managed care to stressors such as artificial light and noise, which may alter their behavior and negatively affect animal well-being. The pair of great Indian hornbills (Buceros bicornis) at Denver Zoo provided an opportunity to study the impacts of these stressors because their exhibit was open every evening during Zoo Lights 2017. We expected the hornbills to display increased aggressive behaviors during Zoo Lights due to more exposure to stressors compared to the periods before and after the holiday event. Alternatively, if behavioral changes were associated with hornbills' breeding season which runs from December-March, we expected the hornbills to engage in more affiliative behaviors, and to increase conspecific and nest proximity, during and after Zoo Lights compared to before it due to the onset and progression of the breeding season. The hornbills did not engage in significantly more aggressive behavior during Zoo Lights than before or after it. By contrast, the hornbills engaged in significantly more affiliative behaviors and increased conspecific proximity during and after Zoo Lights compared to before the event. These results are consistent with the timing of the hornbills' breeding season and not with the increased exposure to stressors during Zoo Lights. This case study provides an early step in assessing the impact of Zoo Lights on animals whose exhibits are part of these holiday events. Studies like this will help inform best practices for Zoo Lights events such that they are positive experiences for the zoo, visitors, and animals.

Limited Longitudinal Evidence Suggests That Socioeconomic Position May Influence Periodontal Diseases Over the Course of Life.

ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Socioeconomic position during life and periodontitis in adulthood: a systematic review. Schuch HS, Peres KG, Singh A, Peres MA, Do LG. Community Dent Oral Epidemiol 2017; 45(3):201-8. SOURCE OF FUNDING: Brazilian Government Agency-CAPES: Coordination for the Improvement of Higher Education Personnel for the PhD Scholarship (HSS-Process 13374-13-1) TYPE OF STUDY/DESIGN: Systematic review.

Associations of Neighborhood Safety and Neighborhood Support with Overweight and Obesity in US Children and Adolescents.

OBJECTIVES: To examine the association of neighborhood safety and support with overweight and obesity and whether these associations vary with age, sex, and race/ethnicity among children and adolescents. DESIGN: Cross-sectional. SETTING: United States. MAIN OUTCOME MEASURES: Childhood overweight and obesity. METHODS: We used data from the 2011-12 National Survey of Children's Health, a representative sample of US children and adolescents, for the analyses (N=40,730). Using the age-sex adjusted growth chart, parent self-reported weight and height data were used to classify participants as overweight (those with body mass index [BMI] percentile [%] at or above the 85th%) and obese (those with BMI% at or above the 95th%). We used log-binomial regression to quantify the association of neighborhood safety and support with overweight and obesity among children and adolescents before and after adjusting for selected characteristics including physical activity and amount of time spent in sedentary activities. RESULTS: Children and adolescents living in non-supportive neighborhoods had a 21% (95%CI: 1.10-1.33) higher probability of being obese than their peers living in supportive neighborhoods after controlling for age, sex, race/ethnicity, parent's education, poverty, asthma, physical activity and sedentary activities. Similarly, the probabilities of obesity associated with neighborhood safety and support were 1.30 (95%CI:1.08-156) and 1.18 (95%CI:1.01-1.38), respectively. However, these probabilities vary with race/ethnicity with higher probability being observed among non-Hispanic Whites and Hispanics for overweight and non-Hispanic Whites for obesity. CONCLUSIONS: Living in unsafe and non-supportive neighborhoods may be associated with overweight and obesity among US children and adolescents. Longitudinal studies, accounting for race/ethnicity, are needed to examine the importance of social context where children and adolescents live.

Indirect modulation of the endocannabinoid system by specific fractions of nutmeg total extract.

CONTEXT: Nutmeg [Myristica fragrans Houtt. (Myristicaceae)] has a long-standing reputation of psychoactivity. Anecdotal reports of nutmeg use as a cheap marijuana substitute, coupled to previous studies reporting a cannabimimetic-like action, suggest that nutmeg may interact with the endocannabinoid system. OBJECTIVE: The study evaluates nutmeg fractions for binding capacity with various CNS receptors and their potential interaction with the endocannabinoid system. MATERIALS AND METHODS: Dichloromethane (DF) and ethyl acetate (EF) fractions were prepared from the methanol extract of powdered whole nutmeg. The HPLC-profiled fractions were assayed by the NIMH Psychoactive Drug Screening Program (PDSP) in a panel of CNS targets at a 10 µg/mL concentration. The fractions were also screened for fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) inhibition, initially at a concentration of 500 µg/mL, then by concentration-dependent inhibition studies. RESULTS: None of the tested fractions showed significant binding to CNS receptors included in the PDSP panel. However, both fractions exerted significant inhibition of the FAAH and MAGL enzymes. The DF fraction inhibited FAAH and MAGL enzymes at IC50 values of 21.06 ± 3.16 and 15.34 ± 1.61 µg/mL, respectively. Similarly, the EF fraction demonstrated FAAH and MAGL inhibition with IC50 values of 15.42 ± 3.09 and 11.37 ± 6.15 µg/mL, respectively. DISCUSSION AND CONCLUSION: The study provides the first piece of evidence that nutmeg interacts with the endocannabinoid system via inhibition of the endocannabinoid catabolizing enzymes. This mechanism provides insight into reported cannabis-like action as well as expands the potential therapeutic utility of nutmeg.

