Detalhe da pesquisa
1.
Structure-guided enzymology of the lipid A acyltransferase LpxM reveals a dual activity mechanism.
Proc Natl Acad Sci U S A
; 113(41): E6064-E6071, 2016 10 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27681620
2.
Discovery of imidazo[1,2-a]-pyridine inhibitors of pan-PI3 kinases that are efficacious in a mouse xenograft model.
Bioorg Med Chem Lett
; 26(3): 742-746, 2016 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26774655
3.
Structure guided optimization of a fragment hit to imidazopyridine inhibitors of PI3K.
Bioorg Med Chem Lett
; 23(16): 4652-6, 2013 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23820386
4.
Identification and structure-activity relationship of 2-morpholino 6-(3-hydroxyphenyl) pyrimidines, a class of potent and selective PI3 kinase inhibitors.
Bioorg Med Chem Lett
; 20(23): 6895-8, 2010 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21035331
5.
Potent, Selective, and Orally Bioavailable Inhibitors of VPS34 Provide Chemical Tools to Modulate Autophagy in Vivo.
ACS Med Chem Lett
; 7(1): 72-6, 2016 Jan 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26819669
6.
Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.
Nat Cell Biol
; 16(11): 1069-79, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25327288