Detalhe da pesquisa
1.
TAK-994, a Novel Orally Available Brain-Penetrant Orexin 2 Receptor-Selective Agonist, Suppresses Fragmentation of Wakefulness and Cataplexy-Like Episodes in Mouse Models of Narcolepsy.
J Pharmacol Exp Ther
; 385(3): 193-204, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37001988
2.
Preclinical characterization of [18F]T-008, a novel PET imaging radioligand for cholesterol 24-hydroxylase.
Eur J Nucl Med Mol Imaging
; 49(4): 1148-1156, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34651220
3.
Discovery of novel 4-phenyl-2-(pyrrolidinyl)nicotinamide derivatives as potent Nav1.1 activators.
Bioorg Med Chem Lett
; 29(6): 815-820, 2019 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30704812
4.
Discovery of novel 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine derivatives as γ-secretase modulators (Part 2).
Bioorg Med Chem
; 24(14): 3192-206, 2016 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27255179
5.
Discovery of novel 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine derivatives as γ-secretase modulators.
Bioorg Med Chem Lett
; 25(19): 4245-9, 2015 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26298496
6.
Design and synthesis of piperazine derivatives as a novel class of γ-secretase modulators that selectively lower Aß42 production.
Bioorg Med Chem
; 23(9): 1923-34, 2015 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25842363
7.
Pharmacological characterization of a highly selective and potent partial agonist of the MT2 melatonin receptor.
Pharmacology
; 93(5-6): 244-52, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25059758
8.
Deep learning for hetero-homo conversion in channel-domain for phase aberration correction in ultrasound imaging.
Ultrasonics
; 129: 106890, 2023 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-36462461
9.
Deep Learning-Based Seminal Vesicle and Vas Deferens Recognition in the Posterior Approach of Robot-Assisted Radical Prostatectomy.
Urology
; 173: 98-103, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36572225
10.
Discovery of Novel 3-Piperidinyl Pyridine Derivatives as Highly Potent and Selective Cholesterol 24-Hydroxylase (CH24H) Inhibitors.
J Med Chem
; 65(4): 3343-3358, 2022 02 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35166541
11.
Quantification of monoacylglycerol lipase and its occupancy by an exogenous ligand in rhesus monkey brains using [18F]T-401 and PET.
J Cereb Blood Flow Metab
; 42(4): 656-666, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34727758
12.
Molecular mechanism of the wake-promoting agent TAK-925.
Nat Commun
; 13(1): 2902, 2022 05 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-35614071
13.
Design and synthesis of aryl-piperidine derivatives as potent and selective PET tracers for cholesterol 24-hydroxylase (CH24H).
Eur J Med Chem
; 240: 114612, 2022 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35863274
14.
Discovery of a Novel and Brain-Penetrant O-GlcNAcase Inhibitor via Virtual Screening, Structure-Based Analysis, and Rational Lead Optimization.
J Med Chem
; 64(2): 1103-1115, 2021 01 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-33404239
15.
Synthesis of low-molecular weight fucoidan derivatives and their binding abilities to SARS-CoV-2 spike proteins.
RSC Med Chem
; 12(12): 2016-2021, 2021 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35028561
16.
Discovery of a Potent and Orally Bioavailable Melatonin Receptor Agonist.
J Med Chem
; 64(6): 3059-3074, 2021 03 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33682410
17.
Design, Synthesis, and Evaluation of 11C-Labeled 3-Acetyl-Indole Derivatives as a Novel Positron Emission Tomography Imaging Agent for Diacylglycerol Kinase Gamma (DGKγ) in Brain.
J Med Chem
; 64(16): 11990-12002, 2021 08 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-34347478
18.
Design, Synthesis, and Evaluation of [18F]T-914 as a Novel Positron-Emission Tomography Tracer for Lysine-Specific Demethylase 1.
J Med Chem
; 64(17): 12680-12690, 2021 09 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34423983
19.
Discovery of Soticlestat, a Potent and Selective Inhibitor for Cholesterol 24-Hydroxylase (CH24H).
J Med Chem
; 64(16): 12228-12244, 2021 08 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-34387987
20.
Design, Synthesis, and Evaluation of (2-Aminocyclopropyl)phenyl Derivatives as Novel Positron Emission Tomography Imaging Agents for Lysine-Specific Demethylase 1 in the Brain.
J Med Chem
; 64(7): 3780-3793, 2021 04 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33729758