Cigarette use and binge drinking among Korean adolescents: examining the moderating role of multicultural status.

Cigarette is usually used conjointly with alcohol however its impact may vary with how much alcohol is being consumed. Besides the general use of alcohol, this study specifically focused on identifying the association between cigarette use and binge drinking of Korean adolescents. Furthermore, it aims to testify whether the multicultural status plays a moderating role in this relationship, and to discover other problem behavior theory constructs that may be associated with binge drinking of the Korean adolescents. Using the nationally representative data from the 2018 Korea Youth Health Risk Survey, 60,040 students were selected to perform chi-square, t-test, and hierarchical multiple regression. There was a strong association between cigarette use and binge drinking, and multicultural status had the moderating effect in this relationship. More specifically, adolescents from the multicultural families had higher levels of cigarette use and binge drinking than the non-multicultural adolescents. Besides these main findings, covariates such as suicidal ideation, sexual intercourse, e-cigarette use, and harmful experiences from the alcohol use of others were found to be the additional significant factors of Korean adolescents' binge drinking. Based on these findings, author suggests for the combined interventions for alcohol and tobacco, and raise awareness on the possible health disparities that could occur between multicultural families and non-multicultural families in South Korea.

Fidelity assessment of the suicide reporting guidelines in Korean newspapers.

BACKGROUND: With the dishonor of being the highest suicide rated country in Organisation for Economic Co-operation and Development, South Korea should take more initiatives in suicide prevention. Although the role of the media and its relation to actual suicide attempts has been tested and supported by many studies, the suicide reporting guidelines are not well followed. The purpose of this study is to examine how well Korean newspapers adhere to existing guidelines and to suggest limitation and improvements for the current guidelines. METHODS: Five mainstream newspapers in South Korea, namely, Kyunghyang Shinmun, Hankyoreh, Chosun Ilbo, JoongAng Daily, and Dong-A Ilbo, were chosen for the analysis. Using the Naver news search engine, articles dated from January 1, 2014, to December 31, 2017, were selected with the keyword "suicide" and advanced option "printed newspaper." However, articles, columns, opinions, and reviews that utilized the word "suicide" in a general context were excluded from the final analysis. Finally, the number of cases was narrowed down to 368. Each article was analyzed using the guideline framework consisting of 13 items: sensational coverage, overstatement, direct wording, method used, details about site/location, photographs, suicide note, generalization, speculation, romanticization, interviews with the bereaved, help-seeking information, and public education. RESULTS: More than 60% of the articles included direct wording (63.9%), mentioned the method used (68.2%), and provided details about the site or location (74.5%). Nearly half of the articles revealed the contents of the suicide note (44.6%). Less than 3% of the suicide reports had information about hotline logo or phone numbers (1.4%) and facts regarding suicide and suicide prevention (2.2%). CONCLUSIONS: Our study revealed that the guidelines were ineffective in their monitoring role and that most of the newspapers were incompliant with many significant guideline items in South Korea. Our findings not only explore the limitations of the current guidelines but also provide an important rationale as to why there should be stronger suicide monitoring regulation or an agency with sufficient authority to prevent suicide in a nation-wide scale.

Caseworker Visitation After Reunification and Children's Reentry Into Foster Care: A Survival Analysis.

To prevent children from reentering the welfare system, it is crucial to understand the role of caseworker visits after reunification on reentry and identify the factors related to reentry. Utilizing the administrative data of one Mid-Atlantic state, children who reunified with their families between July 2016 and June 2020 were selected as the study sample (N = 3,510). Reentry rates were higher for children who did not have caseworker visits after reunification than for those who did. The survival analysis revealed that male children, living in metropolitan areas, having a prior history of removal, having a behavioral issue, and court-ordered return increased the risk of reentry, while Black children, older children, having a last placement as trial home visit, and caseworker visits after reunification decreased the risk of reentry. The study suggests formally outlining policies for post-reunification caseworker visits and increasing collaboration between the child welfare system and court system.

Factors associated with Korean adolescent's e-cigarette use by the severity level of generalized anxiety disorder (GAD-7).

