Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

Diverse mechanisms of somatic structural variations in human cancer genomes.

Yang, Lixing; Luquette, Lovelace J; Gehlenborg, Nils; Xi, Ruibin; Haseley, Psalm S; Hsieh, Chih-Heng; Zhang, Chengsheng; Ren, Xiaojia; Protopopov, Alexei; Chin, Lynda; Kucherlapati, Raju; Lee, Charles; Park, Peter J.

Cell ; 153(4): 919-29, 2013 May 09.

Artigo em Inglês | MEDLINE | ID: mdl-23663786

2.

The somatic genomic landscape of glioblastoma.

Brennan, Cameron W; Verhaak, Roel G W; McKenna, Aaron; Campos, Benito; Noushmehr, Houtan; Salama, Sofie R; Zheng, Siyuan; Chakravarty, Debyani; Sanborn, J Zachary; Berman, Samuel H; Beroukhim, Rameen; Bernard, Brady; Wu, Chang-Jiun; Genovese, Giannicola; Shmulevich, Ilya; Barnholtz-Sloan, Jill; Zou, Lihua; Vegesna, Rahulsimham; Shukla, Sachet A; Ciriello, Giovanni; Yung, W K; Zhang, Wei; Sougnez, Carrie; Mikkelsen, Tom; Aldape, Kenneth; Bigner, Darell D; Van Meir, Erwin G; Prados, Michael; Sloan, Andrew; Black, Keith L; Eschbacher, Jennifer; Finocchiaro, Gaetano; Friedman, William; Andrews, David W; Guha, Abhijit; Iacocca, Mary; O'Neill, Brian P; Foltz, Greg; Myers, Jerome; Weisenberger, Daniel J; Penny, Robert; Kucherlapati, Raju; Perou, Charles M; Hayes, D Neil; Gibbs, Richard; Marra, Marco; Mills, Gordon B; Lander, Eric; Spellman, Paul; Wilson, Richard.

Cell ; 155(2): 462-77, 2013 Oct 10.

Artigo em Inglês | MEDLINE | ID: mdl-24120142

3.

Analyzing Somatic Genome Rearrangements in Human Cancers by Using Whole-Exome Sequencing.

Yang, Lixing; Lee, Mi-Sook; Lu, Hengyu; Oh, Doo-Yi; Kim, Yeon Jeong; Park, Donghyun; Park, Gahee; Ren, Xiaojia; Bristow, Christopher A; Haseley, Psalm S; Lee, Soohyun; Pantazi, Angeliki; Kucherlapati, Raju; Park, Woong-Yang; Scott, Kenneth L; Choi, Yoon-La; Park, Peter J.

Am J Hum Genet ; 98(5): 843-856, 2016 05 05.

Artigo em Inglês | MEDLINE | ID: mdl-27153396

4.

Integrated genomic characterization of endometrial carcinoma.

Kandoth, Cyriac; Schultz, Nikolaus; Cherniack, Andrew D; Akbani, Rehan; Liu, Yuexin; Shen, Hui; Robertson, A Gordon; Pashtan, Itai; Shen, Ronglai; Benz, Christopher C; Yau, Christina; Laird, Peter W; Ding, Li; Zhang, Wei; Mills, Gordon B; Kucherlapati, Raju; Mardis, Elaine R; Levine, Douglas A.

Nature ; 497(7447): 67-73, 2013 May 02.

Artigo em Inglês | MEDLINE | ID: mdl-23636398

5.

MIIP haploinsufficiency induces chromosomal instability and promotes tumour progression in colorectal cancer.

Sun, Yan; Ji, Ping; Chen, Tao; Zhou, Xinhui; Yang, Da; Guo, Yuhong; Liu, Yuexin; Hu, Limei; Xia, Dianren; Liu, Yanxue; Multani, Asha S; Shmulevich, Ilya; Kucherlapati, Raju; Kopetz, Scott; Sood, Anil K; Hamilton, Stanley R; Sun, Baocun; Zhang, Wei.

