Detalhe da pesquisa
1.
Cyclic amide bioisosterism: strategic application to the design and synthesis of HCV NS5B polymerase inhibitors.
Bioorg Med Chem Lett
; 20(15): 4614-9, 2010 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20584604
2.
3-Hydroxyisoquinolines as inhibitors of HCV NS5b RNA-dependent RNA polymerase.
Bioorg Med Chem Lett
; 19(2): 410-4, 2009 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19070486
3.
Non-nucleoside inhibitors of HCV NS5B polymerase. Part 1: Synthetic and computational exploration of the binding modes of benzothiadiazine and 1,4-benzothiazine HCV NS5b polymerase inhibitors.
Bioorg Med Chem Lett
; 19(13): 3637-41, 2009 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19447623
4.
Non-nucleoside inhibitors of HCV polymerase NS5B. Part 4: structure-based design, synthesis, and biological evaluation of benzo[d]isothiazole-1,1-dioxides.
Bioorg Med Chem Lett
; 19(19): 5652-6, 2009 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19709881
5.
Non-nucleoside inhibitors of HCV polymerase NS5B. Part 3: synthesis and optimization studies of benzothiazine-substituted tetramic acids.
Bioorg Med Chem Lett
; 19(19): 5648-51, 2009 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19700319
6.
The design, synthesis, and antiviral activity of monofluoro and difluoro analogues of 4'-azidocytidine against hepatitis C virus replication: the discovery of 4'-azido-2'-deoxy-2'-fluorocytidine and 4'-azido-2'-dideoxy-2',2'-difluorocytidine.
J Med Chem
; 52(9): 2971-8, 2009 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-19341305
7.
Identification of a C-terminal regulatory motif in hepatitis C virus RNA-dependent RNA polymerase: structural and biochemical analysis.
J Virol
; 77(16): 9020-8, 2003 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-12885918
8.
Expression and purification of untagged full-length HCV NS5B RNA-dependent RNA polymerase.
Protein Expr Purif
; 35(2): 304-12, 2004 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-15135407