Detalhe da pesquisa
1.
Synthesis and discovery of the first potent proteolysis targeting chimaera (PROTAC) degrader of AIMP2-DX2 as a lung cancer drug.
J Enzyme Inhib Med Chem
; 38(1): 51-66, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-36305287
2.
Targeting the interaction of AIMP2-DX2 with HSP70 suppresses cancer development.
Nat Chem Biol
; 16(1): 31-41, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31792442
3.
Allosteric Inhibition of the Tumor-Promoting Interaction Between Exon 2-Depleted Splice Variant of Aminoacyl-Transfer RNA Synthetase-Interacting Multifunctional Protein 2 and Heat Shock Protein 70.
J Pharmacol Exp Ther
; 379(3): 358-371, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34503993
4.
First Report of Colletotrichum siamense Causing Anthracnose of Chili Pepper Fruit in Korea.
Plant Dis
; 2020 Dec 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-33373288
5.
Anticancer Activity of Pyrimethamine via Ubiquitin Mediated Degradation of AIMP2-DX2.
Molecules
; 25(12)2020 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32549310
6.
Purification and biophysical characterization of the AIMP2-DX2 protein.
Protein Expr Purif
; 132: 131-137, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28185908
7.
Promiscuous methionyl-tRNA synthetase mediates adaptive mistranslation to protect cells against oxidative stress.
J Cell Sci
; 127(Pt 19): 4234-45, 2014 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25097229
8.
Chemical inhibition of prometastatic lysyl-tRNA synthetase-laminin receptor interaction.
Nat Chem Biol
; 10(1): 29-34, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24212136
9.
Identification of CD23 as a functional receptor for the proinflammatory cytokine AIMP1/p43.
J Cell Sci
; 125(Pt 19): 4620-9, 2012 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22767513
10.
Chemical suppression of an oncogenic splicing variant of AIMP2 induces tumour regression.
Biochem J
; 454(3): 411-6, 2013 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23815603
11.
Cancer-associated splicing variant of tumor suppressor AIMP2/p38: pathological implication in tumorigenesis.
PLoS Genet
; 7(3): e1001351, 2011 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-21483803
12.
Crystal structure of human cytosolic aspartyl-tRNA synthetase, a component of multi-tRNA synthetase complex.
Proteins
; 81(10): 1840-6, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23609930
13.
Interaction of two translational components, lysyl-tRNA synthetase and p40/37LRP, in plasma membrane promotes laminin-dependent cell migration.
FASEB J
; 26(10): 4142-59, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22751010
14.
AIMP2-DX2 provides therapeutic interface to control KRAS-driven tumorigenesis.
Nat Commun
; 13(1): 2572, 2022 05 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35546148
15.
2-Aminophenylpyrimidines as Novel Inhibitors of Aminoacyl-tRNA Synthetase Interacting Multifunctional Protein 2 (AIMP2)-DX2 for Lung Cancer Treatment.
J Med Chem
; 63(8): 3908-3914, 2020 04 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32208684
16.
Synthesis and Structure-Activity Relationships of Arylsulfonamides as AIMP2-DX2 Inhibitors for the Development of a Novel Anticancer Therapy.
J Med Chem
; 63(10): 5139-5158, 2020 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-32315177
17.
An Isoform of the Oncogenic Splice Variant AIMP2-DX2 Detected by a Novel Monoclonal Antibody.
Biomolecules
; 10(6)2020 05 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-32471182
18.
ERK-dependent phosphorylation of the linker and substrate-binding domain of HSP70 increases folding activity and cell proliferation.
Exp Mol Med
; 51(9): 1-14, 2019 09 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-31558706
19.
Data on optimization of expression and purification of AIMP2-DX2 protein in Escherichia coli.
Data Brief
; 11: 533-536, 2017 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-28367482
20.
Suppression of lysyl-tRNA synthetase, KRS, causes incomplete epithelial-mesenchymal transition and ineffective cellextracellular matrix adhesion for migration.
Int J Oncol
; 48(4): 1553-60, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26891990