Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

Correction of age-associated defects in dendritic cells enables CD4⁺ T cells to eradicate tumors.

Zhivaki, Dania; Kennedy, Stephanie N; Park, Josh; Boriello, Francesco; Devant, Pascal; Cao, Anh; Bahleda, Kristin M; Murphy, Shane; McCabe, Cristin; Evavold, Charles L; Chapman, Kate L; Zanoni, Ivan; Ashenberg, Orr; Xavier, Ramnik J; Kagan, Jonathan C.

Cell ; 2024 Jun 12.

Artigo em Inglês | MEDLINE | ID: mdl-38870946

2.

Innate immune pattern recognition: a cell biological perspective.

Brubaker, Sky W; Bonham, Kevin S; Zanoni, Ivan; Kagan, Jonathan C.

Annu Rev Immunol ; 33: 257-90, 2015.

Artigo em Inglês | MEDLINE | ID: mdl-25581309

3.

Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway.

Evavold, Charles L; Hafner-Bratkovic, Iva; Devant, Pascal; D'Andrea, Jasmin M; Ngwa, Elsy M; Borsic, Elvira; Doench, John G; LaFleur, Martin W; Sharpe, Arlene H; Thiagarajah, Jay R; Kagan, Jonathan C.

Cell ; 184(17): 4495-4511.e19, 2021 08 19.

Artigo em Inglês | MEDLINE | ID: mdl-34289345

4.

Molecular mechanisms of gasdermin D pore-forming activity.

Devant, Pascal; Kagan, Jonathan C.

Nat Immunol ; 24(7): 1064-1075, 2023 07.

Artigo em Inglês | MEDLINE | ID: mdl-37277654

5.

Toll-like Receptors and the Control of Immunity.

Fitzgerald, Katherine A; Kagan, Jonathan C.

Cell ; 180(6): 1044-1066, 2020 03 19.

Artigo em Inglês | MEDLINE | ID: mdl-32164908

6.

Innate Immune Signaling Organelles Display Natural and Programmable Signaling Flexibility.

Tan, Yunhao; Kagan, Jonathan C.

Cell ; 177(2): 384-398.e11, 2019 04 04.

Artigo em Inglês | MEDLINE | ID: mdl-30853218

7.

Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA.

Barnett, Katherine C; Coronas-Serna, Julia M; Zhou, Wen; Ernandes, Michael J; Cao, Anh; Kranzusch, Philip J; Kagan, Jonathan C.

Cell ; 176(6): 1432-1446.e11, 2019 03 07.

Artigo em Inglês | MEDLINE | ID: mdl-30827685

8.

Structural transitions enable interleukin-18 maturation and signaling.

Dong, Ying; Bonin, Jeffrey P; Devant, Pascal; Liang, Zhuoyi; Sever, Alexander I M; Mintseris, Julian; Aramini, James M; Du, Gang; Gygi, Stephen P; Kagan, Jonathan C; Kay, Lewis E; Wu, Hao.

Immunity ; 2024 May 08.

Artigo em Inglês | MEDLINE | ID: mdl-38733997

9.

Targeting innate immune pathways for cancer immunotherapy.

Cao, Longyue L; Kagan, Jonathan C.

Immunity ; 56(10): 2206-2217, 2023 10 10.

Artigo em Inglês | MEDLINE | ID: mdl-37703879

10.

Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis.

Miao, Rui; Jiang, Cong; Chang, Winston Y; Zhang, Haiwei; An, Jinsu; Ho, Felicia; Chen, Pengcheng; Zhang, Han; Junqueira, Caroline; Amgalan, Dulguun; Liang, Felix G; Zhang, Junbing; Evavold, Charles L; Hafner-Bratkovic, Iva; Zhang, Zhibin; Fontana, Pietro; Xia, Shiyu; Waldeck-Weiermair, Markus; Pan, Youdong; Michel, Thomas; Bar-Peled, Liron; Wu, Hao; Kagan, Jonathan C; Kitsis, Richard N; Zhang, Peng; Liu, Xing; Lieberman, Judy.

