Detalhe da pesquisa
1.
Postnatal disruption of the disintegrin/metalloproteinase ADAM10 in brain causes epileptic seizures, learning deficits, altered spine morphology, and defective synaptic functions.
J Neurosci
; 33(32): 12915-28, 12928a, 2013 Aug 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-23926248
2.
Involvement of presenilin holoprotein upregulation in calcium dyshomeostasis of Alzheimer's disease.
J Cell Mol Med
; 17(2): 293-302, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23379308
3.
hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations.
Acta Neuropathol
; 125(3): 413-23, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23381195
4.
Rescue of progranulin deficiency associated with frontotemporal lobar degeneration by alkalizing reagents and inhibition of vacuolar ATPase.
J Neurosci
; 31(5): 1885-94, 2011 Feb 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-21289198
5.
Translational repression of the disintegrin and metalloprotease ADAM10 by a stable G-quadruplex secondary structure in its 5'-untranslated region.
J Biol Chem
; 286(52): 45063-72, 2011 Dec 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-22065584
6.
Expression of the anti-amyloidogenic secretase ADAM10 is suppressed by its 5'-untranslated region.
J Biol Chem
; 285(21): 15753-60, 2010 May 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-20348102
7.
Casein Kinase 2 dependent phosphorylation of eIF4B regulates BACE1 expression in Alzheimer's disease.
Cell Death Dis
; 12(8): 769, 2021 08 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34349120
8.
Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases.
Sci Transl Med
; 13(615): eabe5640, 2021 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34644146
9.
Requirement for small side chain residues within the GxGD-motif of presenilin for gamma-secretase substrate cleavage.
J Neurochem
; 112(4): 940-50, 2010 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-20021564
10.
Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.
J Cell Biol
; 158(3): 551-61, 2002 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-12147673
11.
Furin-, ADAM 10-, and gamma-secretase-mediated cleavage of a receptor tyrosine phosphatase and regulation of beta-catenin's transcriptional activity.
Mol Cell Biol
; 26(10): 3917-34, 2006 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-16648485
12.
TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis.
Sci Transl Med
; 6(243): 243ra86, 2014 Jul 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-24990881
13.
Function, regulation and therapeutic properties of beta-secretase (BACE1).
Semin Cell Dev Biol
; 20(2): 175-82, 2009 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19429494
14.
Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis.
Neuron
; 60(6): 988-1009, 2008 Dec 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-19109907
15.
Expression of the Alzheimer protease BACE1 is suppressed via its 5'-untranslated region.
EMBO Rep
; 5(6): 620-5, 2004 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-15167888
16.
Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD).
J Biol Chem
; 277(16): 13389-93, 2002 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-11809755
17.
Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide.
J Biol Chem
; 277(47): 44754-9, 2002 Nov 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-12223485
18.
Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation.
J Biol Chem
; 278(8): 5531-8, 2003 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-12471021