Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

DNAJB6, a Key Factor in Neuronal Sensitivity to Amyloidogenesis.

Thiruvalluvan, Arun; de Mattos, Eduardo P; Brunsting, Jeanette F; Bakels, Rob; Serlidaki, Despina; Barazzuol, Lara; Conforti, Paola; Fatima, Azra; Koyuncu, Seda; Cattaneo, Elena; Vilchez, David; Bergink, Steven; Boddeke, Erik H W G; Copray, Sjef; Kampinga, Harm H.

Mol Cell ; 78(2): 346-358.e9, 2020 04 16.

Artigo em Inglês | MEDLINE | ID: mdl-32268123

2.

Digest it all: the lysosomal turnover of cytoplasmic aggregates.

Mauthe, Mario; Kampinga, Harm H; Hipp, Mark S; Reggiori, Fulvio.

Trends Biochem Sci ; 48(3): 216-228, 2023 03.

Artigo em Inglês | MEDLINE | ID: mdl-36280494

3.

Cellular Handling of Protein Aggregates by Disaggregation Machines.

Mogk, Axel; Bukau, Bernd; Kampinga, Harm H.

Mol Cell ; 69(2): 214-226, 2018 01 18.

Artigo em Inglês | MEDLINE | ID: mdl-29351843

4.

mHTT Seeding Activity: A Marker of Disease Progression and Neurotoxicity in Models of Huntington's Disease.

Ast, Anne; Buntru, Alexander; Schindler, Franziska; Hasenkopf, Regine; Schulz, Aline; Brusendorf, Lydia; Klockmeier, Konrad; Grelle, Gerlinde; McMahon, Benjamin; Niederlechner, Hannah; Jansen, Isabelle; Diez, Lisa; Edel, Juliane; Boeddrich, Annett; Franklin, Sophie A; Baldo, Barbara; Schnoegl, Sigrid; Kunz, Severine; Purfürst, Bettina; Gaertner, Annette; Kampinga, Harm H; Morton, A Jennifer; Petersén, Åsa; Kirstein, Janine; Bates, Gillian P; Wanker, Erich E.

Mol Cell ; 71(5): 675-688.e6, 2018 09 06.

Artigo em Inglês | MEDLINE | ID: mdl-30193095

5.

The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model.

Kakkar, Vaishali; Månsson, Cecilia; de Mattos, Eduardo P; Bergink, Steven; van der Zwaag, Marianne; van Waarde, Maria A W H; Kloosterhuis, Niels J; Melki, Ronald; van Cruchten, Remco T P; Al-Karadaghi, Salam; Arosio, Paolo; Dobson, Christopher M; Knowles, Tuomas P J; Bates, Gillian P; van Deursen, Jan M; Linse, Sara; van de Sluis, Bart; Emanuelsson, Cecilia; Kampinga, Harm H.

Mol Cell ; 62(2): 272-283, 2016 Apr 21.

Artigo em Inglês | MEDLINE | ID: mdl-27151442

6.

FOXO1 controls protein synthesis and transcript abundance of mutant polyglutamine proteins, preventing protein aggregation.

Furtado, Gabriel Vasata; Yang, Jing; Wu, Di; Papagiannopoulos, Christos I; Terpstra, Hanna M; Kuiper, E F Elsiena; Krauss, Sybille; Zhu, Wei-Guo; Kampinga, Harm H; Bergink, Steven.

Hum Mol Genet ; 30(11): 996-1005, 2021 05 31.

Artigo em Inglês | MEDLINE | ID: mdl-33822053

7.

DNAJB chaperones suppress destabilised protein aggregation via a region distinct from that used to inhibit amyloidogenesis.

McMahon, Shannon; Bergink, Steven; Kampinga, Harm H; Ecroyd, Heath.

J Cell Sci ; 134(7)2021 04 01.

Artigo em Inglês | MEDLINE | ID: mdl-33674449

8.

Activation of IRE1, PERK and salt-inducible kinases leads to Sec body formation in Drosophila S2 cells.

Zhang, Chujun; van Leeuwen, Wessel; Blotenburg, Marloes; Aguilera-Gomez, Angelica; Brussee, Sem; Grond, Rianne; Kampinga, Harm H; Rabouille, Catherine.

J Cell Sci ; 134(17)2021 09 01.

Artigo em Inglês | MEDLINE | ID: mdl-34350957

9.

CAG Repeat Size Influences the Progression Rate of Spinocerebellar Ataxia Type 3.

Leotti, Vanessa B; de Vries, Jeroen J; Oliveira, Camila M; de Mattos, Eduardo P; Te Meerman, Gerard J; Brunt, Ewout R; Kampinga, Harm H; Jardim, Laura B; Verbeek, Dineke S.

Ann Neurol ; 89(1): 66-73, 2021 01.

Artigo em Inglês | MEDLINE | ID: mdl-32978817

10.

The HSP70 chaperone machinery: J proteins as drivers of functional specificity.

Kampinga, Harm H; Craig, Elizabeth A.

