Detalhe da pesquisa
1.
Discovery of ASP5878: Synthesis and structure-activity relationships of pyrimidine derivatives as pan-FGFRs inhibitors with improved metabolic stability and suppressed hERG channel inhibitory activity.
Bioorg Med Chem
; 59: 116657, 2022 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35219181
2.
Synthesis and structure-activity relationships of pyrimidine derivatives as potent and orally active FGFR3 inhibitors with both increased systemic exposure and enhanced in vitro potency.
Bioorg Med Chem
; 33: 116019, 2021 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33486159
3.
Structure-based drug design of 1,3,5-triazine and pyrimidine derivatives as novel FGFR3 inhibitors with high selectivity over VEGFR2.
Bioorg Med Chem
; 28(10): 115453, 2020 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32278710
4.
Highly regioselective nucleophilic carbon-carbon bond formation on furans and thiophenes initiated by pummerer-type reaction.
Org Lett
; 6(21): 3793-6, 2004 Oct 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-15469351
5.
Total synthesis of (+/-)-gamma-rubromycin on the basis of two aromatic Pummerer-type reactions.
Angew Chem Int Ed Engl
; 46(39): 7458-61, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17702074