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1.
Opt Express ; 25(17): 20243-20257, 2017 Aug 21.
Artigo em Inglês | MEDLINE | ID: mdl-29041707

RESUMO

Translational, rotational, vibrational and electron temperatures of a gliding arc discharge in atmospheric pressure air were experimentally investigated using in situ, non-intrusive optical diagnostic techniques. The gliding arc discharge was driven by a 35 kHz alternating current (AC) power source and operated in a glow-type regime. The two-dimensional distribution of the translational temperature (Tt) of the gliding arc discharge was determined using planar laser-induced Rayleigh scattering. The rotational and vibrational temperatures were obtained by simulating the experimental spectra. The OH A-X (0, 0) band was used to simulate the rotational temperature (Tr) of the gliding arc discharge whereas the NO A-X (1, 0) and (0, 1) bands were used to determine its vibrational temperature (Tv). The instantaneous reduced electric field strength E/N was obtained by simultaneously measuring the instantaneous length of the plasma column, the discharge voltage and the translational temperature, from which the electron temperature (Te) of the gliding arc discharge was estimated. The uncertainties of the translational, rotational, vibrational and electron temperatures were analyzed. The relations of these four different temperatures (Te>Tv>Tr >Tt) suggest a high-degree non-equilibrium state of the gliding arc discharge.

2.
Kidney Int ; 90(2): 422-429, 2016 08.
Artigo em Inglês | MEDLINE | ID: mdl-27262365

RESUMO

Managing anemia in hemodialysis patients can be challenging because of competing therapeutic targets and individual variability. Because therapy recommendations provided by a decision support system can benefit both patients and doctors, we evaluated the impact of an artificial intelligence decision support system, the Anemia Control Model (ACM), on anemia outcomes. Based on patient profiles, the ACM was built to recommend suitable erythropoietic-stimulating agent doses. Our retrospective study consisted of a 12-month control phase (standard anemia care), followed by a 12-month observation phase (ACM-guided care) encompassing 752 patients undergoing hemodialysis therapy in 3 NephroCare clinics located in separate countries. The percentage of hemoglobin values on target, the median darbepoetin dose, and individual hemoglobin fluctuation (estimated from the intrapatient hemoglobin standard deviation) were deemed primary outcomes. In the observation phase, median darbepoetin consumption significantly decreased from 0.63 to 0.46 µg/kg/month, whereas on-target hemoglobin values significantly increased from 70.6% to 76.6%, reaching 83.2% when the ACM suggestions were implemented. Moreover, ACM introduction led to a significant decrease in hemoglobin fluctuation (intrapatient standard deviation decreased from 0.95 g/dl to 0.83 g/dl). Thus, ACM support helped improve anemia outcomes of hemodialysis patients, minimizing erythropoietic-stimulating agent use with the potential to reduce the cost of treatment.


Assuntos
Anemia/tratamento farmacológico , Inteligência Artificial , Tomada de Decisão Clínica/métodos , Darbepoetina alfa/uso terapêutico , Sistemas de Apoio a Decisões Clínicas , Hematínicos/uso terapêutico , Hemoglobinas/análise , Falência Renal Crônica/complicações , Idoso , Darbepoetina alfa/administração & dosagem , Feminino , Hematínicos/administração & dosagem , Humanos , Falência Renal Crônica/terapia , Masculino , Pessoa de Meia-Idade , Diálise Renal , Estudos Retrospectivos
3.
Food Microbiol ; 30(1): 233-8, 2012 May.
Artigo em Inglês | MEDLINE | ID: mdl-22265306

RESUMO

The application of cold atmospheric pressure plasma for decontamination of a sliced ready-to-eat (RTE) meat product (bresaola) inoculated with Listeria innocua was investigated. Inoculated samples were treated at 15.5, 31, and 62 W for 2-60 s inside sealed linear-low-density-polyethylene bags containing 30% oxygen and 70% argon. Treatments resulted in a reduction of L. innocua ranging from 0.8 ± 0.4 to 1.6 ± 0.5 log cfu/g with no significant effects of time and intensity while multiple treatments at 15.5 and 62 W of 20 s with a 10 min interval increased reduction of L. innocua with increasing number of treatments. Concentrations of thiobarbituric acid reactive substances (TBARS) increased with power, treatments and storage time and were significantly higher than those of control samples after 1 and 14 days of storage at 5 °C. However, the levels were low (from 0.1 to 0.4 mg/kg) and beneath the sensory threshold level. Surface colour changes included loss of redness of ∼40% and 70% after 1 and 14 days of storage, respectively, regardless of plasma treatment. The results indicate that plasma may be applicable in surface decontamination of pre-packed RTE food products. However, oxidation may constitute an issue in some products.


Assuntos
Temperatura Baixa , Contaminação de Alimentos/análise , Microbiologia de Alimentos/métodos , Embalagem de Alimentos/métodos , Listeria monocytogenes/isolamento & purificação , Produtos da Carne/microbiologia , Dióxido de Carbono/análise , Contagem de Colônia Microbiana , Cor , Qualidade de Produtos para o Consumidor , Conservação de Alimentos/métodos , Listeria monocytogenes/crescimento & desenvolvimento , Oxigênio/análise , Ozônio/análise , Pressão , Substâncias Reativas com Ácido Tiobarbitúrico/análise
4.
Rev Sci Instrum ; 79(6): 065103, 2008 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-18601433

RESUMO

In the present paper, a device is introduced, which is capable of determining the three characteristic parameters of elliptically polarized light (ellipticity, angle of ellipticity, and direction of rotation) for microwave radiation at a frequency of 110 GHz. The device consists of two perpendicular orientated pickup waveguides. A heterodyne technique mixes the microwave frequency down to frequencies on the order of 200 MHz. An oscilloscope is used to determine the relative amplitudes of the electrical fields and the phase shift in between, from which the three characteristic parameters can be calculated. Results from measured and calculated wave characteristics of an elliptically polarized 110 GHz microwave beam for plasma heating launched into the TEXTOR-tokamak experiment are presented. Measurement and calculation are in good agreement.