Nat Rev Mol Cell Biol ; 11(8): 579-92, 2010 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-20651708

11.

Chaperoned by prebiotic inorganic polyphosphate molecules: an ancient transcription-independent mechanism to restore protein homeostasis.

Kampinga, Harm H.

Mol Cell ; 53(5): 685-7, 2014 Mar 06.

Artigo em Inglês | MEDLINE | ID: mdl-24606917

12.

Functional diversity between HSP70 paralogs caused by variable interactions with specific co-chaperones.

Serlidaki, Despina; van Waarde, Maria A W H; Rohland, Lukas; Wentink, Anne S; Dekker, Suzanne L; Kamphuis, Maarten J; Boertien, Jeffrey M; Brunsting, Jeanette F; Nillegoda, Nadinath B; Bukau, Bernd; Mayer, Matthias P; Kampinga, Harm H; Bergink, Steven.

J Biol Chem ; 295(21): 7301-7316, 2020 05 22.

Artigo em Inglês | MEDLINE | ID: mdl-32284329

13.

The N terminus of the small heat shock protein HSPB7 drives its polyQ aggregation-suppressing activity.

Wu, Di; Vonk, Jan J; Salles, Felix; Vonk, Danara; Haslbeck, Martin; Melki, Ronald; Bergink, Steven; Kampinga, Harm H.

J Biol Chem ; 294(25): 9985-9994, 2019 06 21.

Artigo em Inglês | MEDLINE | ID: mdl-31097540

14.

Astrocytic expression of the chaperone DNAJB6 results in non-cell autonomous protection in Huntington's disease.

Bason, Matteo; Meister-Broekema, Melanie; Alberts, Niels; Dijkers, Pascale; Bergink, Steven; Sibon, Ody C M; Kampinga, Harm H.

Neurobiol Dis ; 124: 108-117, 2019 04.

Artigo em Inglês | MEDLINE | ID: mdl-30408590

15.

Distinguishing aggregate formation and aggregate clearance using cell-based assays.

Eenjes, Evelien; Dragich, Joanna M; Kampinga, Harm H; Yamamoto, Ai.

J Cell Sci ; 129(6): 1260-70, 2016 Mar 15.

Artigo em Inglês | MEDLINE | ID: mdl-26818841

16.

A DNAJB chaperone subfamily with HDAC-dependent activities suppresses toxic protein aggregation.

Hageman, Jurre; Rujano, Maria A; van Waarde, Maria A W H; Kakkar, Vaishali; Dirks, Ron P; Govorukhina, Natalia; Oosterveld-Hut, Henderika M J; Lubsen, Nicolette H; Kampinga, Harm H.

Mol Cell ; 37(3): 355-69, 2010 Feb 12.

Artigo em Inglês | MEDLINE | ID: mdl-20159555

17.

Overexpression of Cystathionine Î³-Lyase Suppresses Detrimental Effects of Spinocerebellar Ataxia Type 3.

Snijder, Pauline M; Baratashvili, Madina; Grzeschik, Nicola A; Leuvenink, Henri G D; Kuijpers, Lucas; Huitema, Sippie; Schaap, Onno; Giepmans, Ben N G; Kuipers, Jeroen; Miljkovic, Jan Lj; Mitrovic, Aleksandra; Bos, Eelke M; Szabó, Csaba; Kampinga, Harm H; Dijkers, Pascale F; Bos, Eelke M; Szabó, Csaba; Kampinga, Harm H; Dijkers, Pascale F; Dunnen, Wilfred F A den; Filipovic, Milos R; Goor, Harry van; Sibon, Ody C M.

Mol Med ; 21(1): 758-768, 2016 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-26467707

18.

Elevated mutant dynorphin A causes Purkinje cell loss and motor dysfunction in spinocerebellar ataxia type 23.

Smeets, Cleo J L M; Jezierska, Justyna; Watanabe, Hiroyuki; Duarri, Anna; Fokkens, Michiel R; Meijer, Michel; Zhou, Qin; Yakovleva, Tania; Boddeke, Erik; den Dunnen, Wilfred; van Deursen, Jan; Bakalkin, Georgy; Kampinga, Harm H; van de Sluis, Bart; Verbeek, Dineke S.

Brain ; 138(Pt 9): 2537-52, 2015 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-26169942

19.

Molecular biology: It takes two to untangle.

Kampinga, Harm H.

Nature ; 524(7564): 169-70, 2015 Aug 13.

Artigo em Inglês | MEDLINE | ID: mdl-26245378

20.

Spinocerebellar ataxia type 19/22 mutations alter heterocomplex Kv4.3 channel function and gating in a dominant manner.

Duarri, Anna; Lin, Meng-Chin A; Fokkens, Michiel R; Meijer, Michel; Smeets, Cleo J L M; Nibbeling, Esther A R; Boddeke, Erik; Sinke, Richard J; Kampinga, Harm H; Papazian, Diane M; Verbeek, Dineke S.

Cell Mol Life Sci ; 72(17): 3387-99, 2015 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-25854634

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