Immunity ; 56(11): 2523-2541.e8, 2023 Nov 14.

Artigo em Inglês | MEDLINE | ID: mdl-37924812

11.

Excess lipids on endosomes dictates NLRP3 localization and inflammasome activation.

Kagan, Jonathan C.

Nat Immunol ; 24(1): 3-4, 2023 01.

Artigo em Inglês | MEDLINE | ID: mdl-36596890

12.

Virus-mediated inactivation of anti-apoptotic Bcl-2 family members promotes Gasdermin-E-dependent pyroptosis in barrier epithelial cells.

Orzalli, Megan H; Prochera, Aleksandra; Payne, Laurellee; Smith, Avi; Garlick, Jonathan A; Kagan, Jonathan C.

Immunity ; 54(7): 1447-1462.e5, 2021 07 13.

Artigo em Inglês | MEDLINE | ID: mdl-33979579

13.

ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D.

Du, Gang; Healy, Liam B; David, Liron; Walker, Caitlin; El-Baba, Tarick J; Lutomski, Corinne A; Goh, Byoungsook; Gu, Bowen; Pi, Xiong; Devant, Pascal; Fontana, Pietro; Dong, Ying; Ma, Xiyu; Miao, Rui; Balasubramanian, Arumugam; Puthenveetil, Robbins; Banerjee, Anirban; Luo, Hongbo R; Kagan, Jonathan C; Oh, Sungwhan F; Robinson, Carol V; Lieberman, Judy; Wu, Hao.

Nature ; 630(8016): 437-446, 2024 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-38599239

14.

A bicistronic MAVS transcript highlights a class of truncated variants in antiviral immunity.

Brubaker, Sky W; Gauthier, Anna E; Mills, Eric W; Ingolia, Nicholas T; Kagan, Jonathan C.

Cell ; 156(4): 800-11, 2014 Feb 13.

Artigo em Inglês | MEDLINE | ID: mdl-24529381

15.

A promiscuous lipid-binding protein diversifies the subcellular sites of toll-like receptor signal transduction.

Bonham, Kevin S; Orzalli, Megan H; Hayashi, Kachiko; Wolf, Amaya I; Glanemann, Christoph; Weninger, Wolfgang; Iwasaki, Akiko; Knipe, David M; Kagan, Jonathan C.

Cell ; 156(4): 705-16, 2014 Feb 13.

Artigo em Inglês | MEDLINE | ID: mdl-24529375

16.

Structural insights into cytokine cleavage by inflammatory caspase-4.

Devant, Pascal; Dong, Ying; Mintseris, Julian; Ma, Weiyi; Gygi, Steven P; Wu, Hao; Kagan, Jonathan C.

Nature ; 624(7991): 451-459, 2023 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-37993712

17.

Control of the innate immune response by the mevalonate pathway.

Akula, Murali K; Shi, Man; Jiang, Zhaozhao; Foster, Celia E; Miao, David; Li, Annie S; Zhang, Xiaoman; Gavin, Ruth M; Forde, Sorcha D; Germain, Gail; Carpenter, Susan; Rosadini, Charles V; Gritsman, Kira; Chae, Jae Jin; Hampton, Randolph; Silverman, Neal; Gravallese, Ellen M; Kagan, Jonathan C; Fitzgerald, Katherine A; Kastner, Daniel L; Golenbock, Douglas T; Bergo, Martin O; Wang, Donghai.

Nat Immunol ; 17(8): 922-9, 2016 08.

Artigo em Inglês | MEDLINE | ID: mdl-27270400

18.

Inflammasomes: Threat-Assessment Organelles of the Innate Immune System.

Evavold, Charles L; Kagan, Jonathan C.

Immunity ; 51(4): 609-624, 2019 10 15.

Artigo em Inglês | MEDLINE | ID: mdl-31473100

19.

Defying Death: The (W)hole Truth about the Fate of GSDMD Pores.

Evavold, Charles L; Kagan, Jonathan C.

Immunity ; 50(1): 15-17, 2019 01 15.

Artigo em Inglês | MEDLINE | ID: mdl-30650374

20.

Recognition for an innate explorer.