Detalhe da pesquisa
1.
CMCdG, a Novel Nucleoside Analog with Favorable Safety Features, Exerts Potent Activity against Wild-Type and Entecavir-Resistant Hepatitis B Virus.
Antimicrob Agents Chemother
; 63(4)2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30670420
2.
Active-site deformation in the structure of HIV-1 RT with HBV-associated septuple amino acid substitutions rationalizes the differential susceptibility of HIV-1 and HBV against 4'-modified nucleoside RT inhibitors.
Biochem Biophys Res Commun
; 509(4): 943-948, 2019 02 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-30648556
3.
4'-modified nucleoside analogs: potent inhibitors active against entecavir-resistant hepatitis B virus.
Hepatology
; 62(4): 1024-36, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26122273
4.
Diastereoselective Synthesis of 6â³-(Z)- and 6â³-(E)-Fluoro Analogues of Anti-hepatitis B Virus Agent Entecavir and Its Evaluation of the Activity and Toxicity Profile of the Diastereomers.
J Org Chem
; 81(7): 2827-36, 2016 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27009432
5.
Intraperitoneal administration of synthetic microRNA-214 elicits tumor suppression in an intraperitoneal dissemination mouse model of canine hemangiosarcoma.
Vet Res Commun
; 46(2): 447-457, 2022 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-34988875
6.
Structural features in common of HBV and HIV-1 resistance against chirally-distinct nucleoside analogues entecavir and lamivudine.
Sci Rep
; 10(1): 3021, 2020 02 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32080249
7.
Synthesis and evaluation of the anti-hepatitis B virus activity of 4'-Azido-thymidine analogs and 4'-Azido-2'-deoxy-5-methylcytidine analogs: structural insights for the development of a novel anti-HBV agent.
Nucleosides Nucleotides Nucleic Acids
; 39(4): 518-529, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-31514570
8.
Potent activity of a nucleoside reverse transcriptase inhibitor, 4'-ethynyl-2-fluoro-2'-deoxyadenosine, against human immunodeficiency virus type 1 infection in a model using human peripheral blood mononuclear cell-transplanted NOD/SCID Janus kinase 3 knockout mice.
Antimicrob Agents Chemother
; 53(9): 3887-93, 2009 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-19546363
9.
2'-deoxy-4'-C-ethynyl-2-halo-adenosines active against drug-resistant human immunodeficiency virus type 1 variants.
Int J Biochem Cell Biol
; 40(11): 2410-20, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18487070
10.
The High Genetic Barrier of EFdA/MK-8591 Stems from Strong Interactions with the Active Site of Drug-Resistant HIV-1 Reverse Transcriptase.
Cell Chem Biol
; 25(10): 1268-1278.e3, 2018 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-30174310
11.
Pharmacokinetics studies of 4'-cyano-2'-deoxyguanosine, a potent inhibitor of the hepatitis B virus, in rats.
J Pharm Pharmacol
; 70(6): 723-731, 2018 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-29528116
12.
HIV-1 with HBV-associated Q151M substitution in RT becomes highly susceptible to entecavir: structural insights into HBV-RT inhibition by entecavir.
Sci Rep
; 8(1): 1624, 2018 01 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-29374261
13.
Pharmacokinetic properties of a novel inosine analog, 4'-cyano-2'-deoxyinosine, after oral administration in rats.
PLoS One
; 13(6): e0198636, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29874291
14.
2'-deoxy-4'-C-ethynyl-2-fluoroadenosine: a nucleoside reverse transcriptase inhibitor with highly potent activity against wide spectrum of HIV-1 strains, favorable toxic profiles, and stability in plasma.
Nucleosides Nucleotides Nucleic Acids
; 26(10-12): 1543-6, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-18066823
15.
A novel entecavir analogue constructing with a spiro[2.4]heptane core structure in the aglycon moiety: Its synthesis and evaluation for anti-hepatitis B virus activity.
Nucleosides Nucleotides Nucleic Acids
; 36(7): 463-473, 2017 Jul 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28574799
16.
Design, Synthesis, and Evaluation of Anti-HBV Activity of Hybrid Molecules of Entecavir and Adefovir: Exomethylene Acycloguanine Nucleosides and Their Monophosphate Derivatives.
Nucleosides Nucleotides Nucleic Acids
; 34(8): 590-602, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26167667
17.
Potential of 4'-C-substituted nucleosides for the treatment of HIV-1.
Antivir Chem Chemother
; 15(4): 169-87, 2004 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-15457679
18.
Attempt to reduce cytotoxicity by synthesizing the L-enantiomer of 4'-C-ethynyl-2'-deoxypurine nucleosides as antiviral agents against HIV and HBV.
Antivir Chem Chemother
; 15(3): 161-7, 2004 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15266898
19.
Synthesis of 4'-C-ethynyl and 4'-C-cyano purine nucleosides from natural nucleosides and their anti-HIV activity.
Nucleosides Nucleotides Nucleic Acids
; 22(5-8): 887-9, 2003.
Artigo
em Inglês
| MEDLINE | ID: mdl-14565303
20.
Design, efficient synthesis, and anti-HIV activity of 4'-C-cyano- and 4'-C-ethynyl-2'-deoxy purine nucleosides.
Nucleosides Nucleotides Nucleic Acids
; 23(4): 671-90, 2004.
Artigo
em Inglês
| MEDLINE | ID: mdl-15200030