Detalhe da pesquisa
1.
PHASE 2 RANDOMIZED STUDY (ORION-1) OF A NOVEL, BIODEGRADABLE DEXAMETHASONE IMPLANT (AR-1105) FOR THE TREATMENT OF MACULAR EDEMA DUE TO CENTRAL OR BRANCH RETINAL VEIN OCCLUSION.
Retina
; 43(1): 25-33, 2023 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36542081
2.
Consensus recommendations for trabecular meshwork cell isolation, characterization and culture.
Exp Eye Res
; 171: 164-173, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29526795
3.
Role of the Rho GTPase/Rho kinase signaling pathway in pathogenesis and treatment of glaucoma: Bench to bedside research.
Exp Eye Res
; 158: 23-32, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27593914
4.
Discovery of the ROCK inhibitor netarsudil for the treatment of open-angle glaucoma.
Bioorg Med Chem Lett
; 26(10): 2475-2480, 2016 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27072905
5.
Double-masked, randomized, dose-response study of AR-13324 versus latanoprost in patients with elevated intraocular pressure.
Ophthalmology
; 122(2): 302-7, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25270273
6.
Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genome.
Nat Genet
; 36(3): 288-92, 2004 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-14981519
7.
A complementary transposon tool kit for Drosophila melanogaster using P and piggyBac.
Nat Genet
; 36(3): 283-7, 2004 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-14981521
8.
Rho Kinase Inhibitor AR-12286 Reverses Steroid-Induced Changes in Intraocular Pressure, Effective Filtration Areas, and Morphology in Mouse Eyes.
Invest Ophthalmol Vis Sci
; 64(2): 7, 2023 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36734964
9.
Phase 3 Clinical Trial Comparing the Safety and Efficacy of Netarsudil to Ripasudil in Patients with Primary Open-Angle Glaucoma or Ocular Hypertension: Japan Rho Kinase Elevated Intraocular Pressure Treatment Trial (J-ROCKET).
Adv Ther
; 40(10): 4639-4656, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37603205
10.
Discovery and Preclinical Development of Novel Intraocular Pressure-Lowering Rho Kinase Inhibitor: Corticosteroid Conjugates.
J Ocul Pharmacol Ther
; 39(2): 117-127, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36602977
11.
Eyes on Topical Ocular Disposition: The Considered Design of a Lead Janus Kinase (JAK) Inhibitor That Utilizes a Unique Azetidin-3-Amino Bridging Scaffold to Attenuate Off-Target Kinase Activity, While Driving Potency and Aqueous Solubility.
J Med Chem
; 66(13): 8929-8950, 2023 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37314941
12.
A Randomized, Phase 2 Study of 24-h Efficacy and Tolerability of Netarsudil in Ocular Hypertension and Open-Angle Glaucoma.
Ophthalmol Ther
; 10(1): 89-100, 2021 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-33244711
13.
Phase 2 Randomized Clinical Study of Netarsudil Ophthalmic Solution in Japanese Patients with Primary Open-Angle Glaucoma or Ocular Hypertension.
Adv Ther
; 38(4): 1757-1775, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33629227
14.
Netarsudil Improves Trabecular Outflow Facility in Patients with Primary Open Angle Glaucoma or Ocular Hypertension: A Phase 2 Study.
Am J Ophthalmol
; 226: 262-269, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33524367
15.
Anti-fibrotic activity of a rho-kinase inhibitor restores outflow function and intraocular pressure homeostasis.
Elife
; 102021 03 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-33783352
16.
Effects of Netarsudil on Actin-Driven Cellular Functions in Normal and Glaucomatous Trabecular Meshwork Cells: A Live Imaging Study.
J Clin Med
; 9(11)2020 Oct 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-33142742
17.
One Year of Netarsudil and Latanoprost Fixed-Dose Combination for Elevated Intraocular Pressure: Phase 3, Randomized MERCURY-1 Study.
Ophthalmol Glaucoma
; 3(5): 327-338, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32768361
18.
Fixed-Dose Combination of Netarsudil and Latanoprost in Ocular Hypertension and Open-Angle Glaucoma: Pooled Efficacy/Safety Analysis of Phase 3 MERCURY-1 and -2.
Adv Ther
; 37(4): 1620-1631, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32166538
19.
Pooled Efficacy and Safety Profile of Netarsudil Ophthalmic Solution 0.02% in Patients With Open-angle Glaucoma or Ocular Hypertension.
J Glaucoma
; 29(10): 878-884, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32826769
20.
Once-Daily Netarsudil/Latanoprost Fixed-Dose Combination for Elevated Intraocular Pressure in the Randomized Phase 3 MERCURY-2 Study.
Ophthalmol Glaucoma
; 2(5): 280-289, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-32672669