Detalhe da pesquisa
1.
Scaffold hopping via ring opening enables identification of acyclic compounds as new complement Factor D inhibitors.
Bioorg Med Chem
; 74: 117034, 2022 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36272185
2.
Discovery and optimization of orally bioavailable and potent plasma Kallikrein inhibitors bearing a quaternary carbon.
Bioorg Med Chem
; 73: 117035, 2022 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36208543
3.
Synthesis and biological evaluation of Ribo 7-N/O/S pyrimidine 9-deaza C-nucleoside analogs as new antiviral agents for inhibiting HCV RNA-dependent RNA polymerases.
Eur J Med Chem
; 264: 115991, 2024 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38118393
4.
Berotralstat (BCX7353): Structure-Guided Design of a Potent, Selective, and Oral Plasma Kallikrein Inhibitor to Prevent Attacks of Hereditary Angioedema (HAE).
J Med Chem
; 64(17): 12453-12468, 2021 09 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34436898