Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

The Small Molecule BC-2059 Inhibits Wingless/Integrated (Wnt)-Dependent Gene Transcription in Cancer through Disruption of the Transducin ß-Like 1-ß-Catenin Protein Complex.

Soldi, Raffaella; Halder, Tithi Ghosh; Sampson, Samuel; Vankayalapati, Hariprasad; Weston, Alexis; Thode, Trason; Bhalla, Kapil N; Ng, Serina; Rodriguez Del Villar, Ryan; Drenner, Kevin; Kaadige, Mohan R; Horrigan, Stephen K; Batra, Surinder K; Salgia, Ravi; Sharma, Sunil.

J Pharmacol Exp Ther ; 378(2): 77-86, 2021 08.

Artigo em Inglês | MEDLINE | ID: mdl-34006586

2.

Metabolic reprogramming in triple-negative breast cancer through Myc suppression of TXNIP.

Shen, Liangliang; O'Shea, John M; Kaadige, Mohan R; Cunha, Stéphanie; Wilde, Blake R; Cohen, Adam L; Welm, Alana L; Ayer, Donald E.

Proc Natl Acad Sci U S A ; 112(17): 5425-30, 2015 Apr 28.

Artigo em Inglês | MEDLINE | ID: mdl-25870263

3.

A 13-week low glycemic load diet and lifestyle modification program combining low glycemic load protein shakes and targeted nutraceuticals improved weight loss and cardio-metabolic risk factors.

Dahlberg, Clinton J; Ou, Joseph J; Babish, John G; Lamb, Joseph J; Eliason, Sarah; Brabazon, Holly; Gao, Wei; Kaadige, Mohan R; Tripp, Matthew L.

Can J Physiol Pharmacol ; 95(12): 1414-1425, 2017 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-28800398

4.

Synergistic in vitro antioxidant activity and observational clinical trial of F105, a phytochemical formulation including Citrus bergamia, in subjects with moderate cardiometabolic risk factors.

Babish, John G; Dahlberg, Clinton J; Ou, Joseph J; Keller, William J; Gao, Wei; Kaadige, Mohan R; Brabazon, Holly; Lamb, Joseph; Soudah, Hani C; Kou, Xiaolan; Zhang, Zhe; Pacioretty, Linda M; Tripp, Matthew L.

Can J Physiol Pharmacol ; 94(12): 1257-1266, 2016 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-27463949

5.

MondoA senses non-glucose sugars: regulation of thioredoxin-interacting protein (TXNIP) and the hexose transport curb.

Stoltzman, Carrie A; Kaadige, Mohan R; Peterson, Christopher W; Ayer, Donald E.

J Biol Chem ; 286(44): 38027-38034, 2011 Nov 04.

Artigo em Inglês | MEDLINE | ID: mdl-21908621

6.

ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression.

Shi, Xiaobing; Hong, Tao; Walter, Kay L; Ewalt, Mark; Michishita, Eriko; Hung, Tiffany; Carney, Dylan; Peña, Pedro; Lan, Fei; Kaadige, Mohan R; Lacoste, Nicolas; Cayrou, Christelle; Davrazou, Foteini; Saha, Anjanabha; Cairns, Bradley R; Ayer, Donald E; Kutateladze, Tatiana G; Shi, Yang; Côté, Jacques; Chua, Katrin F; Gozani, Or.

Nature ; 442(7098): 96-9, 2006 Jul 06.

Artigo em Inglês | MEDLINE | ID: mdl-16728974

7.

Glutamine-dependent anapleurosis dictates glucose uptake and cell growth by regulating MondoA transcriptional activity.

Kaadige, Mohan R; Looper, Ryan E; Kamalanaadhan, Sadhaasivam; Ayer, Donald E.

Proc Natl Acad Sci U S A ; 106(35): 14878-83, 2009 Sep 01.

Artigo em Inglês | MEDLINE | ID: mdl-19706488

8.

Long-term hepatitis B virus infection of rhesus macaques requires suppression of host immunity.

