Detalhe da pesquisa
1.
Structural Basis for Allosteric Ligand Recognition in the Human CC Chemokine Receptor 7.
Cell
; 178(5): 1222-1230.e10, 2019 08 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-31442409
2.
A potent seven-membered cyclic BTK (Bruton's tyrosine Kinase) chiral inhibitor conceived by structure-based drug design to lock its bioactive conformation.
Bioorg Med Chem Lett
; 29(9): 1074-1078, 2019 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30857747
3.
Water molecules in protein-ligand interfaces. Evaluation of software tools and SAR comparison.
J Comput Aided Mol Des
; 33(3): 307-330, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30756207
4.
Finding the perfect spot for fluorine: improving potency up to 40-fold during a rational fluorine scan of a Bruton's Tyrosine Kinase (BTK) inhibitor scaffold.
Bioorg Med Chem Lett
; 25(2): 367-71, 2015 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25466710
5.
Scaffold hopping towards potent and selective JAK3 inhibitors: discovery of novel C-5 substituted pyrrolopyrazines.
Bioorg Med Chem Lett
; 24(21): 4969-75, 2014 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25262541
6.
The structure of XIAP BIR2: understanding the selectivity of the BIR domains.
Acta Crystallogr D Biol Crystallogr
; 69(Pt 9): 1717-25, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23999295
7.
Mapping the conformational space accessible to BACE2 using surface mutants and cocrystals with Fab fragments, Fynomers and Xaperones.
Acta Crystallogr D Biol Crystallogr
; 69(Pt 6): 1124-37, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23695257
8.
Discovery of a series of novel 5H-pyrrolo[2,3-b]pyrazine-2-phenyl ethers, as potent JAK3 kinase inhibitors.
Bioorg Med Chem Lett
; 23(9): 2522-6, 2013 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23541670
9.
Strategic use of conformational bias and structure based design to identify potent JAK3 inhibitors with improved selectivity against the JAK family and the kinome.
Bioorg Med Chem Lett
; 23(9): 2793-800, 2013 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23540648
10.
Development of indole/indazole-aminopyrimidines as inhibitors of c-Jun N-terminal kinase (JNK): optimization for JNK potency and physicochemical properties.
Bioorg Med Chem Lett
; 23(12): 3565-9, 2013 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23664880
11.
Development of amino-pyrimidine inhibitors of c-Jun N-terminal kinase (JNK): kinase profiling guided optimization of a 1,2,3-benzotriazole lead.
Bioorg Med Chem Lett
; 23(5): 1486-92, 2013 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23352510
12.
Nanolitre-scale crystallization using acoustic liquid-transfer technology.
Acta Crystallogr D Biol Crystallogr
; 68(Pt 8): 893-900, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22868754
13.
Discovery of a novel series of 4-quinolone JNK inhibitors.
Bioorg Med Chem Lett
; 22(24): 7381-7, 2012 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23142618
14.
Discovery of Novel Allosteric EGFR L858R Inhibitors for the Treatment of Non-Small-Cell Lung Cancer as a Single Agent or in Combination with Osimertinib.
J Med Chem
; 65(19): 13052-13073, 2022 10 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36178776
15.
Structural basis for the cyclophilin A binding affinity and immunosuppressive potency of E-ISA247 (voclosporin).
Acta Crystallogr D Biol Crystallogr
; 67(Pt 2): 119-23, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21245533
16.
3-Amino-pyrazolo[3,4-d]pyrimidines as p38α kinase inhibitors: design and development to a highly selective lead.
Bioorg Med Chem Lett
; 21(11): 3452-6, 2011 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21515047
17.
Acoustic matrix microseeding: improving protein crystal growth with minimal chemical bias.
Acta Crystallogr D Biol Crystallogr
; 66(Pt 5): 568-76, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20445232
18.
X-ray crystal structure of JNK2 complexed with the p38alpha inhibitor BIRB796: insights into the rational design of DFG-out binding MAP kinase inhibitors.
Bioorg Med Chem Lett
; 20(17): 5217-20, 2010 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20655210
19.
Format chain exchange (FORCE) for high-throughput generation of bispecific antibodies in combinatorial binder-format matrices.
Nat Commun
; 11(1): 4974, 2020 10 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33009381
20.
Discovery of 3-Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors.
J Med Chem
; 63(13): 6876-6897, 2020 07 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32530624