Detalhe da pesquisa
1.
Harnessing biosynthesis and quantitative NMR for late stage functionalization of lead molecules: Application to the M1 positive allosteric modulator (PAM) program.
Bioorg Med Chem Lett
; 28(11): 2068-2073, 2018 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29716781
2.
Characterization of a Novel M1 Muscarinic Acetylcholine Receptor Positive Allosteric Modulator Radioligand, [3H]PT-1284.
Mol Pharmacol
; 90(3): 177-87, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27382013
3.
Design and optimization of selective azaindole amide M1 positive allosteric modulators.
Bioorg Med Chem Lett
; 26(2): 650-655, 2016 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26631313
4.
Positive allosteric modulation of AMPA receptors from efficacy to toxicity: the interspecies exposure-response continuum of the novel potentiator PF-4778574.
J Pharmacol Exp Ther
; 347(1): 212-24, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23899905
5.
3-Benzyl-1,3-oxazolidin-2-ones as mGluR2 positive allosteric modulators: Hit-to lead and lead optimization.
Bioorg Med Chem Lett
; 19(9): 2524-9, 2009 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19328692
6.
Striatal, Hippocampal, and Cortical Networks Are Differentially Responsive to the M4- and M1-Muscarinic Acetylcholine Receptor Mediated Effects of Xanomeline.
ACS Chem Neurosci
; 10(3): 1753-1764, 2019 03 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-30480428
7.
Discovery of Selective M4 Muscarinic Acetylcholine Receptor Agonists with Novel Carbamate Isosteres.
ACS Med Chem Lett
; 10(6): 941-948, 2019 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-31223452
8.
3-(Imidazolyl methyl)-3-aza-bicyclo[3.1.0]hexan-6-yl)methyl ethers: a novel series of mGluR2 positive allosteric modulators.
Bioorg Med Chem Lett
; 18(20): 5493-6, 2008 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18812259
9.
Synthesis of novel pyrrolo[3,4-d]pyrazole-dicarboxylic acids and evaluation of their interaction with glutamate receptors.
Chem Biodivers
; 5(4): 657-63, 2008 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-18421758
10.
Design and Synthesis of γ- and δ-Lactam M1 Positive Allosteric Modulators (PAMs): Convulsion and Cholinergic Toxicity of an M1-Selective PAM with Weak Agonist Activity.
J Med Chem
; 60(15): 6649-6663, 2017 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28598634
11.
The Discovery of a Novel Phosphodiesterase (PDE) 4B-Preferring Radioligand for Positron Emission Tomography (PET) Imaging.
J Med Chem
; 60(20): 8538-8551, 2017 10 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28957634
12.
Discovery and Characterization of (R)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates.
J Med Chem
; 60(18): 7764-7780, 2017 09 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-28817277
13.
Discovery of the Potent and Selective M1 PAM-Agonist N-[(3R,4S)-3-Hydroxytetrahydro-2H-pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of Efficacy and Cholinergic Side Effects.
J Med Chem
; 59(13): 6313-28, 2016 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27275946
14.
The discovery and characterization of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor potentiator N-{(3S,4S)-4-[4-(5-cyano-2-thienyl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide (PF-04958242).
J Med Chem
; 58(10): 4291-308, 2015 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-25905800
15.
Striatal, Hippocampal, and Cortical Networks Are Differentially Responsive to the M4- and M1-Muscarinic Acetylcholine Receptor Mediated Effects of Xanomeline.
ACS Chem Neurosci
; 10(8): 3910, 2019 Aug 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31286767
16.
Discovery and preclinical characterization of 1-methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)-1H-pyrazolo-[3,4-b]pyrazine (PF470): a highly potent, selective, and efficacious metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator.
J Med Chem
; 57(3): 861-77, 2014 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24392688
17.
Discovery and characterization of a novel dihydroisoxazole class of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor potentiators.
J Med Chem
; 56(22): 9180-91, 2013 Nov 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24215237
18.
1-[(1-methyl-1H-imidazol-2-yl)methyl]-4-phenylpiperidines as mGluR2 positive allosteric modulators for the treatment of psychosis.
J Med Chem
; 54(6): 1724-39, 2011 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-21366332