Detalhe da pesquisa
1.
Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency.
Mol Cell
; 81(15): 3128-3144.e7, 2021 08 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34216544
2.
ATF3 coordinates serine and nucleotide metabolism to drive cell cycle progression in acute myeloid leukemia.
Mol Cell
; 81(13): 2752-2764.e6, 2021 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34081901
3.
Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency.
Mol Cell
; 81(15): 3227, 2021 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34358459
4.
Ectopic RNF168 expression promotes break-induced replication-like DNA synthesis at stalled replication forks.
Nucleic Acids Res
; 48(8): 4298-4308, 2020 05 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32182354
5.
Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors.
Nat Commun
; 15(1): 2862, 2024 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38580648
6.
Antitumor activity of an enzyme prodrug therapy targeted to the breast tumor vasculature.
Cancer Invest
; 31(8): 505-10, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-24083814
7.
Targeting single-walled carbon nanotubes for the treatment of breast cancer using photothermal therapy.
Nanotechnology
; 24(37): 375104, 2013 Sep 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-23975064
8.
Genetic separation of Brca1 functions reveal mutation-dependent Polθ vulnerabilities.
Nat Commun
; 14(1): 7714, 2023 Nov 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-38001070
9.
BRCA1 secondary splice-site mutations drive exon-skipping and PARP inhibitor resistance.
medRxiv
; 2023 Aug 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36993400
10.
4'-Ethynyl-2'-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress.
Mol Cancer Ther
; 2023 Dec 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38064712
11.
RNF168-mediated localization of BARD1 recruits the BRCA1-PALB2 complex to DNA damage.
Nat Commun
; 12(1): 5016, 2021 08 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34408138
12.
Replication Gaps Underlie BRCA Deficiency and Therapy Response.
Cancer Res
; 81(5): 1388-1397, 2021 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33184108
13.
BRCA1 Mutations in Cancer: Coordinating Deficiencies in Homologous Recombination with Tumorigenesis.
Cancer Res
; 80(21): 4601-4609, 2020 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32747362
14.
RNF168-Mediated Ubiquitin Signaling Inhibits the Viability of BRCA1-Null Cancers.
Cancer Res
; 80(13): 2848-2860, 2020 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32213544
15.
Targeted blockade of HSP90 impairs DNA-damage response proteins and increases the sensitivity of ovarian carcinoma cells to PARP inhibition.
Cancer Biol Ther
; 20(7): 1035-1045, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30929564
16.
BRCA1 intronic Alu elements drive gene rearrangements and PARP inhibitor resistance.
Nat Commun
; 10(1): 5661, 2019 12 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31827092
17.
BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance.
Cell Rep
; 24(13): 3513-3527.e7, 2018 09 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-30257212
18.
Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma.
Nat Commun
; 9(1): 3970, 2018 09 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-30266954
19.
Antitumor Synergism and Enhanced Survival with a Tumor Vasculature-Targeted Enzyme Prodrug System, Rapamycin, and Cyclophosphamide.
Mol Cancer Ther
; 16(9): 1855-1865, 2017 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28522586
20.
RING domain-deficient BRCA1 promotes PARP inhibitor and platinum resistance.
J Clin Invest
; 126(8): 3145-57, 2016 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27454289