The presence of Y chromosome leads to the difference of cancer in patients with different sexes.

(A) In the case of LOY, the proportion of T cells and suppressor macrophages rises and T cells enhance the expression of TOX, eventually leading to the metastasis of the tumor. (B) KRASmut enhances the gene expression of KDM5D, leading to a decreased expression of the AMOT and TAP1/2 downstream of KDM5D. Thereby, the cell-cell junction and antigen presentation are affected. All elements in Figure 1 are original .