BACKGROUND: The use of e-cigarette among Korean adolescents is spreading with alarming rapidity, but it has not been studied along with the severity level of GAD-7. This study aims to identify adolescents' e-cigarette use and its associated factors among four different anxiety groups using the problem behavioral theory (PBT). METHODS: A cross-sectional secondary dataset was retrieved from the 2020 Korea Youth Risk Behavior Survey. Of the total sample of 54,948, four anxiety groups were formed: minimal (score 0-4; n = 36,711), mild (score 5-9; n = 12,138), moderate (score 10-14; n = 4143), and severe (score above 15; n = 1965). A total of 11 variables were selected based on the PBT domains. Descriptive analysis, Chi-square, ANOVA, univariate analysis, and multiple linear regression analysis were performed. RESULTS: E-cigarette use was the highest in the order of severe, mild, moderate, and minimal. While cigarette use was associated with vaping in all anxiety groups, adolescents with minimal or mild anxiety levels were more likely to be influenced by tobacco accessibility and other behavior system factors such as sexual intercourse, alcohol use, and smartphone addiction. Meanwhile, secondhand smoke exposure in public areas was only associated with those with severe anxiety levels, and secondhand smoke exposure at school was a significant factor in all anxiety groups except for those with moderate anxiety levels. LIMITATION: Due to the nature of cross-sectional dataset, the study could not draw causal links between vaping and other identified factors, include all the necessary PBT components. CONCLUSION: These findings underscore the need to consider different levels of anxiety when addressing the problems related to vaping among Korean adolescents.

Factors Associated With Permanency for Children in Out-Of-Home Placement: A Survival Analysis.

Achieving permanency is a main goal of the child welfare system. To promote timely achievement of permanency, it is important to understand the determinants associated with permanency outcomes. This study aims to examine the length of time children spend in foster care and identify factors associated with achievement of permanency using administrative data from one state spanning a six-year timeframe and including a final sample of 1,874 children. Determinants associated with achievement of permanency were examined through multivariate survival analyses using Cox proportional hazards regression models. The median length of time in days to achieve permanency was: 188 for reunification, 505 for guardianship, and 932 for adoption. Race/ethnicity, age at removal, number of placement changes, number of siblings, having a removal family team decision meeting (FTDM), and placement type were significantly associated with achievement of permanency. Given the findings, this article proposes implications for practice and policy surrounding racial disproportionality, family engagement, kinship care, and placement stability.

Impact of COVID-19 on Adolescents' Smartphone Addiction in South Korea.

The outbreak of COVID-19 impacted numerous people globally, but most notably affected adolescents negatively by contributing to the increase in their use of media and smartphones and therefore their susceptibility to smartphone addiction. Based on the social-ecological model, this study seeks to identify the individual-, family-, and school-level factors of smartphone addiction through two groups of users: a first group whose smartphone usage time increased after the outbreak of COVID-19, and a second group whose usage time did not. Based on the data collected from 360 Korean adolescents aged 15 to 18, results reveal that personal-level factors (i.e., gender, depressive symptoms, self-control, and cyberbullying victimization) are associated with smartphone addiction. For the group whose smartphone usage time increased after the outbreak, economic status, academic performance, and academic year were related to smartphone addiction. Based on these findings, the study makes specific guidelines and suggestions on addressing the smartphone addiction among Korean adolescents.

The matrix metalloproteinase-7 regulates the extracellular shedding of syndecan-2 from colon cancer cells.

The cell surface heparan sulfate proteoglycan syndecan-2 regulates the activation of matrix metalloproteinase-7 (MMP-7) as a docking receptor. Here, we demonstrate the role of MMP-7 on syndecan-2 shedding in colon cancer cells. Western blot analysis showed that shed syndecan-2 was found in the culture media from various colon cancer cells. Overexpression of MMP-7 enhanced syndecan-2 shedding, whereas the opposite was true when MMP-7 levels were knocked-down using small inhibitory RNAs. Consistently, HT29 cells treated with MMP-7, but neither MMP-2 nor MMP-9, showed increased shed syndecan-2 in a time- and concentration-dependent manner. Furthermore, MALDI-TOF MS analysis and N-terminal amino acid sequencing revealed that MMP-7 cleaved both recombinant syndecan-2 and an endogenously glycosylated syndecan-2 ectodomain in the N-terminus at Leu(149) residue in vitro. Taken together, the data suggest that MMP-7 directly mediates shedding of syndecan-2 from colon cancer cells.

An International Systematic Review of Prevalence, Risk, and Protective Factors Associated with Young People's E-Cigarette Use.