5.
Bioresour Technol ; 140: 36-42, 2013 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-23672937

RESUMO

A qualified estimate for pretreatment of the macroalgae Chaetomorpha linum for ethanol production was given, based on the experience of pretreatment of land-based biomass. C. linum was subjected to hydrothermal pretreatment (HTT), wet oxidation (WO), steam explosion (STEX), plasma-assisted pretreatment (PAP) and ball milling (BM), to determine effects of the pretreatment methods on the conversion of C. linum into ethanol by simultaneous saccharification and fermentation (SSF). WO and BM showed the highest ethanol yield of 44 g ethanol/100g glucan, which was close to the theoretical ethanol yield of 57 g ethanol/100g glucan. A 64% higher ethanol yield, based on raw material, was reached after pretreatment with WO and BM compared with unpretreated C. linum, however 50% of the biomass was lost during WO. Results indicated that the right combination of pretreatment and marine macroalgae, containing high amounts of glucan and cleaned from salts, enhanced the ethanol yield significantly.


Assuntos
Biocombustíveis , Biotecnologia/métodos , Etanol/metabolismo , Alga Marinha/metabolismo , Biomassa , Carboidratos/análise , Fermentação/efeitos dos fármacos , Hidrólise/efeitos dos fármacos , Oxirredução/efeitos dos fármacos , Gases em Plasma/farmacologia , Alga Marinha/química , Alga Marinha/efeitos dos fármacos , Vapor , Temperatura , Água/farmacologia
6.
Appl Biochem Biotechnol ; 165(3-4): 1010-23, 2011 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-21728026

RESUMO

The potential of wheat straw for ethanol production after pretreatment with O(3) generated in a plasma at atmospheric pressure and room temperature followed by fermentation was investigated. We found that cellulose and hemicellulose remained unaltered after ozonisation and a subsequent washing step, while lignin was degraded up to 95% by O(3). The loss of biomass after washing could be explained by the amount of lignin degraded. The washing water of pretreated samples (0-7 h) was analyzed for potential fermentation inhibitors. Approximately 30 lignin degradation products and a number of simple carboxylic acids and phenolic compounds were found, e.g., vanillic acid, acetic acid, and formic acid. Some components had the highest concentration at the beginning of the ozonisation process (0.5, 1 h), e.g., 4-hydroxybenzladehyde, while the concentration of others increased during the entire pretreatment (0-7 h), e.g., oxalic acid and acetovanillon. Interestingly, washing had no effect on the ethanol production with pretreatment times up to 1 h. Washing improved the glucose availability with pretreatment times of more than 2 h. One hour of ozonisation was found to be optimal for the use of washed and unwashed wheat straw for ethanol production (maximum ethanol yield, 52%). O(3) cost estimations were made for the production of ethanol at standard conditions.


Assuntos
Biocombustíveis , Biotecnologia/métodos , Etanol/metabolismo , Lignina/metabolismo , Ozônio/metabolismo , Gases em Plasma/química , Triticum/metabolismo , Acetofenonas/metabolismo , Benzaldeídos/metabolismo , Biomassa , Ácidos Carboxílicos/metabolismo , Fermentação , Glucose/metabolismo , Hidrólise , Ozônio/química , Gases em Plasma/metabolismo , Temperatura , Fatores de Tempo , Ácido Vanílico/metabolismo
7.
Appl Biochem Biotechnol ; 163(4): 558-72, 2011 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-20725803

RESUMO

O3 generated in a plasma at atmospheric pressure and room temperature, fed with dried air (or oxygen-enriched dried air), has been used for the degradation of lignin in wheat straw to optimize the enzymatic hydrolysis and to get more fermentable sugars. A fixed bed reactor was used combined with a CO2 detector and an online technique for O3 measurement in the fed and exhaust gas allowing continuous measurement of the consumption of O3. This rendered it possible for us to determine the progress of the pretreatment in real time (online analysis). The process time can be adjusted to produce wheat straw with desired lignin content because of the online analysis. The O3 consumption of wheat straw and its polymeric components, i.e., cellulose, hemicellulose, and lignin, as well as a mixture of these, dry as well as with 50% water, were studied. Furthermore, the process parameters dry matter content and milled particle size (the extent to which the wheat straw was milled) were investigated and optimized. The developed methodology offered the advantage of a simple and relatively fast (0.5-2 h) pretreatment allowing a dry matter concentration of 45-60%. FTIR measurements did not suggest any structural effects on cellulose and hemicellulose by the O3 treatment. The cost and the energy consumption for lignin degradation of 100 g of wheat straw were calculated.


Assuntos
Gases em Plasma/química , Triticum/química , Triticum/metabolismo , Biocombustíveis , Reatores Biológicos , Celulase/metabolismo , Hidrólise , Cinética , Lignina/metabolismo , Ozônio/química , Ozônio/metabolismo , Tamanho da Partícula , Espectroscopia de Infravermelho com Transformada de Fourier , Trichoderma/enzimologia , Xilanos/metabolismo
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