Detalhe da pesquisa
1.
Spatiotemporal regulation of NADP(H) phosphatase Nocturnin and its role in oxidative stress response.
Proc Natl Acad Sci U S A
; 117(2): 993-999, 2020 01 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31879354
2.
The phenylketonuria-associated substitution R68S converts phenylalanine hydroxylase to a constitutively active enzyme but reduces its stability.
J Biol Chem
; 294(12): 4359-4367, 2019 03 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-30674554
3.
Phosphorylation of Phenylalanine Hydroxylase Increases the Rate Constant for Formation of the Activated Conformation of the Enzyme.
Biochemistry
; 57(44): 6274-6277, 2018 11 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30346142
4.
Thermal profiling reveals phenylalanine hydroxylase as an off-target of panobinostat.
Nat Chem Biol
; 12(11): 908-910, 2016 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-27669419
5.
Domain Movements upon Activation of Phenylalanine Hydroxylase Characterized by Crystallography and Chromatography-Coupled Small-Angle X-ray Scattering.
J Am Chem Soc
; 138(20): 6506-16, 2016 05 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-27145334
6.
Activation of phenylalanine hydroxylase by phenylalanine does not require binding in the active site.
Biochemistry
; 53(49): 7846-53, 2014 Dec 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-25453233
7.
Mutagenesis of a specificity-determining residue in tyrosine hydroxylase establishes that the enzyme is a robust phenylalanine hydroxylase but a fragile tyrosine hydroxylase.
Biochemistry
; 52(8): 1446-55, 2013 Feb 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-23368961