Detalhe da pesquisa
1.
DMSO-free highly differentiated HepaRG spheroids for chronic toxicity, liver functions and genotoxicity studies.
Arch Toxicol
; 96(1): 243-258, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34762139
2.
Constructing xenobiotic maps of metabolism to predict enzymes catalyzing metabolites capable of binding to DNA.
BMC Bioinformatics
; 22(1): 450, 2021 Sep 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-34548010
3.
Metabolism of the Tobacco Carcinogen 2-Amino-9H-pyrido[2,3-b]indole (AαC) in Primary Human Hepatocytes.
Chem Res Toxicol
; 30(2): 657-668, 2017 02 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27976871
4.
2-Amino-9H-pyrido[2,3-b]indole (AαC) Adducts and Thiol Oxidation of Serum Albumin as Potential Biomarkers of Tobacco Smoke.
J Biol Chem
; 290(26): 16304-18, 2015 Jun 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25953894
5.
Increasing 3D Matrix Rigidity Strengthens Proliferation and Spheroid Development of Human Liver Cells in a Constant Growth Factor Environment.
J Cell Biochem
; 117(3): 708-20, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26331987
6.
Mass Spectrometric Characterization of Human Serum Albumin Adducts Formed with N-Oxidized Metabolites of 2-Amino-1-methylphenylimidazo[4,5-b]pyridine in Human Plasma and Hepatocytes.
Chem Res Toxicol
; 28(5): 1045-59, 2015 May 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-25815793
7.
MEK1/2 overactivation can promote growth arrest by mediating ERK1/2-dependent phosphorylation of p70S6K.
J Cell Physiol
; 229(7): 903-15, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24501087
8.
Integrative analysis of high-throughput RNAi screen data identifies the FER and CRKL tyrosine kinases as new regulators of the mitogenic ERK-dependent pathways in transformed cells.
BMC Genomics
; 15: 1169, 2014 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-25540073
9.
Hepatotoxicity of cyanotoxin microcystin-LR in human: Insights into mechanisms of action in the 3D culture model Hepoid-HepaRG.
Environ Pollut
; 342: 123047, 2024 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38036087
10.
Assessment of endocrine disruptor impacts on lipid metabolism in a fatty acid-supplemented HepaRG human hepatic cell line.
Chemosphere
; 349: 140883, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38092172
11.
MAPK signaling in cisplatin-induced death: predominant role of ERK1 over ERK2 in human hepatocellular carcinoma cells.
Carcinogenesis
; 34(1): 38-47, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23042098
12.
UDP-glucuronosyltransferase-mediated metabolic activation of the tobacco carcinogen 2-amino-9H-pyrido[2,3-b]indole.
J Biol Chem
; 287(18): 14960-72, 2012 Apr 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-22393056
13.
DNA adducts of the tobacco carcinogens 2-amino-9H-pyrido[2,3-b]indole and 4-aminobiphenyl are formed at environmental exposure levels and persist in human hepatocytes.
Chem Res Toxicol
; 26(9): 1367-77, 2013 Sep 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-23898916
14.
ReadEDTest: A tool to assess the readiness of in vitro test methods under development for identifying endocrine disruptors.
Environ Int
; 174: 107910, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37028267
15.
DNA adducts of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 4-aminobiphenyl are infrequently detected in human mammary tissue by liquid chromatography/tandem mass spectrometry.
Carcinogenesis
; 33(1): 124-30, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22072616
16.
The complexity of ERK1 and ERK2 MAPKs in multiple hepatocyte fate responses.
J Cell Physiol
; 227(1): 59-69, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21437905
17.
In vitrolong term differentiation and functionality of three-dimensional bioprinted primary human hepatocytes: application forin vivoengraftment.
Biofabrication
; 14(3)2022 06 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-35696992
18.
Obesity III: Obesogen assays: Limitations, strengths, and new directions.
Biochem Pharmacol
; 199: 115014, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35393121
19.
Combinatorial pathway disruption is a powerful approach to delineate metabolic impacts of endocrine disruptors.
FEBS Lett
; 596(24): 3107-3123, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35957500
20.
Obesity II: Establishing causal links between chemical exposures and obesity.
Biochem Pharmacol
; 199: 115015, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35395240