J Pathol ; 241(1): 67-79, 2017 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-27741356

6.

Oliver Smithies (1925-2017).

Kucherlapati, Raju.

Nature ; 542(7640): 166, 2017 02 08.

Artigo em Inglês | MEDLINE | ID: mdl-28179651

7.

Next-generation sequencing identifies rare variants associated with Noonan syndrome.

Chen, Peng-Chieh; Yin, Jiani; Yu, Hui-Wen; Yuan, Tao; Fernandez, Minerva; Yung, Christina K; Trinh, Quang M; Peltekova, Vanya D; Reid, Jeffrey G; Tworog-Dube, Erica; Morgan, Margaret B; Muzny, Donna M; Stein, Lincoln; McPherson, John D; Roberts, Amy E; Gibbs, Richard A; Neel, Benjamin G; Kucherlapati, Raju.

Proc Natl Acad Sci U S A ; 111(31): 11473-8, 2014 Aug 05.

Artigo em Inglês | MEDLINE | ID: mdl-25049390

8.

Characterization of HPV and host genome interactions in primary head and neck cancers.

Parfenov, Michael; Pedamallu, Chandra Sekhar; Gehlenborg, Nils; Freeman, Samuel S; Danilova, Ludmila; Bristow, Christopher A; Lee, Semin; Hadjipanayis, Angela G; Ivanova, Elena V; Wilkerson, Matthew D; Protopopov, Alexei; Yang, Lixing; Seth, Sahil; Song, Xingzhi; Tang, Jiabin; Ren, Xiaojia; Zhang, Jianhua; Pantazi, Angeliki; Santoso, Netty; Xu, Andrew W; Mahadeshwar, Harshad; Wheeler, David A; Haddad, Robert I; Jung, Joonil; Ojesina, Akinyemi I; Issaeva, Natalia; Yarbrough, Wendell G; Hayes, D Neil; Grandis, Jennifer R; El-Naggar, Adel K; Meyerson, Matthew; Park, Peter J; Chin, Lynda; Seidman, J G; Hammerman, Peter S; Kucherlapati, Raju.

Proc Natl Acad Sci U S A ; 111(43): 15544-9, 2014 Oct 28.

Artigo em Inglês | MEDLINE | ID: mdl-25313082

9.

Germline gain-of-function mutations in SOS1 cause Noonan syndrome.

Roberts, Amy E; Araki, Toshiyuki; Swanson, Kenneth D; Montgomery, Kate T; Schiripo, Taryn A; Joshi, Victoria A; Li, Li; Yassin, Yosuf; Tamburino, Alex M; Neel, Benjamin G; Kucherlapati, Raju S.

Nat Genet ; 39(1): 70-4, 2007 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-17143285

10.

Spectrum of somatic mitochondrial mutations in five cancers.

Larman, Tatianna C; DePalma, Steven R; Hadjipanayis, Angela G; Protopopov, Alexei; Zhang, Jianhua; Gabriel, Stacey B; Chin, Lynda; Seidman, Christine E; Kucherlapati, Raju; Seidman, J G.

Proc Natl Acad Sci U S A ; 109(35): 14087-91, 2012 Aug 28.

Artigo em Inglês | MEDLINE | ID: mdl-22891333

11.

Apc deficiency alters pulmonary epithelial cell fate and inhibits Nkx2.1 via triggering TGF-beta signaling.

Li, Changgong; Li, Aimin; Xing, Yiming; Li, Min; Chan, Belinda; Ouyang, Ruoyun; Taketo, Makoto Mark; Kucherlapati, Raju; Borok, Zea; Minoo, Parviz.

Dev Biol ; 378(1): 13-24, 2013 Jun 01.

Artigo em Inglês | MEDLINE | ID: mdl-23562608

12.

Impaired lymphatic contraction associated with immunosuppression.

Liao, Shan; Cheng, Gang; Conner, David A; Huang, Yuhui; Kucherlapati, Raju S; Munn, Lance L; Ruddle, Nancy H; Jain, Rakesh K; Fukumura, Dai; Padera, Timothy P.