Role of innate T cells in necrotizing enterocolitis.

Necrotizing enterocolitis (NEC) is a destructive gastrointestinal disease primarily affecting preterm babies. Despite advancements in neonatal care, NEC remains a significant cause of morbidity and mortality in neonatal intensive care units worldwide and the etiology of NEC is still unclear. Risk factors for NEC include prematurity, very low birth weight, feeding with formula, intestinal dysbiosis and bacterial infection. A review of the literature would suggest that supplementation of prebiotics and probiotics prevents NEC by altering the immune responses. Innate T cells, a highly conserved subpopulation of T cells that responds quickly to stimulation, develops differently from conventional T cells in neonates. This review aims to provide a succinct overview of innate T cells in neonates, encompassing their phenotypic characteristics, functional roles, likely involvement in the pathogenesis of NEC, and potential therapeutic implications.

Social Dynamics of a Newly Integrated Bachelor Group of Asian Elephants (Elephas maximus): Welfare implications.

Male associations are a typical component of elephant society, allowing bulls to practice appropriate social behavior. To improve zoo elephant welfare, it is important to provide bulls with social opportunities. In fall 2018, Denver Zoo added two bull Asian elephants to its existing all-male group of three bulls, offering the opportunity to conduct a systematic behavioral study of the integration of the new bulls into the resident group. We recorded aggressive and affiliative behaviors before, during, and after the introduction of the new males. The proportion of aggressive behavior was significantly higher during the five-month introduction period compared to before their introduction. By the end of the study period, the elephants engaged in significantly more affiliative behavior and less aggressive behavior than during the introduction period, suggesting they had formed a new stable social dynamic. These results suggest group compatibility and positive elephant welfare resulting from housing male elephants together and can be used to inform management plans for bull elephants that prioritize their welfare.

Nighttime behavior and the length of social relationships in male Asian elephants.

To evaluate elephant welfare, it is important to understand their use of time both during day and night. The length of social relationships can influence how much time they spend in different activities. We assessed daytime and nighttime activity budgets of male Asian elephants at Denver Zoo and examined how length of relationships influenced nighttime behavior. Using scan sampling we investigated activity budget and proximity to a conspecific, and used General Estimating Equations to compare them across day and night and across new and established dyads at night. During daytime, elephants spent significantly more time exhibiting affiliative and agonistic behaviors, and in proximity to a conspecific, and less time resting, compared to night. Overnight, the odds of resting were significantly lower in new social dyads compared to established dyads, and new dyads spent more time exhibiting agonistic behavior and in proximity to a conspecific compared to established dyads. Our study suggests that male elephants at Denver Zoo have developed strong relationships and highlights the importance of systematically observing elephants overnight so that managers make decisions that improve animal welfare.

Vitreoretinal disease: a critical review on current technological perspectives and innovative drug-delivery strategies.

Aim: To review the state of the art aspects and contemporary innovative drug delivery strategies, for the treatment of vitreoretinal diseases, their mechanism of action through ocular routes and their future perspectives. Materials & methods: Scientific databases such as PubMed, Science Direct, Google scholar were used to obtain 156 papers for review. The keywords searched were vitreoretinal diseases; ocular barriers; intravitreal injections; nanotechnology; biopharmaceuticals. Results & conclusion: The review explored the various routes which can be used to facilitate drug delivery adopting novel strategies, the pharmacokinetic aspects of novel drug-delivery strategies in treating posterior segment eye diseases and current research. Therefore, this review drives focus into the same and underlines their implications to the healthcare sector in making necessary interventions.