While the prevalence of young people's conventional cigarette use has decreased in many countries, the use of e-cigarettes has risen. To effectively counteract the growing popularity of e-cigarettes among young people internationally, researchers should know the exact prevalence as well as the protective and risk factors associated with vaping. Based on five eligibility criteria, 53 articles were chosen and analyzed by general characteristics, prevalence, sample characteristics, gender difference, protective factors, and risk factors. In this study, the international pooled prevalence of young people's lifetime e-cigarette use was 15.3%, the current use was 7.7%, and dual use was 4.0%. While the highest lifetime, current, and dual prevalence were found in Sweden, Canada, and the United Kingdom, respectively, the lowest prevalence was found in Germany, followed by South Korea and Sweden. Some protective and risk factors include perceived cost and danger of vaping, parental monitoring, internal developmental assets, cigarette use, family and peer smoking, exposure to online advertisements, and the presence of nearby retail stores. Based on this review, researchers and practitioners can develop different intervention programs and strategies for young smokers.

A Social-Ecological Approach to Understanding the Relationship between Cyberbullying Victimization and Suicidal Ideation in South Korean Adolescents: The Moderating Effect of School Connectedness.

BACKGROUND: Cyberbullying victimization and suicidal ideation are both ongoing deleterious social problems in South Korea. Using the social-ecological approach, this study examined the association between cyberbullying victimization and suicidal ideation as well as the buffering role of school connectedness in this relationship. METHODS: A nationally representative sample of 7333 adolescents from the 2016 Korean Children and Youth Right Study participated in the study. Data were analyzed using descriptive statistics, Wald chi-square test, bivariate correlations, and multivariate logistic regression analyses. RESULTS: Nearly 17.7% of adolescents were cyberbullied, and 28.4% had suicidal ideation in the past 12 months. Cyberbullying victims were at an increased risk of suicidal ideation. The results also found that parental abuse, family dysfunction, and perceived peer relationship stress were positively associated with suicidal ideation, while parental support for autonomy was negatively associated with suicidal ideation. Further, school connectedness moderated on the relationship between cyberbullying victimization and adolescent suicidal ideation. CONCLUSIONS: These findings suggest that various stakeholders should consider interventions and preventive programs that address school connectedness when working with adolescents who are victims of cyberbullying and exhibit suicidal behavior.

E-Cigarette, Cigarette, and Dual Use in Korean Adolescents: A Test of Problem Behavior Theory.

E-cigarettes are becoming increasingly popular among adolescent cigarette users. However, little is known about the various factors related to adolescents' use of e-cigarettes, cigarettes, or both in South Korea. Using nationally representative data from the 2017 Korea Youth Risk Behavior Web-based Survey, this study examined the possible problem behavior theory factors that contribute to (1) current e-cigarette use among those who have ever used cigarettes (Model 1), (2) current cigarette use among those who have ever used e-cigarettes (Model 2), and (3) current dual use among current cigarette or e-cigarette users (Model 3). In all three models, our analysis showed that tobacco accessibility and sexual intercourse were significant factors. For Model 2, reasons for using e-cigarettes and alcohol use were correlated with current cigarette use. Except for gender, the significant factors, which included secondhand smoke exposure at home and school type, were the same in Models 1 and 3. Based on these findings, we encourage the South Korean government to pay close attention to potential increase in dual use among adolescents and to take the necessary steps in addressing adolescent e-cigarette use in tobacco prevention and control programs.

Alzheimer's disease drug discovery from herbs: neuroprotectivity from beta-amyloid (1-42) insult.

OBJECTIVE: To comparatively evaluate selected herbs for their ability to protect neuronal cells from direct betaA(1-42) insult. DESIGN: Twenty-seven (27) herbs were selected, extracted with aqueous methanol (90%) and chloroform, and the extracts were evaluated for their ability to protect PC12 rat pheochromocytoma and primary neuronal cells from betaA(1-42) insult using both 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide reduction assay and lactate dehydrogenase efflux assay. RESULTS: Curcuma aromatia (ul-keum) and Zingiber officinale (ginger) extracts effectively protected cells from betaA(1-42) insult, followed by Ginkgo biloba (ginkgo), Polygonatum sp. (King Solomon's seal), Cinnamum cassia (Chinese cinnamon), Rheum coreanum (Korean rhubarb), Gastrodia elata (gastrodia), and Scutellaria baicalensis (skullcap). Several extracts showed cytotoxicity at high concentration (approximately 150 microg/mL), whereas other extracts did not at all protect cells from betaA(1-42) insult. CONCLUSION: Selective herbs may be potentially important resources to discover drug candidates against the onset of Alzheimer's disease.