Prioritize carbon pricing over fossil-fuel subsidy reform.

While many climate activist groups enthusiastically advocate for the removal of fossil-fuel subsidies, we argue that this overstates both the climate effectiveness and political feasibility of such a strategy. Through synthesizing information from various global studies, we show that subsidies contribute to a relatively small portion of climate change and local externality problems, likely accounting for around 1%. We further argue that reform of fossil-fuel subsidies is hampered by various political and social factors, more so than the diffusion of carbon pricing. Based on these results, we argue that the far greater problem of unpriced externalities warrants a redirection or expansion of the enthusiasm for subsidy reform toward carbon pricing. This makes sense also as subsidy reform and carbon pricing essentially represent two sides of the same coin since both contribute to climate mitigation by raising fossil-fuel prices.

Mental health difficulties among professional jockeys: a narrative review.

INTRODUCTION: Emerging academic literature and high-profile disclosures of mental health difficulties and mental illness from current and former professional jockeys suggest that further exploration of the mental health of jockeys is required. To date, a comprehensive review of jockeys' mental health has yet to be conducted. OBJECTIVES: To examine the existing literature related to jockeys' mental health, including the prevalence of symptoms associated with mental health difficulties and help-seeking. DESIGN: A narrative review of the literature was conducted with articles screened from inception until January 2021. RESULTS: Sixteen studies were included in the narrative review. Studies covered a range of mental health difficulties which included mood (depression), anxiety, distress, disordered eating and substance misuse. Rates of help-seeking among jockeys were also explored. Results indicated that jockeys reported higher levels of depressive and anxiety symptoms compared with other elite athletes. Substance misuse, in particular adverse alcohol use, also appears greater among jockeys than other elite athletes. Distress symptoms appear comparable with other elite athletes. Risk factors for mental health difficulties included injury, perceived stress, athlete burnout, career dissatisfaction and the contemplation of retirement. Weight-making negatively impacts jockeys' mood and attitudes towards eating, with lower competitive riding weights associated with more disordered eating attitudes. Moreover, help-seeking from mental health professionals appears low. CONCLUSION: The review identifies a high prevalence of symptoms of mental health difficulties among professional jockeys. Applied recommendations and future research considerations are proposed throughout the review article.

Racehorse Trainer Mental Health: Prevalence and Risk Factors.

Racehorse trainers play an important role within the horseracing industry. Despite this, scarce empirical information exists regarding the mental health of this population. Thus, the purpose of the present study was to explore the prevalence of symptoms related to common mental disorders (CMDs) and their associations with specific risk factors for CMD. Participants completed an anonymous online questionnaire. CMDs were assessed including distress, depression, generalized anxiety and adverse alcohol use. The risk factors examined included career dissatisfaction, social support and financial difficulties. 124 participants (28% response rate) completed the questionnaire. In total, 45% met the threshold indicative of at least one CMD. Specifically, prevalence of symptoms associated with depression (41%), adverse alcohol use (38%), psychological distress (26%), and generalized anxiety (18%) was observed. Career dissatisfaction (28%) and financial difficulties (64%) were identified. Career dissatisfaction, lower levels of social support and financial difficulties all increased the likelihood of trainers meeting the criteria for at least one of distress, depression or generalized anxiety. The study was the first to highlight prevalence rates of symptoms associated with CMDs among racehorse trainers in Ireland and identify certain risk factors which may increase the likelihood of racehorse trainers meeting the criteria for a CMD. Assessment of risk factors can aid early identification of CMDs among racehorse trainers. Such benefits may include early diagnosis or signposting to professional support. Further research is required in examining other occupational stressors experienced by trainers and the impact these may have on symptoms of CMDs.

Plasmodium falciparum LipB mutants display altered redox and carbon metabolism in asexual stages and cannot complete sporogony in Anopheles mosquitoes.

Malaria is still one of the most important global infectious diseases. Emergence of drug resistance and a shortage of new efficient antimalarials continue to hamper a malaria eradication agenda. Malaria parasites are highly sensitive to changes in the redox environment. Understanding the mechanisms regulating parasite redox could contribute to the design of new drugs. Malaria parasites have a complex network of redox regulatory systems housed in their cytosol, in their mitochondrion and in their plastid (apicoplast). While the roles of enzymes of the thioredoxin and glutathione pathways in parasite survival have been explored, the antioxidant role of α-lipoic acid (LA) produced in the apicoplast has not been tested. To take a first step in teasing a putative role of LA in redox regulation, we analysed a mutant Plasmodium falciparum (3D7 strain) lacking the apicoplast lipoic acid protein ligase B (lipB) known to be depleted of LA. Our results showed a change in expression of redox regulators in the apicoplast and the cytosol. We further detected a change in parasite central carbon metabolism, with lipB deletion resulting in changes to glycolysis and tricarboxylic acid cycle activity. Further, in another Plasmodium cell line (NF54), deletion of lipB impacted development in the mosquito, preventing the detection of infectious sporozoite stages. While it is not clear at this point if the observed phenotypes are linked, these findings flag LA biosynthesis as an important subject for further study in the context of redox regulation in asexual stages, and point to LipB as a potential target for the development of new transmission drugs.

