Pesquisa | Portal de Pesquisa da BVS Enfermagem

1.

Enhancer-promoter interactions are reconfigured through the formation of long-range multiway hubs as mouse ES cells exit pluripotency.

Lando, David; Ma, Xiaoyan; Cao, Yang; Jartseva, Aleksandra; Stevens, Tim J; Boucher, Wayne; Reynolds, Nicola; Montibus, Bertille; Hall, Dominic; Lackner, Andreas; Ragheb, Ramy; Leeb, Martin; Hendrich, Brian D; Laue, Ernest D.

Mol Cell ; 84(8): 1406-1421.e8, 2024 Apr 18.

Artigo em Inglês | MEDLINE | ID: mdl-38490199

2.

NMD is required for timely cell fate transitions by fine-tuning gene expression and regulating translation.

Huth, Michelle; Santini, Laura; Galimberti, Elena; Ramesmayer, Julia; Titz-Teixeira, Fabian; Sehlke, Robert; Oberhuemer, Michael; Stummer, Sarah; Herzog, Veronika; Garmhausen, Marius; Romeike, Merrit; Chugunova, Anastasia; Leesch, Friederike; Holcik, Laurenz; Weipoltshammer, Klara; Lackner, Andreas; Schoefer, Christian; von Haeseler, Arndt; Buecker, Christa; Pauli, Andrea; Ameres, Stefan L; Smith, Austin; Beyer, Andreas; Leeb, Martin.

Genes Dev ; 36(5-6): 348-367, 2022 03 01.

Artigo em Inglês | MEDLINE | ID: mdl-35241478

3.

Temporal dissection of an enhancer cluster reveals distinct temporal and functional contributions of individual elements.

Thomas, Henry F; Kotova, Elena; Jayaram, Swathi; Pilz, Axel; Romeike, Merrit; Lackner, Andreas; Penz, Thomas; Bock, Christoph; Leeb, Martin; Halbritter, Florian; Wysocka, Joanna; Buecker, Christa.

Mol Cell ; 81(5): 969-982.e13, 2021 03 04.

Artigo em Inglês | MEDLINE | ID: mdl-33482114

4.

Enhancers of the PAIR4 regulatory module promote distal V_H gene recombination at the Igh locus.

Hill, Louisa; Jaritz, Markus; Tagoh, Hiromi; Schindler, Karina; Kostanova-Poliakova, Daniela; Sun, Qiong; Schwickert, Tanja A; Leeb, Martin; Busslinger, Meinrad.

EMBO J ; 42(15): e112741, 2023 08 01.

Artigo em Inglês | MEDLINE | ID: mdl-37337907

5.

Cooperative genetic networks drive embryonic stem cell transition from naïve to formative pluripotency.

Lackner, Andreas; Sehlke, Robert; Garmhausen, Marius; Giuseppe Stirparo, Giuliano; Huth, Michelle; Titz-Teixeira, Fabian; van der Lelij, Petra; Ramesmayer, Julia; Thomas, Henry F; Ralser, Meryem; Santini, Laura; Galimberti, Elena; Sarov, Mihail; Stewart, A Francis; Smith, Austin; Beyer, Andreas; Leeb, Martin.

EMBO J ; 40(8): e105776, 2021 04 15.

Artigo em Inglês | MEDLINE | ID: mdl-33687089

6.

3D structures of individual mammalian genomes studied by single-cell Hi-C.

Stevens, Tim J; Lando, David; Basu, Srinjan; Atkinson, Liam P; Cao, Yang; Lee, Steven F; Leeb, Martin; Wohlfahrt, Kai J; Boucher, Wayne; O'Shaughnessy-Kirwan, Aoife; Cramard, Julie; Faure, Andre J; Ralser, Meryem; Blanco, Enrique; Morey, Lluis; Sansó, Miriam; Palayret, Matthieu G S; Lehner, Ben; Di Croce, Luciano; Wutz, Anton; Hendrich, Brian; Klenerman, Dave; Laue, Ernest D.

Nature ; 544(7648): 59-64, 2017 04 06.

Artigo em Inglês | MEDLINE | ID: mdl-28289288

7.

Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination.

Eskeland, Ragnhild; Leeb, Martin; Grimes, Graeme R; Kress, Clémence; Boyle, Shelagh; Sproul, Duncan; Gilbert, Nick; Fan, Yuhong; Skoultchi, Arthur I; Wutz, Anton; Bickmore, Wendy A.

Mol Cell ; 38(3): 452-64, 2010 May 14.

Artigo em Inglês | MEDLINE | ID: mdl-20471950

8.

Polycomb complexes act redundantly to repress genomic repeats and genes.

Leeb, Martin; Pasini, Diego; Novatchkova, Maria; Jaritz, Markus; Helin, Kristian; Wutz, Anton.

Genes Dev ; 24(3): 265-76, 2010 Feb 01.

Artigo em Inglês | MEDLINE | ID: mdl-20123906

9.

Derivation of haploid embryonic stem cells from mouse embryos.

Leeb, Martin; Wutz, Anton.

Nature ; 479(7371): 131-4, 2011 Sep 07.

Artigo em Inglês | MEDLINE | ID: mdl-21900896

10.

Germline potential of parthenogenetic haploid mouse embryonic stem cells.

Leeb, Martin; Walker, Rachael; Mansfield, Bill; Nichols, Jenny; Smith, Austin; Wutz, Anton.

Development ; 139(18): 3301-5, 2012 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-22912412

11.

Establishment of epigenetic patterns in development.

Leeb, Martin; Wutz, Anton.

Chromosoma ; 121(3): 251-62, 2012 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-22427185

12.

The Trithorax group protein Ash2l and Saf-A are recruited to the inactive X chromosome at the onset of stable X inactivation.

