Detalhe da pesquisa
1.
Characterization of tritiated JNJ-GluN2B-5 (3-[3H] 1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methyl-phenyl)pyrrolo[3,2-b]pyridin-1-yl)ethanone), a high affinity GluN2B radioligand with selectivity over sigma receptors.
J Neurochem
; 2024 May 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38770633
2.
P2X7 receptor antagonists for the treatment of systemic inflammatory disorders.
Prog Med Chem
; 59: 63-99, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32362329
3.
Transient P2X7 Receptor Antagonism Produces Lasting Reductions in Spontaneous Seizures and Gliosis in Experimental Temporal Lobe Epilepsy.
J Neurosci
; 36(22): 5920-32, 2016 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27251615
4.
The evolution of P2X7 antagonists with a focus on CNS indications.
Bioorg Med Chem Lett
; 26(16): 3838-45, 2016 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27426304
5.
Preclinical characterization of substituted 6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one P2X7 receptor antagonists.
Bioorg Med Chem Lett
; 26(2): 257-261, 2016 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26707399
6.
Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia.
J Pharmacol Exp Ther
; 354(3): 471-82, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26177655
7.
Novel methyl substituted 1-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanones are P2X7 antagonists.
Bioorg Med Chem Lett
; 25(16): 3157-63, 2015 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26099534
8.
Pharmacology of a novel central nervous system-penetrant P2X7 antagonist JNJ-42253432.
J Pharmacol Exp Ther
; 351(3): 628-41, 2014 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-25271258
9.
P2X7 antagonists as potential therapeutic agents for the treatment of CNS disorders.
Prog Med Chem
; 53: 65-100, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24418608
10.
Molecular determinants of ASIC1 modulation by divalent cations.
Sci Rep
; 14(1): 2320, 2024 01 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38282035
11.
Discovery of a Series of Substituted 1H-((1,2,3-Triazol-4-yl)methoxy)pyrimidines as Brain Penetrants and Potent GluN2B-Selective Negative Allosteric Modulators.
J Med Chem
; 66(4): 2877-2892, 2023 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36757100
12.
Molecular mechanism and structural basis of small-molecule modulation of the gating of acid-sensing ion channel 1.
Commun Biol
; 4(1): 174, 2021 02 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33564124
13.
Synthesis of a histamine H(3) receptor antagonist-manipulation of hydroxyproline stereochemistry, desymmetrization of homopiperazine, and nonextractive sodium triacetoxyborohydride reaction workup.
J Org Chem
; 75(13): 4463-71, 2010 Jul 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-20536151
14.
Continued exploration of the triazolopyridine scaffold as a platform for p38 MAP kinase inhibition.
Bioorg Med Chem Lett
; 20(2): 469-73, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19969459
15.
Indole- and benzothiophene-based histamine H3 antagonists.
Bioorg Med Chem Lett
; 20(21): 6226-30, 2010 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20843691
16.
Pre-clinical characterization of aryloxypyridine amides as histamine H3 receptor antagonists: identification of candidates for clinical development.
Bioorg Med Chem Lett
; 20(14): 4210-4, 2010 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20561786
17.
Novel substituted pyrrolidines are high affinity histamine H3 receptor antagonists.
Bioorg Med Chem Lett
; 20(9): 2755-60, 2010 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20382018
18.
Design, Synthesis, and Preclinical Evaluation of 3-Methyl-6-(5-thiophenyl)-1,3-dihydro-imidazo[4,5-b]pyridin-2-ones as Selective GluN2B Negative Allosteric Modulators for the Treatment of Mood Disorders.
J Med Chem
; 63(17): 9181-9196, 2020 09 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32787105
19.
Preclinical Evaluation and Nonhuman Primate Receptor Occupancy Study of 18F-JNJ-64413739, a PET Radioligand for P2X7 Receptors.
J Nucl Med
; 60(8): 1154-1159, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30733317
20.
PET Imaging of the P2X7 Ion Channel with a Novel Tracer [18F]JNJ-64413739 in a Rat Model of Neuroinflammation.
Mol Imaging Biol
; 21(5): 871-878, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30632003