RESUMO
OBJECTIVES: To evaluate complications, short- and medium-term outcomes following treatment of lameness associated with cranial cruciate ligament insufficiency in dogs using the "TTA-Rapid" technique. METHODS: Patient records from two veterinary clinics were retrospectively examined to collect data from cases treated over a period of 21 months. An owner postal questionnaire using a clinical metrology instrument (Liverpool Osteoarthritis in Dogs) evaluated medium-term outcome of at least six months. RESULTS: In total 152 procedures were carried out in 141 dogs by two surgeons. Major complications, requiring further intervention, were identified in 11 (7%). Nine of these involved "late" meniscal injuries and two sustained tibial fractures postoperatively, one requiring internal fixation and the other external coaptation. The 3-month outcome was considered satisfactory in 99% of 135 procedures whilst the medium-term outcome (mean 16 months) was considered satisfactory in 86% of 108 dogs. CLINICAL SIGNIFICANCE: "TTA-Rapid" offers a treatment option for cranial cruciate-deficient stifles with good short- and medium-term outcomes. The complication rate was low in our hands.
Assuntos
Ligamento Cruzado Anterior/cirurgia , Doenças do Cão/cirurgia , Coxeadura Animal/cirurgia , Osteotomia/veterinária , Joelho de Quadrúpedes/cirurgia , Animais , Ligamento Cruzado Anterior/diagnóstico por imagem , Cães , Feminino , Masculino , Osteotomia/métodos , Avaliação de Resultados em Cuidados de Saúde , Complicações Pós-Operatórias/veterinária , Radiografia/veterinária , Estudos Retrospectivos , Joelho de Quadrúpedes/diagnóstico por imagem , Joelho de Quadrúpedes/lesõesAssuntos
Ascomicetos/isolamento & purificação , Doenças do Gato/microbiologia , Micoses/veterinária , Pielonefrite/veterinária , Animais , Antifúngicos/uso terapêutico , Gatos , Itraconazol/uso terapêutico , Masculino , Micoses/tratamento farmacológico , Micoses/microbiologia , Pielonefrite/tratamento farmacológico , Pielonefrite/microbiologiaAssuntos
Cloranfenicol/farmacologia , Cianetos/farmacologia , Dinitrofenóis/farmacologia , Envelhecimento Eritrocítico , Eritrócitos/metabolismo , Fluoretos/farmacologia , Tri-Iodotironina/metabolismo , Animais , Permeabilidade da Membrana Celular/efeitos dos fármacos , Cromatografia em Papel , Técnicas In Vitro , Fenil-Hidrazinas , Coelhos , Reticulócitos/metabolismoAssuntos
Sítios de Ligação , Eritrócitos/metabolismo , Reticulócitos/metabolismo , Tiroxina/sangue , Tiroxina/metabolismo , Tri-Iodotironina/sangue , Tri-Iodotironina/metabolismo , Diferenciação Celular , Membrana Celular , Eritrócitos/citologia , Concentração de Íons de Hidrogênio , Isótopos de IodoRESUMO
Molecular structural characteristics of thyroid hormones which influence binding to the erythrocyte membranes were investigated by competitive binding experiments. The ability of thyroid hormone analogs to displace 131 I-L-thyroxine and 131 I-L-triiodothyronine from the membranes was considered evidence of their competitive binding. The diphenyl ether linkage (thyronine) was essential as compounds with a single aromatic ring were weakly competitive. The presence of three iodine atoms at 3, 5 and 3' positions on thyronine was optimal for maximal competitive binding. There was weak competitive binding of analogs if chlorine or bromine was substituted for iodine. The alanine side chain was required for optimal binding as N-acetyl-l-thyroxine and various deaminated analogs were poor competitors compared to T4 and T3. L-isomers of T4 and T3 showed greater competitive binding to erythrocyte membranes than the corresponding d-isomers.