Detalhe da pesquisa
1.
Heterocycle amide isosteres: An approach to overcoming resistance for HIV-1 integrase strand transfer inhibitors.
Bioorg Med Chem Lett
; 30(3): 126784, 2020 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31761656
2.
Structure-based amelioration of PXR transactivation in a novel series of macrocyclic allosteric inhibitors of HIV-1 integrase.
Bioorg Med Chem Lett
; 30(22): 127531, 2020 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32890685
3.
The discovery and preclinical evaluation of BMS-707035, a potent HIV-1 integrase strand transfer inhibitor.
Bioorg Med Chem Lett
; 28(12): 2124-2130, 2018 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29779976
4.
(Carbonyl)oxyalkyl linker-based amino acid prodrugs of the HIV-1 protease inhibitor atazanavir that enhance oral bioavailability and plasma trough concentration.
Eur J Med Chem
; 207: 112749, 2020 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33065417
5.
Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV-1 Integrase Inhibitors.
J Med Chem
; 63(5): 2620-2637, 2020 03 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32081010
6.
Design, Synthesis, and Pharmacokinetic Evaluation of Phosphate and Amino Acid Ester Prodrugs for Improving the Oral Bioavailability of the HIV-1 Protease Inhibitor Atazanavir.
J Med Chem
; 62(7): 3553-3574, 2019 04 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30938524
7.
The terminal (catalytic) adenosine of the HIV LTR controls the kinetics of binding and dissociation of HIV integrase strand transfer inhibitors.
Biochemistry
; 47(51): 13481-8, 2008 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-18991395
8.
Inhibitors of HIV-1 Attachment: The Discovery and Development of Temsavir and its Prodrug Fostemsavir.
J Med Chem
; 61(1): 62-80, 2018 01 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-29271653
9.
Coupling of an Acyl Migration Prodrug Strategy with Bio-activation To Improve Oral Delivery of the HIV-1 Protease Inhibitor Atazanavir.
J Med Chem
; 61(9): 4176-4188, 2018 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29693401
10.
Biochemical analysis of HIV-1 integrase variants resistant to strand transfer inhibitors.
J Biol Chem
; 283(35): 23599-609, 2008 Aug 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-18577511
11.
Influenza--the case for combination therapy.
Curr Opin Investig Drugs
; 10(8): 746-9, 2009 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-19649919