Detalhe da pesquisa
1.
2,6-Disubstituted pyrazines and related analogs as NR2B site antagonists of the NMDA receptor with anti-depressant activity.
Bioorg Med Chem Lett
; 21(11): 3399-403, 2011 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21524576
2.
Application of fragment-based lead generation to the discovery of novel, cyclic amidine beta-secretase inhibitors with nanomolar potency, cellular activity, and high ligand efficiency.
J Med Chem
; 50(24): 5912-25, 2007 Nov 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-17985862
3.
Statistical tools for virtual screening.
J Med Chem
; 48(23): 7477-81, 2005 Nov 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-16279807
4.
Small molecule affinity fingerprinting. A tool for enzyme family subclassification, target identification, and inhibitor design.
Chem Biol
; 9(10): 1085-94, 2002 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-12401493
5.
Calculation and application of activity discriminants in lead optimization.
J Mol Graph Model
; 29(3): 372-81, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20800520
6.
De novo design of a picomolar nonbasic 5-HT(1B) receptor antagonist.
J Med Chem
; 53(4): 1876-80, 2010 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-20088516