Eye diseases that affect the major part of the eye can create eyesight loss in patients. Even though medicines are now available, there is a need to drive the existing techniques further. These can be done by the use of small sized particles in the treatment, which are easy to reach the site wherever healing is required. Natural medicines and treatment can also benefit people. In this paper, we discuss treatment approaches on these factors and their importance in curing people with eye diseases.

Saxophone penis - An intriguing manifestation of gastrointestinal metastasis.

Genital elephantiasis is associated with sexually transmitted infections such as lymphogranuloma venereum. Here we present an unusual and rare non-venereal cause of Saxophone penis.

Bullying and lifetime asthma among children and adolescents in the United States.

PURPOSE: To examine the association of experiencing bullying within the past year with the prevalence of lifetime childhood asthma in U.S. children and adolescents; and whether this association varies with sex of the child and selected socioeconomic indicators. METHODS: We performed secondary analyses using data from the 2018 National Survey of Children's Health participants aged 6 to 17 years (n=19,766). We used log-binomial regression to examine the association between bullying and lifetime childhood asthma before and after controlling for selected covariates. We also tested interactions of bullying with sex and selected socioeconomic indicators. RESULTS: Children who experience bullying have a significantly greater probability of having asthma in adjusted analyses. The probability of childhood asthma increased with the frequency of bullying with prevalence ratios starting at 1.28 (95%CI:1.06, 1.55) for children bullied one to two times per year to 1.59 (95%:1.22, 2.09) for those being bullied at least four times per month. This association did not differ with sex of the child or selected socioeconomic indicators. CONCLUSIONS: We found that children who experienced bullying had a greater probability of having asthma relative to those who never experienced bullying. These findings highlight the impact of psychosocial stressors such as bullying as a nontraditional trigger in children with asthma.

Pancreatic Neuroendocrine Tumors: The Effect of Facility Type on Patient Survival.

OBJECTIVES: During the last decades, significant progress has been made in the management of patients with pancreatic neuroendocrine tumors (pNETs). It is unclear how the type of the treating health care facility alters patient outcomes. METHODS: Data from pNETs reported to the National Cancer Database between 2004 and 2016 were examined. Types of institutions were as follows: academic/research cancer program (ARP), comprehensive community cancer program (CCCP), integrated network cancer program (INCP), and community cancer program (CCP). RESULTS: A total of 17,887 patients with pNETs were analyzed. Treatment at ARPs was significantly associated with receipt of surgery (ARP, 61.9%; CCCP, 45.6%; CCP, 29.9%; INCP, 55.5%; P < 0.001), both for patients with very early tumors ≤2 cm (ARP, 74.7%; CCCP, 66.5%; CCP, 52.4%; INCP, 71.6%; P < 0.001) and for patients with liver metastases (ARP, 21.3%; CCCP, 10.6%; CCP, 5%; INCP, 16.8%; P < 0.001). Treatment at ARPs was associated with improved survival (median overall survival: ARP, 91 mo; CCCP, 47 mo; CCP, 24.5 mo; INCP, 72 mo; P < 0.001). CONCLUSIONS: Treatment of pNETs at academic/research programs is associated with more frequent resections and best survival outcomes. This survival benefit exists for early and late stages and after adjusting for known cofactors.

Evaluating the change in patterns of traumatic injury in the setting of pandemic and social distancing restrictions: An analysis of a level 1 trauma center.

BACKGROUND: Social distancing measures and quarantine during the COVID-19 pandemic have led to reported changes in traumatic injury patterns. We set to examine the effects of these restrictive guidelines in our trauma center. METHODS: This is a retrospective chart review of all patients evaluated for traumatic injuries at a Level 1 trauma center during two time periods: March-June 2020 (COVID) and March-June 2019 (Pre-COVID). RESULTS: Overall trauma volume did not differ significantly between the two time periods. Changes seen during COVID included increases in penetrating injuries (12.5% vs 6.7%, p < 0.001), particularly those due to firearms (7.5% vs 3.7%, p < 0.001). Hospital length of stay, intensive care unit length of stay, and days on the ventilator remained consistent between the two groups. Trends toward increased injuries in the home and non-accidental trauma were not statistically significant. CONCLUSION: Traumatic injury patterns have changed as a result of social distancing in both the adult and pediatric trauma populations. Analyzing the effects of social distancing on trauma can lead to a better development of preventive strategies.

Racial/ethnic disparities on self-reported hypertension in New York City: examining disparities among Hispanic subgroups.

