Detalhe da pesquisa
1.
SARS-CoV-2 targets neurons of 3D human brain organoids.
EMBO J
; 39(20): e106230, 2020 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32876341
2.
Disruption of cellular proteostasis by H1N1 influenza A virus causes α-synuclein aggregation.
Proc Natl Acad Sci U S A
; 117(12): 6741-6751, 2020 03 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32152117
3.
Disrupted-in-schizophrenia 1 protein aggregates in cerebrospinal fluid are elevated in patients with first-episode psychosis.
Psychiatry Clin Neurosci
; 77(12): 665-671, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37668563
4.
TRIOBP-1 Protein Aggregation Exists in Both Major Depressive Disorder and Schizophrenia, and Can Occur through Two Distinct Regions of the Protein.
Int J Mol Sci
; 23(19)2022 Sep 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36232351
5.
The interaction of insoluble Amyloid-ß with soluble Amyloid-ß dimers decreases Amyloid-ß plaque numbers.
Neuropathol Appl Neurobiol
; 47(5): 603-610, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33338256
6.
The effect of the DISC1 Ser704Cys polymorphism on striatal dopamine synthesis capacity: an [18F]-DOPA PET study.
Hum Mol Genet
; 27(20): 3498-3506, 2018 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29945223
7.
Protein misassembly and aggregation as potential convergence points for non-genetic causes of chronic mental illness.
Mol Psychiatry
; 24(7): 936-951, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30089789
8.
IPSC-Derived Neuronal Cultures Carrying the Alzheimer's Disease Associated TREM2 R47H Variant Enables the Construction of an Aß-Induced Gene Regulatory Network.
Int J Mol Sci
; 21(12)2020 Jun 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32630447
9.
Tools as "petrified memes": A duality.
Behav Brain Sci
; 43: e169, 2020 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32772976
10.
Disrupted-in-schizophrenia 1 overexpression disrupts hippocampal coding and oscillatory synchronization.
Hippocampus
; 29(9): 802-816, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30723982
11.
An unpredicted aggregation-critical region of the actin-polymerizing protein TRIOBP-1/Tara, determined by elucidation of its domain structure.
J Biol Chem
; 292(23): 9583-9598, 2017 06 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28438837
12.
A structural organization for the Disrupted in Schizophrenia 1 protein, identified by high-throughput screening, reveals distinctly folded regions, which are bisected by mental illness-related mutations.
J Biol Chem
; 292(16): 6468-6477, 2017 04 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-28249940
13.
Soluble amyloid-ß dimers are resistant to amyloid-ß prion conversion in vivo suggesting antiprion properties.
Neuropathol Appl Neurobiol
; 49(2): e12895, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36861420
14.
Behavioral Resilience and Sensitivity to Locally Restricted Cortical Migration Deficits Induced by In Utero Knockdown of Disabled-1 in the Adult Rat.
Cereb Cortex
; 27(3): 2052-2063, 2017 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26965907
15.
Proteomic Studies Reveal Disrupted in Schizophrenia 1 as a Player in Both Neurodevelopment and Synaptic Function.
Int J Mol Sci
; 20(1)2018 12 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-30597994
16.
DISC1-dependent Regulation of Mitochondrial Dynamics Controls the Morphogenesis of Complex Neuronal Dendrites.
J Biol Chem
; 291(2): 613-29, 2016 Jan 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26553875
17.
Intra-nasal dopamine alleviates cognitive deficits in tgDISC1 rats which overexpress the human DISC1 gene.
Neurobiol Learn Mem
; 146: 12-20, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-29107702
18.
Amyloid-ß dimers in the absence of plaque pathology impair learning and synaptic plasticity.
Brain
; 139(Pt 2): 509-25, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26657517
19.
Neuropeptide precursor VGF is genetically associated with social anhedonia and underrepresented in the brain of major mental illness: its downregulation by DISC1.
Hum Mol Genet
; 23(22): 5859-65, 2014 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24934694
20.
DISC1 regulates expression of the neurotrophin VGF through the PI3K/AKT/CREB pathway.
J Neurochem
; 135(3): 598-605, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26212236