Proc Natl Acad Sci U S A ; 108(46): 18784-9, 2011 Nov 15.

Artigo em Inglês | MEDLINE | ID: mdl-22065738

13.

Copy number variation detection in whole-genome sequencing data using the Bayesian information criterion.

Xi, Ruibin; Hadjipanayis, Angela G; Luquette, Lovelace J; Kim, Tae-Min; Lee, Eunjung; Zhang, Jianhua; Johnson, Mark D; Muzny, Donna M; Wheeler, David A; Gibbs, Richard A; Kucherlapati, Raju; Park, Peter J.

Proc Natl Acad Sci U S A ; 108(46): E1128-36, 2011 Nov 15.

Artigo em Inglês | MEDLINE | ID: mdl-22065754

14.

Mutation in Rpa1 results in defective DNA double-strand break repair, chromosomal instability and cancer in mice.

Wang, Yuxun; Putnam, Christopher D; Kane, Michael F; Zhang, Weijia; Edelmann, Lisa; Russell, Robert; Carrión, Danaise V; Chin, Lynda; Kucherlapati, Raju; Kolodner, Richard D; Edelmann, Winfried.

Nat Genet ; 37(7): 750-5, 2005 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-15965476

15.

Tbx1: identification of a 22q11.2 gene as a risk factor for autism spectrum disorder in a mouse model.

Hiramoto, Takeshi; Kang, Gina; Suzuki, Go; Satoh, Yasushi; Kucherlapati, Raju; Watanabe, Yasuhiro; Hiroi, Noboru.

Hum Mol Genet ; 20(24): 4775-85, 2011 Dec 15.

Artigo em Inglês | MEDLINE | ID: mdl-21908517

16.

A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease.

McDonald, David A; Shenkar, Robert; Shi, Changbin; Stockton, Rebecca A; Akers, Amy L; Kucherlapati, Melanie H; Kucherlapati, Raju; Brainer, James; Ginsberg, Mark H; Awad, Issam A; Marchuk, Douglas A.

Hum Mol Genet ; 20(2): 211-22, 2011 Jan 15.

Artigo em Inglês | MEDLINE | ID: mdl-20940147

17.

In vivo wide-area cellular imaging by side-view endomicroscopy.

Kim, Pilhan; Chung, Euiheon; Yamashita, Hiroshi; Hung, Kenneth E; Mizoguchi, Atsushi; Kucherlapati, Raju; Fukumura, Dai; Jain, Rakesh K; Yun, Seok H.

Nat Methods ; 7(4): 303-5, 2010 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-20228814

18.

Cis lethal genetic interactions attenuate and alter p53 tumorigenesis.

Wang, Yuxun; Zhang, Weijia; Edelmann, Lisa; Kolodner, Richard D; Kucherlapati, Raju; Edelmann, Winfried.

Proc Natl Acad Sci U S A ; 107(12): 5511-5, 2010 Mar 23.

Artigo em Inglês | MEDLINE | ID: mdl-20212136

19.

Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment.

Hung, Kenneth E; Maricevich, Marco A; Richard, Larissa Georgeon; Chen, Wei Y; Richardson, Michael P; Kunin, Alexandra; Bronson, Roderick T; Mahmood, Umar; Kucherlapati, Raju.

Proc Natl Acad Sci U S A ; 107(4): 1565-70, 2010 Jan 26.

Artigo em Inglês | MEDLINE | ID: mdl-20080688

20.

In vivo optical molecular imaging of matrix metalloproteinase activity following celecoxib therapy for colorectal cancer.

Sheth, Rahul A; Kunin, Alexandra; Stangenberg, Lars; Sinnamon, Mark; Hung, Kenneth E; Kucherlapati, Raju; Mahmood, Umar.

Mol Imaging ; 11(5): 417-25, 2012.

Artigo em Inglês | MEDLINE | ID: mdl-22954186

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