OBJECTIVES: To investigate differences in self-reported hypertension among Hispanic subgroups as they compare to Asian, non-Hispanic Black and non-Hispanic White groups; and whether these differences depend on nativity status in the New York City Community Health Survey 2006-2008. DESIGN: Cross-sectional. SETTING: New York City. MAIN OUTCOME MEASURE: Self-reported hypertension. METHODS: Log-binomial regression was used to estimate the strength of the association between race/ethnicity and self-reported hypertension before and after adjusting for selected covariates. RESULTS: In adjusted analyses, Puerto Ricans, Dominicans and Blacks had 17%, 28% and 34% greater probability of reporting hypertension than Whites. The association between race/ethnicity and self-reported hypertension appears to vary with nativity status/length of stay in the United States. (P=.08). CONCLUSIONS: These findings underscore the need to investigate the prevalence of hypertension among subgroups of the Hispanic population. This issue is also relevant to Asians and Blacks, who are very heterogeneous populations regarding subgroups and nativity status.

Prevalence of depression amongst the Elderly population in old age homes of Mangalore city.

CONTEXT: Depression is a silent killer. The people living in the old age homes (OAHs) appear to be overtly neglected by the community and depression is easily overlooked in such individuals especially in elderly people with comorbidities. Its early detection and treatment are imperative to improve quality of life. AIM: To find the prevalence of depression and the socio-demographic factors associated with depression among the elderly of OAHs. MATERIALS AND METHODS: A Cross-sectional study in geriatric population of OAHs around Mangalore city was conducted over a duration of 5 months. About 142 elderly above the age of 60 years participated in the study. The study tools used were Geriatric Depression Scale-15 (GDS-15), Activities of Daily Living Scale (Katz index) and socio-demographic questionnaire. STATISTICAL ANALYSIS USED: The results were expressed in percentages and proportions. Univariate logistic regression analysis was done to find out the associated sociodemographic factors. Means and standard deviation of the GDS-15 and KATZ index scores were calculated and correlation was assessed between both the scores. RESULTS: The overall prevalence of depression was 47.8% by using the GDS. The GDS score and Katz score were found to have a significant negative correlation. (r = -0.245 P = 0.003). Less social interaction amongst the peers was found to be associated with depression. CONCLUSIONS: The prevalence of depression in this study population was moderately high. Spending time with other residents was protective and functionally able people were less likely to have depression.

Stimuli-Responsive Polymeric Nanosystem for Colon Specific Drug Delivery.

An ideal colon specific drug delivery system needs to perform multiple functions like greater bio availability, less toxicity and higher therapeutic efficacy, all of which require high degree of smartness. This article focuses on the overview of the stimuli-responsive polymers and various nanodrug delivery systems which have found applications in colon specific delivery of drugs as this system provide a link between therapeutic need and drug delivery. These polymers exhibit a non-linear response to a small stimulus leading to a macroscopic alteration in their structure/properties. Stimuli responsive polymers display a significant physio chemical change in response to small changes in their environment (temperature, pH, light etc.). Colonic drug delivery has gained increased importance in treating diseases like Crohn's disease, ulcerative colitis, colon cancer etc. The expansion in the development of polymers based system with greater flexibility, versatility and unexplored potential enables new opportunities for them in uplifting bio medicine. Applying the concepts of smartness in the context of clinically relevant therapeutic and diagnostic systems, it can prelude in a new era of 'smart' therapeutics that can improve the health care fields. In particular, due to its high sensitivity to the stimuli, this system has been identified as a sensible platform for releasing drug at suitable site and at appropriate time.

Sustained improvement in cognitive and emotional status of apneic patients after prolonged treatment with positive airway pressure.

BACKGROUND: Obstructive sleep apnea-hypopnea syndrome (OSAH) is associated with impairment of cognitive functions and disturbances in emotional status. The aim of this study was to objectively evaluate the benefits of prolonged and sustained treatment for OSAH at two sleep centers serving rural community hospitals. METHODS: Fifty-six patients diagnosed with OSAH syndrome underwent Cognistat, Beck Depression Inventory (BDI) and Millon Behavioral Medicine Diagnostic Inventory (MBMD) testing before initiation of treatment. Repeated testing after six months of therapy with positive airway pressure (PAP) was performed. RESULTS: Significant improvements were noted in the BDI scale scores and a reduction in the MBMD scores reflected initial abnormal clinical personal symptoms that improved with treatment. MBMD analysis showed subjects with fewer symptoms of anxiety post baseline, which were sustained at 6 months post-treatment. Memory function improved as reflected by performance on the Cognistat. Women were observed to have a higher post-treatment BDI and younger patients appeared to have more shifts for improvement than older subjects in depressive symptomatology. CONCLUSIONS: These results indicate that prolonged and sustained PAP therapy is effective in restoring some of the deficiencies in patients with OSAH, particularly in terms of memory, depression, anxiety and increased psychological pathology.

