MEDICO - SOCIAL SUBSTANTIATION OF THE CONCEPT OF PERSONALIZED MEDICINE IN THE PREVENTION OF ARTERIAL HYPERTENSION AMONG THE ADULT POPULATION AT THE REGIONAL LEVEL.

OBJECTIVE: The aim: Is to scientifically substantiate the concept of personalized medicine in the prevention of arterial hypertension (AH) among the adult population at the regional level. PATIENTS AND METHODS: Materials and methods: The study, after obtaining informed consent, involved 2000 patients, residents of Zaporizhzhia Region, including 1000 patients (average age 59±0.5 years, the ratio of men to women 1:1.22 people) with and 1000 patients (average age of whom is 62±0.7 years, the ratio of men to women is 1:1.1) without AH. The data of the sociological survey were processed, the methods of mathematical modeling, statistical, system analysis were applied. Odds ratio (OR) is determined by generally accepted methods with the calculation of 95% of confidence interval (CI). RESULTS: Results: The application of the concept of personalized medicine in the prevention of AH among the adult population has been scientifically substantiated by studying the associations between medical and social risk factors and the development of AH and determining on their basis 3 modules - "risk behavior", "adverse health factors" and "social determinants of the development of AH", based on stepwise multiple logistic regression analysis. CONCLUSION: Conclusions: It has been proved that the use of the final prognostic model of the development of arterial hypertension with the inclusion of the most significant risk factorshas high operational characteristics: sensitivity - 78.6%, specificity - 96.6%, positive predicative value - 95.85%, negative predicative value - 81.86%, the area under the ROC curve is 0.9623. The application of the concept of personalized medicine in the prevention of this disease among the adult population was substantiated by studying the associations between medical and social risk factors and the development of arterial hypertension.

Education of Patients With Atrial Fibrillation and Evaluation of the Efficacy of a Mobile Virtual Patient Environment: Protocol for a Multicenter Pseudorandomized Controlled Trial.

BACKGROUND: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is a leading cause of mortality and morbidity. Patient knowledge about AF and its management is paramount but often limited. Patients need to be appropriately informed about treatment options, medicinal adherence, and potential consequences of nonadherence, while also understanding treatment goals and expectations from it. Mobile health apps have experienced an explosion both in their availability and acceptance as "soft interventions" for patient engagement and education; however, the prolific nature of such solutions revealed a gap in the evidence base regarding their efficacy and impact. Virtual patients (VPs), interactive computer simulations, have been used as learning activities in modern health care education. VPs demonstrably improved cognitive and behavioral skills; hence, they have been effectively implemented across undergraduate and postgraduate curricula. However, their application in patient education has been rather limited so far. OBJECTIVE: This work aims to implement and evaluate the efficacy of a mobile-deployed VP regimen for the education and engagement of patients with AF on crucial topics regarding their condition. A mobile VP app is being developed with the goal of each VP being a simple scenario with a set goal and very specific messages and will be subsequently attempted and evaluated. METHODS: A mobile VP player app is being developed so as to be used for the design of 3 educational scenarios for AF management. A pseudorandomized controlled trial for the efficacy of VPs is planned to be executed at 3 sites in Greece, Ukraine, and Kazakhstan for patients with AF. The Welch t test will be used to demonstrate the performance of patients' evaluation of the VP experience. RESULTS: Our study is at the development stage. A preliminary study regarding the system's development and feasibility was initiated in December 2022. The results of our study are expected to be available in 2024 or when the needed sample size is achieved. CONCLUSIONS: This study aims to evaluate and demonstrate the first significant evidence for the value of VP resources in outreach and training endeavors for empowering and patients with AF and fostering healthy habits among them. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): PRR1-10.2196/45946.