Detalhe da pesquisa
1.
Viral clearance, pharmacokinetics and tolerability of ensovibep in patients with mild to moderate COVID-19: A phase 2a, open-label, single-dose escalation study.
Br J Clin Pharmacol
; 89(3): 1105-1114, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36214216
2.
First-in-human trial to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of STR-324, a dual enkephalinase inhibitor for pain management.
Br J Clin Pharmacol
; 88(1): 103-114, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34046921
3.
Assessment of Risks Associated With Severe Acute Respiratory Syndrome Coronavirus 2 Experimental Human Infection Studies.
Clin Infect Dis
; 73(5): e1228-e1234, 2021 09 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33249450
4.
Safety, tolerability and pharmacokinetic characterisation of DACRA KBP-042 in healthy male subjects.
Br J Clin Pharmacol
; 87(12): 4786-4796, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34019711
5.
Pharmacokinetics of fosfomycin in patients with prophylactic treatment for recurrent Escherichia coli urinary tract infection.
J Antimicrob Chemother
; 75(11): 3278-3285, 2020 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32712666
6.
The effect of food and formulation on the population pharmacokinetics of cholesteryl ester transferase protein inhibitor DRL-17822 in healthy male volunteers.
Br J Clin Pharmacol
; 86(10): 2095-2101, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32250455
7.
How to expedite early-phase SARS-CoV-2 vaccine trials in pandemic setting-A practical perspective.
Br J Clin Pharmacol
; 87(5): 2167-2169, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32557771
8.
Identifying 24 h variation in the pharmacokinetics of levofloxacin: a population pharmacokinetic approach.
Br J Clin Pharmacol
; 81(2): 256-68, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26852745
9.
Reproducibility of biomarkers in induced sputum and in serum from chronic smokers.
Pulm Pharmacol Ther
; 33: 81-6, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25966831
10.
Colistin: Revival of an Old Polymyxin Antibiotic.
Ther Drug Monit
; 37(4): 419-27, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-25549206
11.
Safety, reactogenicity and immunogenicity of an intranasal seasonal influenza vaccine adjuvanted with gram-positive matrix (GEM) particles (FluGEM): A randomized, double-blind, controlled, ascending dose study in healthy adults and elderly.
Vaccine
; 2024 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38772837
12.
Safety and immunogenicity of Ad26.COV2.S in adults: A randomised, double-blind, placebo-controlled Phase 2a dose-finding study.
Vaccine
; 42(16): 3536-3546, 2024 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38705804
13.
Immunogenicity and reactogenicity of intradermal mRNA-1273 SARS-CoV-2 vaccination: a non-inferiority, randomized-controlled trial.
NPJ Vaccines
; 9(1): 1, 2024 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38167735
14.
Early stage development of the glycine-1 re-uptake inhibitor SCH 900435: central nervous system effects compared with placebo in healthy men.
Br J Clin Pharmacol
; 75(6): 1455-67, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23116363
15.
Immunosuppression by hydroxychloroquine: mechanistic proof in in vitro experiments but limited systemic activity in a randomized placebo-controlled clinical pharmacology study.
Immunol Res
; 71(4): 617-627, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36811819
16.
Causal chemoprophylactic activity of cabamiquine against Plasmodium falciparum in a controlled human malaria infection: a randomised, double-blind, placebo-controlled study in the Netherlands.
Lancet Infect Dis
; 23(10): 1164-1174, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37414066
17.
Accelerating vaccine trial conduct in a pandemic with a hot spot-based inclusion strategy using trial and epidemic simulation.
Clin Transl Sci
; 14(6): 2391-2398, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34260149
18.
An exploratory first-in-man study to investigate the pharmacokinetics and safety of liposomal dexamethasone at a 2- and 1-week interval in patients with metastatic castration resistant prostate cancer.
Pharmacol Res Perspect
; 9(5): e00845, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34414692
19.
A novel sustained-release cysteamine bitartrate formulation for the treatment of cystinosis: Pharmacokinetics and safety in healthy male volunteers.
Pharmacol Res Perspect
; 9(2): e00739, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33764642
20.
First-in-human administration of a live-attenuated RSV vaccine lacking the G-protein assessing safety, tolerability, shedding and immunogenicity: a randomized controlled trial.
Vaccine
; 38(39): 6088-6095, 2020 09 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32718816