The health of homeless children revisited.

To the extent that representative data are available for specific health conditions (eg, under-immunization, asthma prevalence), the authors' data suggest that the gap between the health status of homeless children and housed children in minority, low-income families is narrowing. Studies of the health status of homeless children allow a window into the health status of medically underserved children whose needs may not be readily documented because of their lack of access to the health care system. Although prevalence rates of most of the health conditions discussed in this article exceeded national norms, they were generally consistent with rates characteristic of health disparities based on race-ethnicity and income. It must be emphasized that in most instances, children were seen for their first pediatric visit within weeks of entering the homeless shelter system. The health conditions identified were often present before the child and family became homeless. The high prevalence of asthma among homeless children should therefore be a matter of concern to health providers and payors, because the authors' data strongly suggest that this is not confined to children in homeless shelters as a special population. Similarly, childhood obesity predates homelessness (or at least the episode of homelessness during which health care was provided) and as such the authors' data may indicate the extent of this problem more generally among medically underserved children in the communities of origin. These conditions seem to be exacerbated by the specific conditions associated with homeless shelter life. Asthma care, assuming it was previously available, is disrupted when housing is lost, and shelter conditions may have multiple asthma triggers. Nutrition often suffers as a result of inadequate access to nutritious food and cooking facilities in shelters, as indicated by the high rate of iron-deficiency anemia among very young children. It is clear that homeless children in shelters require enhanced access to primary and specialist care. Shelter placement necessarily disrupts prior health care relationships (if any), while simultaneously placing additional stress on the child's physical and emotional well being. A medical home model is strongly recommended to allow for continuous, culturally competent care. Developmental and mental health problems are also more prevalent among homeless children. These conditions may jeopardize life successes. The overcrowding associated with homeless shelters and the housing conditions that frequently precede episodes of homelessness are associated with the higher prevalence of otitis media found among young children. This in turn is associated with developmental delay. Also contributing to the developmental risk associated with homelessness is exposure to DV, which is also frequently an antecedent of homelessness. Developmental surveillance for young, homeless children, monitoring of school attendance and academic performance, and assessment of mental status for homeless adolescents are recommended to facilitate early identification of problems and delivery of necessary interventions. For young children, providers of health care to the homeless should be well networked into the Early Intervention and Preschool Special Education programs in their locality. Given the multiplicity of needs for homeless families, which of course includes help finding affordable housing, health care providers serving this population should also develop linkages with community agencies, including those that can help parents develop the skills necessary for economic self-sufficiency and long-term ability to sustain independent housing.

Suppression of ovulation in Nile Hippopotamus (Hippopotamus amphibious) using melengestrol acetate-treated feed or high dose Depo-Provera injection.

Analysis of fecal progestogen profiles during Depo-Provera injection (1,200 mg; DEPO, Pfizer Inc., New York, NY), melengestrol acetate (MGA) in feed (2 or 3 mg/head/day), and a combination treatment (DEPO+MGA) are presented for nine captive female Nile hippos housed at Disney's Animal Kingdom in Florida. All tested treatments reduced fecal progestogen elevations successfully to durations consistent with prevention of ovulation for a portion of the treatment period. Percentage of treatment months with suppression of luteal phases indicative of ovulation was maximal for high-dose MGA (91.7+/-13.9%) and DEPO+MGA (91.7+/-20.4%), followed by DEPO injection alone (69.2+/-13.9%) and low-dose MGA (57.6+/-33.2%). Both 1,200 mg DEPO and low-dose MGA (2.0 mg/day) treatments were insufficient to prevent an apparent seasonal breakthrough of ovarian activity from June-August 2002. Although luteal phases were observed, no females conceived during those months. Overall, in 133.5 treatment months with females housed with an adult male, one female conceived during the transition period between treatments. After cessation of contraceptive treatment, average latency to first normal ovarian cycle was 80.6+/-19.5 days (range = 22-179 days). Up to 12 months post-treatment, however, successive cycles were often irregular with evidence of short periods of anovulation and shortened luteal phases in all females monitored. In conclusion, high dose and combination treatments were most successful in preventing progestogen increases indicative of ovulation in hippos. Zoo Biol 26:259-274, 2007. (c) 2007 Wiley-Liss, Inc.