Detalhe da pesquisa
1.
Interrogating dense ligand chemical space with a forward-synthetic library.
Proc Natl Acad Sci U S A
; 116(23): 11496-11501, 2019 06 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31113876
2.
Refining the structure-activity relationships of 2-phenylcyclopropane carboxylic acids as inhibitors of O-acetylserine sulfhydrylase isoforms.
J Enzyme Inhib Med Chem
; 34(1): 31-43, 2019 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-30362368
3.
A Versatile Strategy for the Synthesis of 4,5-Dihydroxy-2,3-Pentanedione (DPD) and Related Compounds as Potential Modulators of Bacterial Quorum Sensing.
Molecules
; 23(10)2018 Oct 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30301207
4.
Design and synthesis of 4,5,6,7-tetrahydro-1H-1,2-diazepin-7-one derivatives as a new series of Phosphodiesterase 4 (PDE4) inhibitors.
Bioorg Med Chem Lett
; 27(1): 24-29, 2017 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27890378
5.
Genotype-phenotype complexity of the TR46/Y121F/T289A cyp51A azole resistance mechanism in Aspergillus fumigatus.
Fungal Genet Biol
; 82: 129-35, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26092193
6.
Design and synthesis of 1,1-disubstituted-1-silacycloalkane-based compound libraries.
Bioorg Med Chem
; 23(11): 2716-20, 2015 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25680845
7.
Aspergillosis due to voriconazole highly resistant Aspergillus fumigatus and recovery of genetically related resistant isolates from domiciles.
Clin Infect Dis
; 57(4): 513-20, 2013 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-23667263
8.
The structure-function relationship of the Aspergillus fumigatuscyp51A L98H conversion by site-directed mutagenesis: the mechanism of L98H azole resistance.
Fungal Genet Biol
; 48(11): 1062-70, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-21907818
9.
Azole resistance profile of amino acid changes in Aspergillus fumigatus CYP51A based on protein homology modeling.
Antimicrob Agents Chemother
; 54(6): 2425-30, 2010 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-20385860
10.
DPD-Inspired Discovery of Novel LsrK Kinase Inhibitors: An Opportunity To Fight Antimicrobial Resistance.
J Med Chem
; 62(5): 2720-2737, 2019 03 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30786203
11.
Modulators of 14-3-3 Protein-Protein Interactions.
J Med Chem
; 61(9): 3755-3778, 2018 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28968506
12.
Properties of flavonoids influencing the binding to bilitranslocase investigated by neural network modelling.
Biochem Pharmacol
; 73(2): 308-20, 2007 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17081502
13.
Stabilization of protein-protein interactions in drug discovery.
Expert Opin Drug Discov
; 12(9): 925-940, 2017 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28695752
14.
Mechanism of bleomycin suicide: a Car-Parrinello molecular dynamics investigation.
J Phys Chem B
; 110(42): 21245-50, 2006 Oct 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-17048952
15.
The European Lead Factory: A Blueprint for Public-Private Partnerships in Early Drug Discovery.
Front Med (Lausanne)
; 3: 75, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-28154815
16.
Design and Synthesis of Fsp(3)-Rich, Bis-Spirocyclic-Based Compound Libraries for Biological Screening.
ACS Comb Sci
; 18(6): 330-6, 2016 06 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-27163646
17.
Expansion of chemical space for collaborative lead generation and drug discovery: the European Lead Factory Perspective.
Drug Discov Today
; 20(11): 1310-6, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26429298
18.
Triazole fungicides can induce cross-resistance to medical triazoles in Aspergillus fumigatus.
PLoS One
; 7(3): e31801, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22396740
19.
The non-gastric H,K-ATPase as a tool to study the ouabain-binding site in Na,K-ATPase.
Pflugers Arch
; 457(3): 623-34, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18324411
20.
The metal bonding domain of the antitumor drug Fe(II)-bleomycin: a DFT investigation.
J Biol Inorg Chem
; 10(1): 33-40, 2005 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-15578242