Detalhe da pesquisa
1.
Establishing the Safe Space via Physiologically Based Biopharmaceutics Modeling. Case Study: Fevipiprant/QAW039.
AAPS J
; 25(1): 25, 2023 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36788163
2.
Usefulness of the BioGIT system in screening for differences in early exposure in the fasted state on an a priori basis.
Int J Pharm
; 634: 122670, 2023 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36736968
3.
Screening for Differences in Early Exposure in the Fasted State with in Vitro Methodologies can be Challenging: Experience with the BioGIT System.
J Pharm Sci
; 112(8): 2240-2248, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36918113
4.
Simulation of Intraluminal Performance of Lipophilic Weak Bases in Fasted Healthy Adults Using DDDPlusTM.
AAPS J
; 24(5): 89, 2022 08 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-35974242
5.
Physiologically Based Pharmacokinetic Modeling of Oral Absorption, pH, and Food Effect in Healthy Volunteers to Drive Alpelisib Formulation Selection.
AAPS J
; 22(6): 134, 2020 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33070288
6.
The effect of reduced gastric acid secretion on the gastrointestinal disposition of a ritonavir amorphous solid dispersion in fasted healthy volunteers: an in vivo - in vitro investigation.
Eur J Pharm Sci
; 151: 105377, 2020 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32461076
7.
The BioGIT System: a Valuable In Vitro Tool to Assess the Impact of Dose and Formulation on Early Exposure to Low Solubility Drugs After Oral Administration.
AAPS J
; 20(4): 71, 2018 05 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-29797293
8.
Evaluation of the Impact of Excipients and an Albendazole Salt on Albendazole Concentrations in Upper Small Intestine Using an In Vitro Biorelevant Gastrointestinal Transfer (BioGIT) System.
J Pharm Sci
; 105(9): 2896-2903, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27372549
9.
Effectiveness of supersaturation promoting excipients on albendazole concentrations in upper gastrointestinal lumen of fasted healthy adults.
Eur J Pharm Sci
; 91: 11-9, 2016 Aug 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-27185297
10.
An in vitro biorelevant gastrointestinal transfer (BioGIT) system for forecasting concentrations in the fasted upper small intestine: Design, implementation, and evaluation.
Eur J Pharm Sci
; 82: 106-14, 2016 Jan 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-26594026
11.
In vitro evaluation of the impact of gastrointestinal transfer on luminal performance of commercially available products of posaconazole and itraconazole using BioGIT.
Int J Pharm
; 515(1-2): 352-358, 2016 Dec 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-27732895