1.
Bioorg Med Chem Lett
; 14(1): 95-8, 2004 Jan 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-14684306
RESUMO
Structure-activity relationship (SAR) studies of 2-[3-di(and tri)fluoromethyl-5-arylpyrazol-1-yl]-5-methanesulfonylpyridine derivatives for canine COX enzymes are described. This led to the identification of 12a as a lead candidate for further progression. The in vitro and in vivo activity of 12a for the canine COX-2 enzyme as well as its in vivo efficacy and pharmacokinetic properties in dog are highlighted.