Pullirsch, Dieter; Härtel, Renate; Kishimoto, Hiroyuki; Leeb, Martin; Steiner, Günter; Wutz, Anton.

Development ; 137(6): 935-43, 2010 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-20150277

13.

Genome-wide screening in pluripotent cells identifies Mtf1 as a suppressor of mutant huntingtin toxicity.

Ferlazzo, Giorgia Maria; Gambetta, Anna Maria; Amato, Sonia; Cannizzaro, Noemi; Angiolillo, Silvia; Arboit, Mattia; Diamante, Linda; Carbognin, Elena; Romani, Patrizia; La Torre, Federico; Galimberti, Elena; Pflug, Florian; Luoni, Mirko; Giannelli, Serena; Pepe, Giuseppe; Capocci, Luca; Di Pardo, Alba; Vanzani, Paola; Zennaro, Lucio; Broccoli, Vania; Leeb, Martin; Moro, Enrico; Maglione, Vittorio; Martello, Graziano.

Nat Commun ; 14(1): 3962, 2023 07 05.

Artigo em Inglês | MEDLINE | ID: mdl-37407555

14.

Ring1B is crucial for the regulation of developmental control genes and PRC1 proteins but not X inactivation in embryonic cells.

Leeb, Martin; Wutz, Anton.

J Cell Biol ; 178(2): 219-29, 2007 Jul 16.

Artigo em Inglês | MEDLINE | ID: mdl-17620408

15.

Genomic imprinting in mouse blastocysts is predominantly associated with H3K27me3.

Santini, Laura; Halbritter, Florian; Titz-Teixeira, Fabian; Suzuki, Toru; Asami, Maki; Ma, Xiaoyan; Ramesmayer, Julia; Lackner, Andreas; Warr, Nick; Pauler, Florian; Hippenmeyer, Simon; Laue, Ernest; Farlik, Matthias; Bock, Christoph; Beyer, Andreas; Perry, Anthony C F; Leeb, Martin.

Nat Commun ; 12(1): 3804, 2021 06 21.

Artigo em Inglês | MEDLINE | ID: mdl-34155196

16.

PHF3 regulates neuronal gene expression through the Pol II CTD reader domain SPOC.

Appel, Lisa-Marie; Franke, Vedran; Bruno, Melania; Grishkovskaya, Irina; Kasiliauskaite, Aiste; Kaufmann, Tanja; Schoeberl, Ursula E; Puchinger, Martin G; Kostrhon, Sebastian; Ebenwaldner, Carmen; Sebesta, Marek; Beltzung, Etienne; Mechtler, Karl; Lin, Gen; Vlasova, Anna; Leeb, Martin; Pavri, Rushad; Stark, Alexander; Akalin, Altuna; Stefl, Richard; Bernecky, Carrie; Djinovic-Carugo, Kristina; Slade, Dea.

Nat Commun ; 12(1): 6078, 2021 10 19.

Artigo em Inglês | MEDLINE | ID: mdl-34667177

17.

X chromosome inactivation sparked by non-coding RNAs.

Leeb, Martin; Steffen, Philipp A; Wutz, Anton.

RNA Biol ; 6(2): 94-9, 2009.

Artigo em Inglês | MEDLINE | ID: mdl-19246991

18.

Combining fluorescence imaging with Hi-C to study 3D genome architecture of the same single cell.

Lando, David; Basu, Srinjan; Stevens, Tim J; Riddell, Andy; Wohlfahrt, Kai J; Cao, Yang; Boucher, Wayne; Leeb, Martin; Atkinson, Liam P; Lee, Steven F; Hendrich, Brian; Klenerman, Dave; Laue, Ernest D.

Nat Protoc ; 13(5): 1034-1061, 2018 05.

Artigo em Inglês | MEDLINE | ID: mdl-29674753

19.

Gasping for victory.

Leeb, Martin.

Nature ; 430(7000): 608-9, 2004 Aug 05.

Artigo em Inglês | MEDLINE | ID: mdl-15295569

20.

Antibiotics: a shot in the arm.

Leeb, Martin.

Nature ; 431(7011): 892-3, 2004 Oct 21.

Artigo em Inglês | MEDLINE | ID: mdl-15496888

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Enhancer-promoter interactions are reconfigured through the formation of long-range multiway hubs as mouse ES cells exit pluripotency.

NMD is required for timely cell fate transitions by fine-tuning gene expression and regulating translation.

Temporal dissection of an enhancer cluster reveals distinct temporal and functional contributions of individual elements.

Enhancers of the PAIR4 regulatory module promote distal V_H gene recombination at the Igh locus.

Cooperative genetic networks drive embryonic stem cell transition from naïve to formative pluripotency.

3D structures of individual mammalian genomes studied by single-cell Hi-C.

Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination.

Polycomb complexes act redundantly to repress genomic repeats and genes.

Derivation of haploid embryonic stem cells from mouse embryos.

Germline potential of parthenogenetic haploid mouse embryonic stem cells.

Establishment of epigenetic patterns in development.

The Trithorax group protein Ash2l and Saf-A are recruited to the inactive X chromosome at the onset of stable X inactivation.

Genome-wide screening in pluripotent cells identifies Mtf1 as a suppressor of mutant huntingtin toxicity.

Ring1B is crucial for the regulation of developmental control genes and PRC1 proteins but not X inactivation in embryonic cells.

Genomic imprinting in mouse blastocysts is predominantly associated with H3K27me3.

PHF3 regulates neuronal gene expression through the Pol II CTD reader domain SPOC.

X chromosome inactivation sparked by non-coding RNAs.

Combining fluorescence imaging with Hi-C to study 3D genome architecture of the same single cell.

Gasping for victory.

Antibiotics: a shot in the arm.