Biswas, Sreya; Rust, Lauren N; Wettengel, Jochen M; Yusova, Sofiya; Fischer, Miranda; Carson, Julien N; Johnson, Josie; Wei, Lei; Thode, Trason; Kaadige, Mohan R; Sharma, Sunil; Agbaria, Majd; Bimber, Benjamin N; Tu, Thomas; Protzer, Ulrike; Ploss, Alexander; Smedley, Jeremy V; Golomb, Gershon; Sacha, Jonah B; Burwitz, Benjamin J.

Nat Commun ; 13(1): 2995, 2022 05 30.

Artigo em Inglês | MEDLINE | ID: mdl-35637225

9.

Protein synthesis inhibitors stimulate MondoA transcriptional activity by driving an accumulation of glucose 6-phosphate.

Wilde, Blake R; Kaadige, Mohan R; Guillen, Katrin P; Butterfield, Andrew; Welm, Bryan E; Ayer, Donald E.

Cancer Metab ; 8(1): 27, 2020 Dec 04.

Artigo em Inglês | MEDLINE | ID: mdl-33292639

10.

The novel reversible LSD1 inhibitor SP-2577 promotes anti-tumor immunity in SWItch/Sucrose-NonFermentable (SWI/SNF) complex mutated ovarian cancer.

Soldi, Raffaella; Ghosh Halder, Tithi; Weston, Alexis; Thode, Trason; Drenner, Kevin; Lewis, Rhonda; Kaadige, Mohan R; Srivastava, Shreyesi; Daniel Ampanattu, Sherin; Rodriguez Del Villar, Ryan; Lang, Jessica; Vankayalapati, Hariprasad; Weissman, Bernard; Trent, Jeffrey M; Hendricks, William P D; Sharma, Sunil.

PLoS One ; 15(7): e0235705, 2020.

Artigo em Inglês | MEDLINE | ID: mdl-32649682

11.

MondoA-Mlx transcriptional activity is limited by mTOR-MondoA interaction.

Kaadige, Mohan R; Yang, Jingye; Wilde, Blake R; Ayer, Donald E.

Mol Cell Biol ; 35(1): 101-10, 2015 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-25332233

12.

Response of BRAF-mutant melanoma to BRAF inhibition is mediated by a network of transcriptional regulators of glycolysis.

Parmenter, Tiffany J; Kleinschmidt, Margarete; Kinross, Kathryn M; Bond, Simon T; Li, Jason; Kaadige, Mohan R; Rao, Aparna; Sheppard, Karen E; Hugo, Willy; Pupo, Gulietta M; Pearson, Richard B; McGee, Sean L; Long, Georgina V; Scolyer, Richard A; Rizos, Helen; Lo, Roger S; Cullinane, Carleen; Ayer, Donald E; Ribas, Antoni; Johnstone, Ricky W; Hicks, Rodney J; McArthur, Grant A.

Cancer Discov ; 4(4): 423-33, 2014 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-24469106

13.

Coordination of glucose and glutamine utilization by an expanded Myc network.

Kaadige, Mohan R; Elgort, Marc G; Ayer, Donald E.

Transcription ; 1(1): 36-40, 2010.

Artigo em Inglês | MEDLINE | ID: mdl-21327161

14.

Analysis of Opi1p repressor mutants.

Kaadige, Mohan R; Lopes, John M.

Curr Genet ; 49(1): 30-8, 2006 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-16322993

15.

The polybasic region that follows the plant homeodomain zinc finger 1 of Pf1 is necessary and sufficient for specific phosphoinositide binding.

Kaadige, Mohan R; Ayer, Donald E.

J Biol Chem ; 281(39): 28831-6, 2006 Sep 29.

Artigo em Inglês | MEDLINE | ID: mdl-16893883

16.

Opi1p, Ume6p and Sin3p control expression from the promoter of the INO2 regulatory gene via a novel regulatory cascade.

Kaadige, Mohan R; Lopes, John M.

Mol Microbiol ; 48(3): 823-32, 2003 May.

Artigo em Inglês | MEDLINE | ID: mdl-12694624

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