Detalhe da pesquisa
1.
Novel quinazolinone Derivatives: Design, synthesis and in vivo evaluation as potential agents targeting Alzheimer disease.
Bioorg Chem
; 143: 107065, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38150939
2.
Design, synthesis, and biological evaluation of new thieno[2,3-d] pyrimidine derivatives as targeted therapy for PI3K with molecular modelling study.
J Enzyme Inhib Med Chem
; 37(1): 315-332, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34955086
3.
Molecular design, synthesis and biological evaluation of novel 1,2,5-trisubstituted benzimidazole derivatives as cytotoxic agents endowed with ABCB1 inhibitory action to overcome multidrug resistance in cancer cells.
J Enzyme Inhib Med Chem
; 37(1): 2710-2724, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-36168121
4.
Scaffold hopping and redesign approaches for quinazoline based urea derivatives as potent VEGFR-2 inhibitors.
Bioorg Chem
; 101: 103961, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32480170
5.
3D-QSAR pharmacophore modelling, virtual screening and docking studies for lead discovery of a novel scaffold for VEGFR 2 inhibitors: Design, synthesis and biological evaluation.
Bioorg Chem
; 89: 102988, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31146197
6.
Design and synthesis of phthalazine-based compounds as potent anticancer agents with potential antiangiogenic activity via VEGFR-2 inhibition.
J Enzyme Inhib Med Chem
; 34(1): 1347-1367, 2019 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-31322015
7.
Chimeric HDAC inhibitors: Comprehensive review on the HDAC-based strategies developed to combat cancer.
Med Res Rev
; 38(6): 2058-2109, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29733427
8.
Identification of new pyrrolo[2,3-d]pyrimidines as potent VEGFR-2 tyrosine kinase inhibitors: Design, synthesis, biological evaluation and molecular modeling.
Bioorg Chem
; 81: 612-629, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30248512
9.
Imidazo[2',1':2,3]thiazolo[4,5-d]pyridazinone as a new scaffold of DHFR inhibitors: Synthesis, biological evaluation and molecular modeling study.
Bioorg Chem
; 80: 11-23, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29864684
10.
Thiazolo[4,5-d]pyridazine analogues as a new class of dihydrofolate reductase (DHFR) inhibitors: Synthesis, biological evaluation and molecular modeling study.
Bioorg Chem
; 74: 228-237, 2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28865294
11.
Toward discovery of mutant EGFR inhibitors; Design, synthesis and in vitro biological evaluation of potent 4-arylamino-6-ureido and thioureido-quinazoline derivatives.
Bioorg Med Chem
; 24(16): 3501-12, 2016 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27288180
12.
Covalent EGFR Inhibitors: Binding Mechanisms, Synthetic Approaches, and Clinical Profiles.
Arch Pharm (Weinheim)
; 349(8): 573-93, 2016 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-27258393
13.
Design and Synthesis of 4-Anilinothieno[2,3-d]pyrimidine-Based Compounds as Dual EGFR/HER-2 Inhibitors.
Arch Pharm (Weinheim)
; 349(11): 827-847, 2016 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-27734525
14.
Design and synthesis of benzothiazole-6-sulfonamides acting as highly potent inhibitors of carbonic anhydrase isoforms I, II, IX and XII.
Bioorg Med Chem
; 23(15): 4989-4999, 2015 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26048024
15.
Targeting apoptosis; design, synthesis and biological evaluation of new benzoxazole and thiazole based derivatives.
BMC Chem
; 18(1): 1, 2024 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38173026
16.
Analogs design, synthesis and biological evaluation of peptidomimetics with potential anti-HCV activity.
Bioorg Med Chem
; 21(10): 2742-55, 2013 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23583031
17.
Design, molecular modelling and synthesis of novel benzothiazole derivatives as BCL-2 inhibitors.
Sci Rep
; 13(1): 15554, 2023 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-37730790
18.
A Fluorescence-Based Assay to Probe Inhibitory Effect of Fructose Mimics on GLUT5 Transport in Breast Cancer Cells.
ACS Bio Med Chem Au
; 3(1): 51-61, 2023 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37101605
19.
Identification of novel furo[2,3-d]pyrimidine based chalcones as potent anti-breast cancer agents: synthesis, in vitro and in vivo biological evaluation.
RSC Adv
; 12(13): 8193-8201, 2022 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35424720
20.
Novel benzenesulfonamides aryl and arylsulfone conjugates adopting tail/dual tail approaches: Synthesis, carbonic anhydrase inhibitory activity and molecular modeling studies.
Eur J Med Chem
; 221: 113486, 2021 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33965860