Detalhe da pesquisa
1.
CD40 agonistic monoclonal antibody APX005M (sotigalimab) and chemotherapy, with or without nivolumab, for the treatment of metastatic pancreatic adenocarcinoma: an open-label, multicentre, phase 1b study.
Lancet Oncol
; 22(1): 118-131, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33387490
2.
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF.
Cancer Cell
; 3(4): 363-75, 2003 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-12726862
3.
Sotigalimab and/or nivolumab with chemotherapy in first-line metastatic pancreatic cancer: clinical and immunologic analyses from the randomized phase 2 PRINCE trial.
Nat Med
; 28(6): 1167-1177, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35662283
4.
Defining tumor resistance to PD-1 pathway blockade: recommendations from the first meeting of the SITC Immunotherapy Resistance Taskforce.
J Immunother Cancer
; 8(1)2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32238470
5.
Synthesis, antiproliferative, and pharmacokinetic properties of 3- and 17-double-modified analogs of 2-methoxyestradiol.
Bioorg Med Chem Lett
; 19(21): 6241-4, 2009 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19782564
6.
Synthesis and antitumor activities of 3-modified 2-methoxyestradiol analogs.
Bioorg Med Chem Lett
; 19(22): 6459-62, 2009 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19782568
7.
Synthesis of 2- and 17-substituted estrone analogs and their antiproliferative structure-activity relationships compared to 2-methoxyestradiol.
Bioorg Med Chem
; 17(20): 7344-52, 2009 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19762246
8.
Significant antitumor activity in vivo following treatment with the microtubule agent ENMD-1198.
Mol Cancer Ther
; 7(6): 1472-82, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18566218
9.
It Is a Capital Mistake to Theorize Who to Treat with Checkpoint Inhibitors before One Has Data.
Trends Cancer
; 5(2): 79-82, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30755306
10.
Antitumor effect of 2-methoxyestradiol in a rat orthotopic brain tumor model.
Cancer Res
; 66(24): 11991-7, 2006 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17178898
11.
2-methoxyestradiol induces mammary gland differentiation through amphiregulin-epithelial growth factor receptor-mediated signaling: molecular distinctions from the mammary gland of pregnant mice.
Endocrinology
; 148(3): 1266-77, 2007 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-17158205
12.
Synthesis and structure-activity relationships of 16-modified analogs of 2-methoxyestradiol.
Bioorg Med Chem
; 15(24): 7524-37, 2007 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17910916
13.
beta-Tubulin mutations are associated with resistance to 2-methoxyestradiol in MDA-MB-435 cancer cells.
Cancer Res
; 65(20): 9406-14, 2005 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16230404
14.
ErbB activation signatures as potential biomarkers for anti-ErbB3 treatment in HNSCC.
PLoS One
; 12(7): e0181356, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28723928
15.
KTN0158, a Humanized Anti-KIT Monoclonal Antibody, Demonstrates Biologic Activity against both Normal and Malignant Canine Mast Cells.
Clin Cancer Res
; 23(10): 2565-2574, 2017 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27815356
16.
Anti-KIT Monoclonal Antibody Treatment Enhances the Antitumor Activity of Immune Checkpoint Inhibitors by Reversing Tumor-Induced Immunosuppression.
Mol Cancer Ther
; 16(4): 671-680, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28138031
17.
Human Papillomavirus Regulates HER3 Expression in Head and Neck Cancer: Implications for Targeted HER3 Therapy in HPV+ Patients.
Clin Cancer Res
; 23(12): 3072-3083, 2017 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27986750
18.
2-methoxyestradiol up-regulates death receptor 5 and induces apoptosis through activation of the extrinsic pathway.
Cancer Res
; 63(2): 468-75, 2003 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-12543804
19.
2-Methoxyestradiol inhibits proliferation and induces apoptosis independently of estrogen receptors alpha and beta.
Cancer Res
; 62(13): 3691-7, 2002 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-12097276
20.
Correction: Human Papillomavirus Regulates HER3 Expression in Head and Neck Cancer: Implications for Targeted HER3 Therapy in HPV+ Patients.
Clin Cancer Res
; 27(14): 4129, 2021 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34261774