Detalhe da pesquisa
1.
Ligand and Target Discovery by Fragment-Based Screening in Human Cells.
Cell
; 168(3): 527-541.e29, 2017 01 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28111073
2.
An optimized agonist peptide of protease-activated receptor 4 and its use in a validated platelet-aggregation assay.
Platelets
; 33(7): 979-986, 2022 Oct 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35343875
3.
Discovery and SAR of aryl hydroxy pyrimidinones as potent small molecule agonists of the GPCR APJ.
Bioorg Med Chem Lett
; 30(7): 126955, 2020 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32035698
4.
Linking (Pyr)1apelin-13 pharmacokinetics to efficacy: Stabilization and measurement of a high clearance peptide in rodents.
Anal Biochem
; 568: 41-50, 2019 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30605634
5.
Characterization of monoacylglycerol acyltransferase 2 inhibitors by a novel probe in binding assays.
Anal Biochem
; 501: 48-55, 2016 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26925857
6.
Cell-based assay of MGAT2-driven diacylglycerol synthesis for profiling inhibitors: use of a stable isotope-labeled substrate and high-resolution LC/MS.
J Lipid Res
; 56(3): 747-753, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25598079
7.
1H NMR-based lipidomics of rodent fur: species-specific lipid profiles and SCD1 inhibitor-related dermal toxicity.
J Lipid Res
; 55(7): 1366-74, 2014 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-24755647
8.
Diphenylpyridylethanamine (DPPE)-based aminoheterocycles as cholesteryl ester transfer protein inhibitors.
Bioorg Med Chem Lett
; 24(3): 860-4, 2014 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24424134
9.
Discovery of Potent and Selective Quinoxaline-Based Protease-Activated Receptor 4 (PAR4) Antagonists for the Prevention of Arterial Thrombosis.
J Med Chem
; 67(5): 3571-3589, 2024 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38385264
10.
Identification of a potent and metabolically stable series of fluorinated diphenylpyridylethanamine-based cholesteryl ester transfer protein inhibitors.
Bioorg Med Chem Lett
; 22(20): 6503-8, 2012 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22995620
11.
MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity.
Cell Metab
; 34(11): 1732-1748.e5, 2022 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36323235
12.
Arylsulfonamidopiperidone derivatives as a novel class of factor Xa inhibitors.
Bioorg Med Chem Lett
; 21(24): 7516-21, 2011 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22041058
13.
Evaluation of fully-functionalized diazirine tags for chemical proteomic applications.
Chem Sci
; 12(22): 7839-7847, 2021 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34168837
14.
Rapid Compound Integrity Assessment for High-Throughput Screening Hit Triaging.
SLAS Discov
; 26(2): 242-247, 2021 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-32400264
15.
Screening Hit to Clinical Candidate: Discovery of BMS-963272, a Potent, Selective MGAT2 Inhibitor for the Treatment of Metabolic Disorders.
J Med Chem
; 64(19): 14773-14792, 2021 10 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34613725
16.
Design and synthesis of a G-protein-coupled receptor antagonist library of aryloxyalkanolamines using a polymer-supported acyclic acetal linker.
J Comb Chem
; 11(1): 72-82, 2009.
Artigo
em Inglês
| MEDLINE | ID: mdl-19086798
17.
Expedited mapping of the ligandable proteome using fully functionalized enantiomeric probe pairs.
Nat Chem
; 11(12): 1113-1123, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31659311
18.
Biphenyl Acid Derivatives as APJ Receptor Agonists.
J Med Chem
; 62(22): 10456-10465, 2019 11 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31724863
19.
Discovery of a Lead Triphenylethanamine Cholesterol Ester Transfer Protein (CETP) Inhibitor.
ACS Med Chem Lett
; 10(6): 911-916, 2019 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31223447
20.
Discovery of Potent Protease-Activated Receptor 4 Antagonists with in Vivo Antithrombotic Efficacy.
J Med Chem
; 62(16): 7400-7416, 2019 08 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-31246024