Cohort profile: a migratory cohort study of US Marines who train in Australia.

PURPOSE: In 2012, US Marines and Sailors began annual deployments to Australia to participate in joint training exercises with the Australian Defence Force and other partners in the region. During their training, US service members are exposed to a variety of infectious disease threats not normally encountered by American citizens. This paper describes a cohort of US Marines and Sailors enrolled during five rotations to Australia between 2016 and 2020. PARTICIPANTS: Study participation is strictly voluntary. Group informational sessions are held prior to deployment to describe the study structure and goals, as well as the infectious disease threats that participants may encounter while in Australia. All participants provided written informed consent. Consented participants complete a pre-deployment questionnaire to collect data including basic demographic information, military occupational specialty, travel history, family history, basic health status and personal habits such as alcohol consumption. Blood is collected for serum, plasma and peripheral blood mononuclear cells (PBMC) processing. Data and specimen collection is repeated up to three times: before, during and after deployment. FINDINGS TO DATE: From the five rotations that comprised the 2016-2020 Marine Rotational Force-Darwin, we enrolled 1289 volunteers. Enrolments during this period were overwhelmingly white male under the age of 24 years. Most of the enrollees were junior enlisted and non-commissioned officers, with a smaller number of staff non-commissioned officers and commissioned officers, and minimal warrant officers. Over half of the enrollees had occupational specialty designations for infantry. FUTURE PLANS: In the future, we will screen samples for serological evidence of infection with Burkholderia pseudomallei, Coxiella burnetii, Ross River virus, SARS-CoV-2 and other operationally relevant pathogens endemic in Australia. Antigenic stimulation assays will be performed on PBMCs collected from seropositive individuals to characterise the immune response to these infections in this healthy American population.

Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP.

We have identified the plant biflavonoid hinokiflavone as an inhibitor of splicing in vitro and modulator of alternative splicing in cells. Chemical synthesis confirms hinokiflavone is the active molecule. Hinokiflavone inhibits splicing in vitro by blocking spliceosome assembly, preventing formation of the B complex. Cells treated with hinokiflavone show altered subnuclear organization specifically of splicing factors required for A complex formation, which relocalize together with SUMO1 and SUMO2 into enlarged nuclear speckles containing polyadenylated RNA. Hinokiflavone increases protein SUMOylation levels, both in in vitro splicing reactions and in cells. Hinokiflavone also inhibited a purified, E. coli expressed SUMO protease, SENP1, in vitro, indicating the increase in SUMOylated proteins results primarily from inhibition of de-SUMOylation. Using a quantitative proteomics assay we identified many SUMO2 sites whose levels increased in cells following hinokiflavone treatment, with the major targets including six proteins that are components of the U2 snRNP and required for A complex formation.

Changes in selected parameters of health and physical fitness following a sixteen-week deployment at sea.

The effects of 16 weeks at sea upon selected parameters of health and physical fitness were investigated in 30 male volunteers (from a total crew of 48 men) prior to, and immediately following deployment. The 30 subjects were assigned to either an exercise group, 'Ex' (n = 12), or a non-exercising group, 'Nilex' (n = 18), according to their reported participation in vigorous training or sports. Body mass index (BMI), calculated from height and weight, revealed that prior to deployment 13 of the 30 subjects (two in the Ex group) had a BMI over 25 kg.m-2 (i.e. overweight), and a further three subjects (all 'non-exercisers') had values of 30 kg.m-2 or more (obese). In addition, the diastolic blood pressure of two subjects was in excess of 95 mmHg and five subjects had resting heart rates above 89 beats per minute. Retrospective comparisons between the Ex and Nilex groups revealed a significantly lower percentage body fat (P < 0.01) and a faster rate of cardiac recovery (P < 0.05) following a standardised bout of exercise in the Ex group, albeit that these individuals were significantly younger (mean age of 24 years) than those in the Nilex group (32 years). Following deployment, in the Nilex group, comparison of pre- and post values showed that resting heart rate was elevated (P < 0.01) on return from sea. Similarly, in the Nilex group heart rate while performing the standardised exercise bout was also elevated (P < 0.05) on the second test occasion.(ABSTRACT TRUNCATED AT 250 WORDS)

Congenital cytomegalic inclusion disease following intrauterine transfusion.

Congenital cytomegalic inclusion disease occurring in two infants who received intrauterine transfusions for severe haemolytic disease due to rhesus isoimmunization may have been transmitted in the donor blood.